2. Gene
  3. ALK - ALK receptor tyrosine kinase Gene

ALK - ALK receptor tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ALK 受体酪氨酸激酶

种属: Canis lupus familiaris (sub-species: familiaris)

基因 ID: 483021 | 基因类型: protein coding

关于 ALK

Primary_assembly 17: 23,572,834-24,250,519 reverse strand.ROS_Cfam_1.0:CM025116.1

This gene has 1 transcript (splice variant), 195 orthologues and 54 paralogues.

ALK 基因产物(2)

mRNA Protein Name
XM_038691158.1 XP_038547086.1 ALK tyrosine kinase receptor isoform X1
XM_038691158.1 XP_038547086.1 ALK tyrosine kinase receptor isoform X1

ALK 蛋白结构

MAM

MAM: cd06263 (281 - 439)

LDLa

LDLa: smart00192 (456 - 482)

MAM

MAM: cl27660 (495 - 651)

PTKc_ALK_LTK

PTKc_ALK_LTK: cd05036 (1124 - 1400)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1632 a.a.
蛋白主名 其他名称

ALK tyrosine kinase receptor

anaplastic lymphoma kinase (Ki-1)

anaplastic lymphoma receptor tyrosine kinase

相关产品

Approval
生物活性分子 (18)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50878 Crizotinib 99.97% 是
HY-12215 Lorlatinib 99.92% 是
HY-15656 Ceritinib Inhibitor 99.92% 是
HY-12678 Entrectinib 99.79% 是
HY-13011 Alectinib Inhibitor 99.78% 是
HY-12857 Brigatinib Inhibitor 99.98% 是
HY-103022 Repotrectinib Inhibitor 99.93% 否
HY-15656A Ceritinib dihydrochloride Inhibitor 99.90% 是
HY-13011A Alectinib Hydrochloride Inhibitor 99.92% 是
HY-50878A Crizotinib hydrochloride 99.86% 是
HY-103714A Ensartinib dihydrochloride Inhibitor 99.73% 否
HY-145574 Iruplinalkib Inhibitor 99.62% 否
HY-103714 Ensartinib Inhibitor 99.93% 否
HY-100375 Diroximel fumarate Activator 99.90% 是
HY-13464 ALK-IN-1 Inhibitor 99.94% 否
HY-123689 Samidorphan 99.04% 否
HY-12215R Lorlatinib (Standard) 99.92% 否
HY-50878B Crizotinib acetate Inhibitor / 否
Clinical Phase
生物活性分子 (17)
目录号 产品名 作用方式
纯度 Phase
HY-16590 X-376 Inhibitor 98.10% Phase 3
HY-19928 Vactosertib Inhibitor 99.53% Phase 2
HY-103021 LY3200882 Inhibitor 99.87% Phase 2
HY-139279 Zotizalkib Inhibitor 98.02% Phase 2
HY-109084 Conteltinib Inhibitor 99.0% Phase 2
HY-17603 Belizatinib Inhibitor 99.62% Phase 2
HY-109179 Itacnosertib Inhibitor 99.06% Phase 2
HY-145608 Zilurgisertib Inhibitor 98.25% Phase 2
HY-136773A KER047 succinate Inhibitor 98.93% Phase 2
HY-136788 ALK4290 Inhibitor 99.79% Phase 2
HY-136773 KER047 Inhibitor 99.35% Phase 2
HY-15841 CEP-37440 Inhibitor 99.91% Phase 1
HY-117887 Fidrisertib Inhibitor 98.17% Phase 1
HY-155163 APG-2449 Inhibitor 98.93% Phase 1
HY-135366 HPN-01 Inhibitor 98.61% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-142287 Con B-1 Inhibitor / Phase 1
抗体抑制剂 (3)
目录号 产品名 作用方式
纯度 Phase
HY-P99752 Nemvaleukin alfa 99.50% Phase 2
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2
HY-P990022 Prafnosbart Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (227)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10431 SB-431542 Inhibitor 99.85% 否
HY-13418A Dorsomorphin Inhibitor 99.91% 否
HY-10432 A 83-01 Inhibitor 99.33% 否
