2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial DNA/RNA Synthesis
  4. Erythromycin lactobionate

Erythromycin lactobionate  (Synonyms: 乳糖酸红霉素)

目录号: HY-B0220A
COA 产品使用指南 技术支持

Erythromycin lactobionate 是由放线菌产生的大环内酯类抗生素 (antibiotic)，具有广谱抗菌活性。Erythromycin lactobionate 通过结合细菌的 50S 核糖体亚基而起作用，并通过阻断转肽和/或易位反应来抑制 RNA 依赖性蛋白 (RNA-dependent protein synthesis) 的合成，而不会影响核酸的合成。Erythromycin lactobionate 在不同领域的研究中显示出抗肿瘤特性和保护神经的作用。

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Erythromycin lactobionate

Erythromycin lactobionate Chemical Structure

CAS No. : 3847-29-8

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规格 价格 是否有货 数量
25 mg ￥150
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50 mg ￥210
In-stock
100 mg ￥295
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500 mg   询价  

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Other Forms of Erythromycin lactobionate:

Erythromycin lactobionate 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].

IC50 & Target

Macrolide

 

体外研究
(In Vitro)

Erythromycin lactobionate inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively[1].
Erythromycin lactobionate (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (p<0.01) and 8-OHdG (p<0.01), reduces Iba-1 (p<0.01) and TNF-α (p<0.01) expression significantly[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Erythromycin lactobionate 相关抗体:

Cell Viability Assay[4]

Cell Line: Embryos primary cortical neuron (from the cerebral cortices of 17-day-old Sprague-Dawley rat)
Concentration: 10, 100 μM
Incubation Time: 24, 72 hours
Result: Improved the viability of cultured neuronal cells in vitro after 3 hours oxygen-glucose deprivation (OGD).
体内研究
(In Vivo)

Erythromycin lactobionate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice[3].
Erythromycin lactobionate (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg[3].
Erythromycin lactobionate (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ddY mice (6 week-old) with EAC cells or CDF mice (6 week-old) with P388 cells[3]
Dosage: 0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration: Gastric intubation; 30-120 days
Result: Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortened the MST in tumorbearing mice.
Animal Model: Male Sprague-Dawley rats (8-week-old, 250-300 g)[4]
Dosage: 50 mg/kg
Administration: Subcutaneous single injection
Result: Reduced infarct volume and edema volume, improved neurological deficit.
Clinical Trial
分子量

1092.22

Formula

C49H89NO25
CAS 号
性状

固体

颜色

White to off-white

中文名称

乳糖酸红霉素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 100 mg/mL (91.56 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9156 mL 4.5778 mL 9.1557 mL
5 mM 0.1831 mL 0.9156 mL 1.8311 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Erythromycin lactobionate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9156 mL 4.5778 mL 9.1557 mL 22.8892 mL
5 mM 0.1831 mL 0.9156 mL 1.8311 mL 4.5778 mL
10 mM 0.0916 mL 0.4578 mL 0.9156 mL 2.2889 mL
15 mM 0.0610 mL 0.3052 mL 0.6104 mL 1.5259 mL
20 mM 0.0458 mL 0.2289 mL 0.4578 mL 1.1445 mL
25 mM 0.0366 mL 0.1831 mL 0.3662 mL 0.9156 mL
30 mM 0.0305 mL 0.1526 mL 0.3052 mL 0.7630 mL
40 mM 0.0229 mL 0.1144 mL 0.2289 mL 0.5722 mL
50 mM 0.0183 mL 0.0916 mL 0.1831 mL 0.4578 mL
60 mM 0.0153 mL 0.0763 mL 0.1526 mL 0.3815 mL
80 mM 0.0114 mL 0.0572 mL 0.1144 mL 0.2861 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Erythromycin lactobionate3847-29-8乳糖酸红霉素AntibioticBacterialDNA/RNA SynthesisactinomycetestreptomycesantimicrobialtumorcancerEACP388antitumorneuroprotectiveInhibitorinhibitorinhibit

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