1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
    NF-κB
  2. JAK
    STAT
    NF-κB
  3. Curculigoside

Curculigoside 

目录号: HY-N0705
产品使用指南

Curculigoside 是 C. orchioide 中的主要皂苷,具有显着的抗氧化,抗骨质疏松,抗抑郁和神经保护作用。 通过调节 JAK/STAT/NF-κB 信号传导途径,在体内和体外表现出显着的抗关节炎作用。

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Curculigoside Chemical Structure

Curculigoside Chemical Structure

CAS No. : 85643-19-2

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Description

Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway[1].

IC50 & Target

JAK; STAT; NF-κB[1]

In Vitro

Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 µg/ml in MH7A cells[1].
Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group[1].

Cell Viability Assay[1]

Cell Line: MH7A cells
Concentration: 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml
Incubation Time: 72 hours
Result: Had inhibitory effect on MH7A cells.

Western Blot Analysis[1]

Cell Line: MH7A cells
Concentration: 4 μg/ml; 64 μg/ml
Incubation Time: 24 hours
Result: Downregulated JAK1, JAK3 and STAT3 protein expression.
Molecular Weight

466.44

Formula

C₂₂H₂₆O₁₁

CAS No.

85643-19-2

SMILES

O=C(C(C(OC)=CC=C1)=C1OC)OCC(C=C(O)C=C2)=C2O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
C1   V1   C2   V2

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产品名称:
Curculigoside
目录号:
HY-N0705
需求量:

Curculigoside

Cat. No.: HY-N0705