HY-13418 Dorsomorphin dihydrochloride Inhibitor 99.91% 否
HY-12071 LDN193189 Inhibitor 99.48% 否
HY-13012 RepSox Inhibitor 99.92% 否
HY-12273 DMH-1 Inhibitor 99.95% 否
HY-12043 SB 525334 Inhibitor 99.97% 否
HY-131442 Alkyne-phenol 99.72% 否
HY-12071B LDN-193189 dihydrochloride Inhibitor 99.75% 否
HY-12071A LDN193189 Tetrahydrochloride Inhibitor 99.79% 否
HY-10432A A 83-01 sodium Inhibitor 98.43% 否
HY-13521 SB-505124 Inhibitor 99.73% 否
HY-W040304 Alkynyl Palmitic Acid ≥97.0% 否
HY-16712 LDN-214117 Inhibitor 99.92% 否
HY-13227 SD-208 Inhibitor 99.87% 否
HY-10326 GW788388 Inhibitor 99.92% 否
HY-10192 NVP-TAE 684 99.70% 否
HY-15609 AZD-3463 99.31% 否
HY-15897 LDN-212854 Inhibitor 99.70% 否
HY-112155 MS4078 Inhibitor 99.72% 否
HY-12278 K02288 Inhibitor 99.65% 否
HY-12274 ML347 Inhibitor 99.94% 否
HY-12953 R-268712 Inhibitor 99.92% 否
HY-13020 GSK1838705A Inhibitor 99.58% 否
HY-156467 Neladalkib 99.90% 否
HY-153386 CPD-1224 Inhibitor 99.83% 否
HY-13012G RepSox (GMP) Inhibitor / 否
HY-19928A Vactosertib Hydrochloride Inhibitor 99.22% 是
HY-111482 SM 16 Inhibitor 99.82% 否
HY-18758 IN-1130 Inhibitor 99.93% 否
HY-18766 EW-7195 Inhibitor 98.84% 否
HY-144043 ALK5-IN-8 Inhibitor 98.06% 否
HY-123919 TL13-112 Inhibitor 98.01% 否
HY-19628 OD36 Inhibitor 99.33% 否
HY-10431R SB-431542 (Standard) Inhibitor 99.38% 否
HY-160506 PRO-6E 99.85% 否
HY-150169 THRX-144644 Inhibitor 99.90% 否
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% 否
HY-122856 AZ12601011 Inhibitor 99.78% 否
HY-10432G A 83-01 (GMP) Inhibitor / 否
HY-12678S1 Entrectinib-d8 99.82% 否
HY-148234 M4K2234 Inhibitor 98.31% 否
HY-19990 ALK kinase inhibitor-1 Inhibitor 99.87% 否
HY-18030A CEP-28122 mesylate salt Inhibitor 99.92% 否
HY-123856 MY10 99.87% 否
HY-112815 ALK2-IN-2 Inhibitor 99.93% 否
HY-112156 MS4077 Inhibitor 99.66% 否
HY-147219A SIAIS164018 hydrochloride 98.06% 否
HY-152845 Ficonalkib Inhibitor 98.55% 否
HY-10327 GW-6604 Inhibitor ≥98.0% 否
HY-78349 A 77-01 Inhibitor 99.92% 否
HY-109179A Itacnosertib hydrochloride Inhibitor 99.43% 否
HY-125851 TP-008 Inhibitor 99.42% 否
HY-156467A Neladalkib TFA 99.70% 否
HY-160520 ALK-IN-28 Inhibitor 99.30% 否
HY-50878S Crizotinib-d5 99.60% 否
HY-13521A SB-505124 hydrochloride Inhibitor 99.34% 否
HY-122582 TL13-12 Inhibitor 98.06% 否
HY-12331 KRCA-0008 96.19% 否
HY-13783 BIBF0775 Inhibitor 99.42% 否
HY-15358 ALK inhibitor 2 Inhibitor 99.57% 否
HY-112140 JH-VIII-157-02 Inhibitor 98.98% 否
HY-109084A Conteltinib tetrahydrochloride Inhibitor / 否
HY-151289 ALK5-IN-34 Inhibitor 98.21% 否
HY-15801 HG-14-10-04 Inhibitor 99.09% 否
HY-164397 XMU-MP-5 99.00% 否
HY-E70357 Alkaline Phosphatase (ALP), Human Placental / 否
HY-159147 SIA​​IS039 99.68% 否
HY-12273R DMH-1 (Standard) Inhibitor 99.78% 否
HY-15357 ALK inhibitor 1 Inhibitor 99.62% 否
HY-163807 22-SLF Degrader / 否
HY-172412 Alixorexton Agonist / 否
HY-N4126 6-Demethoxytangeretin Inhibitor 99.37% 否
HY-112801 F-1 Inhibitor 98.03% 否
HY-111752 EML4-ALK kinase inhibitor 1 Inhibitor 98.02% 否
HY-10432R A 83-01 (Standard) Inhibitor 98.69% 否
