2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Apoptosis Membrane Transporter/Ion Channel
  3. mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin
  4. CALP1

CALP1 是一种钙调蛋白 (CaM) 激动剂 (Kd 为 88 µM)，与 CaM EF-hand/Ca2+ 结合位点结合。CALP1 通过抑制钙通道 (calcium channel) 的开放来阻止钙的流入和凋亡 (IC50 为 44.78 µM)。CALP1 阻止谷氨酸受体 ( glutamate receptor channels) 通道，并阻止存储操作的非选择性阳离子通道。CALP1 激活 CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性。

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Custom Peptide Synthesis

CALP1 Chemical Structure

CALP1 Chemical Structure

CAS No. : 145224-99-3

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规格 是否有货
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CALP1 的其他形式现货产品:

Customer Review

Other Forms of CALP1:

CALP1 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 mGluR 亚型特异性产品:

查看所有亚型
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity[1][2][3][4].

IC50 & Target

Kd: 88 µM (Calmodulin)[4]
分子量

842.08

Formula

C40H75N9O10
CAS 号
Sequence

Val-Ala-Ile-Thr-Val-Leu-Val-Lys
Sequence Shortening

VAITVLVK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CALP1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CALP1145224-99-3CALP 1CALP-1mGluRPhosphodiesterase (PDE)ApoptosisCalmodulinMetabotropic glutamate receptorsCaMCalcium-modulated proteinEF-handcalciuminfluxglutamateInhibitorinhibitorinhibit

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