HY-12678S Entrectinib-d4 Inhibitor / 否
HY-135887 ZX-29 98.59% 否
HY-136194 TL13-22 Inhibitor 99.71% 否
HY-147219 SIAIS164018 / 否
HY-155939 M4K2163 dihydrochloride Inhibitor 98.30% 否
HY-156432 ALK-IN-26 99.87% 否
HY-15656S Ceritinib-d7 Inhibitor 98.00% 否
HY-160237 HYL001 Inhibitor 99.94% 否
HY-168990 Ontunisertib Inhibitor / 否
HY-N4107 Phyllanthin Inhibitor 99.96% 否
HY-123689S Samidorphan-d4 / 否
HY-123689S1 Samidorphan-d5 Antagonist / 否
HY-RS00598 ALK Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-18030 CEP-28122 Inhibitor / 否
HY-128569 ALK-IN-5 Inhibitor / 否
HY-128596 ALK-IN-6 Inhibitor / 否
HY-13011S1 Alectinib-d6 Inhibitor 98.05% 否
HY-132229 LPM4870108 Inhibitor / 否
HY-135509 Lorlatinib acetate / 否
HY-131909 CJ-2360 Inhibitor / 否
HY-108230 ALK-IN-12 Inhibitor / 否
HY-110347 Mps1-IN-1 dihydrochloride Inhibitor / 否
HY-112877 ALK-5-IN-1 Inhibitor / 否
HY-120387 SMU-B Inhibitor / 否
HY-120663 KRCA-0713 Inhibitor / 否
HY-12215S2 Deulorlatinib / 否
HY-12857S Brigatinib-13C6 Inhibitor / 否
HY-12973 ALK-IN-13 Inhibitor / 否
HY-13011S Alectinib-d8 Inhibitor / 否
HY-130794 ALK/ROS1-IN-1 Inhibitor / 否
HY-131244 ALK-IN-9 Inhibitor / 否
HY-136195 TL13-110 Inhibitor / 否
HY-136788A ALK4290 dihydrochloride Inhibitor / 否
HY-137918 TGF-βRI inhibitor 3 Inhibitor 99.16% 否
HY-142949 ALK5-IN-7 Inhibitor / 否
HY-142950 ALK5-IN-6 Inhibitor / 否
HY-143557 Trk-IN-7 Inhibitor / 否
HY-144423 Trk-IN-10 Inhibitor / 否
HY-144437 ALK5-IN-9 Inhibitor / 否
HY-144732 TRK/ALK-IN-1 Inhibitor / 否
HY-145855 J-1063 Inhibitor / 否
HY-146022 SIAIS117 Inhibitor / 否
HY-146408 ALK-IN-21 Inhibitor / 否
HY-146694 RIPK2-IN-1 Inhibitor / 否
HY-146780 TGFβRI-IN-4 Inhibitor / 否
HY-147206 Biotin-PEG-Alk (MW 600) / 否
HY-147206A Biotin-PEG-Alk (MW 1000) / 否
HY-147206B Biotin-PEG-Alk (MW 2000) / 否
HY-147206C Biotin-PEG-Alk (MW 3400) / 否
HY-147206D Biotin-PEG-Alk (MW 5000) / 否
HY-147206E Biotin-PEG-Alk (MW 10000) / 否
HY-147206F Biotin-PEG-Alk (MW 20000) / 否
HY-147833 ALK-IN-22 / 否
HY-148246 MU1700 Inhibitor / 否
HY-149403 J-1048 Inhibitor / 否
HY-151155 ALK-IN-23 Inhibitor / 否
HY-151233 ALK5-IN-10 Inhibitor / 否
HY-151270 ALK5-IN-25 Inhibitor / 否
HY-151272 ALK5-IN-26 Inhibitor / 否
HY-151273 ALK5-IN-27 Inhibitor / 否
HY-151275 ALK5-IN-28 Inhibitor / 否
HY-151277 ALK5-IN-29 Inhibitor / 否
HY-151279 ALK5-IN-30 Inhibitor / 否
HY-151281 ALK5-IN-31 Inhibitor / 否
HY-151282 ALK5-IN-32 Inhibitor / 否
HY-151283 ALK5-IN-33 Inhibitor / 否
HY-153246 ALK2-IN-5 Inhibitor / 否
HY-155227 ALK/EGFR-IN-1 / 否
HY-155227A ALK/EGFR-IN-2 Inhibitor / 否
HY-155227B ALK/EGFR-IN-3 Inhibitor / 否
HY-155227S ALK/EGFR-IN-1-d5 / 否
HY-156470 Multi-kinase-IN-6 / 否
HY-157391 ALK/ROS1-IN-3 Inhibitor / 否
HY-159952 ALK5-IN-84 Inhibitor / 否
HY-161350 ALK/HDAC-IN-1 Inhibitor / 否
HY-161376 M4K2281 Inhibitor / 否
HY-161377 M4K2306 Inhibitor / 否
HY-161662 ALK5-IN-80 Inhibitor / 否
HY-161749 PROTAC ALK degrader-1 Degrader / 否
HY-161750 PROTAC ALK degrader-2 Degrader / 否
HY-161910 SH-E4A-66 Inhibitor / 否
HY-163429 J-1149 Inhibitor / 否
HY-163507 ALK5-IN-79 Inhibitor / 否
HY-167388 PLLA5000-PEG5000-ALK / 否
HY-167389 PLLA5000-PEG3000-ALK / 否
HY-167390 PLLA5000-PEG2000-ALK / 否
HY-167391 PLLA5000-PEG1000-ALK / 否
HY-167392 PLLA4000-PEG5000-ALK / 否
HY-167393 PLLA4000-PEG3000-ALK / 否
HY-167394 PLLA4000-PEG2000-ALK / 否
HY-167395 PLLA4000-PEG1000-ALK / 否
HY-167396 PLLA3000-PEG5000-ALK / 否
HY-167397 PLLA3000-PEG3000-ALK / 否
HY-167398 PLLA3000-PEG2000-ALK / 否
HY-167399 PLLA3000-PEG1000-ALK / 否
HY-167400 PLLA2000-PEG5000-ALK / 否
HY-167401 PLLA2000-PEG3000-ALK / 否
HY-167402 PLLA2000-PEG2000-ALK / 否
HY-167403 PLLA2000-PEG1000-ALK / 否
HY-167404 PLLA1000-PEG5000-ALK / 否
HY-167405 PLLA1000-PEG3000-ALK / 否
HY-167406 PLLA1000-PEG2000-ALK / 否
HY-167407 PLLA1000-PEG1000-ALK / 否
HY-167408 PLLA10000-PEG5000-ALK / 否
HY-167409 PLLA10000-PEG3000-ALK / 否
HY-167410 PLLA10000-PEG2000-ALK / 否
HY-167864 M4K2308 Inhibitor / 否
HY-168513 ALK-IN-29 Inhibitor / 否
HY-168551 PROTAC ALK degrader-3 Degrader / 否
HY-168552 3-Hydroxyazetidine-Cyclohexanol / 否
HY-168553 3-Hydroxyazetidine-Cyclohexanol-5-Aminothalidomide / 否
HY-168607 ALK5-IN-83 Inhibitor / 否
HY-169482 ALK protein ligand-1 Inhibitor / 否
HY-170418 ALK/ROS1-IN-5 / 否
HY-170592 dALK-3 Degrader / 否
HY-170928 DA-0157 Inhibitor / 否
HY-172240 Tosposertib Inhibitor / 否
HY-172426 Dirozalkib Inhibitor / 否
HY-172958 F6524-1593 Inhibitor / 否
HY-173007 ALK/PI3K/AKT-IN-1 / 否
HY-173149 CDD-2789 Inhibitor / 否
HY-173493 ALK-IN-31 / 否
HY-174314 WZH-15-125 Inhibitor / 否
HY-174315 WZH-17-002 / 否
HY-174368 PROTAC EML4-ALK Degrader-1 / 否
HY-175271 JWJ-01-378 / 否
HY-175527 ALK degrader 2 / 否
HY-175528 ALK ligand-Linker Conjugate 1 / 否
HY-176347S Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-19628A OD36 hydrochloride Inhibitor / 否
HY-50878AS Crizotinib-d9 hydrochloride / 否
HY-N0679S Retinyl acetate-d3 / 否
HY-RS00599 Alk Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS00600 ALK Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W707119 RepSox hydrochloride Inhibitor / 否
HY-W754809 ALK ligand-1 Ligand / 否
HY-118528 TP0427736 Inhibitor / 否
HY-12857S2 Brigatinib-d11 Inhibitor / 否
HY-14243 CEP-14083 Inhibitor / 否
HY-158905 MTDB-Alkyne Degrader / 否
HY-160172 ALK/ROS1-IN-4 Inhibitor / 否
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / 否
HY-162902 ALK5-IN-82 Inhibitor / 否
HY-168163 CDK12/13 ligand 1 Degrader / 否
HY-169481 AP-1 Degrader / 否
HY-18030B CEP-28122 mesylate hydrochloride Inhibitor / 否
HY-50878S1 Crizotinib-d8 / 否
HY-50878S2 Crizotinib-d9 / 否
HY-W814315 Alectinib analog / 否
HY-111416 WY-135 Inhibitor / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991474 TATX-21 Inhibitor / 否
HY-P991533 DLX-521 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ALK NCBI NCBI:238
Macaca fascicularis ALK NCBI NCBI:102128455
Mus musculus ALK NCBI NCBI:11682
Rattus norvegicus ALK NCBI NCBI:266802
Macaca mulatta ALK NCBI NCBI:704823
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