1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. Histone Acetyltransferase
    STAT
  3. L002

L002 

目录号: HY-100671
产品使用指南

L002 是一种新型强效特异性乙酰转移酶 p300 (KAT3B) 抑制剂,IC50 为 1.98 uM。L002 对 PCAF 和 GCN5 具有弱抑制作用 (IC50 分别为 35 和 34 μM)。L002 阻断组蛋白乙酰化和 p53 乙酰化,并抑制 STAT3 活化。

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L002 Chemical Structure

L002 Chemical Structure

CAS No. : 321695-57-2

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Description

L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases[1]. L002 blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation[2].

IC50 & Target

IC50: 1.98 uM (KAT3B); 35 µM (PCAF); 34 µM (GCN5)[1] ;STAT3; p53[2]

Molecular Weight

321.35

Formula

C₁₅H₁₅NO₅S

CAS No.

321695-57-2

SMILES

O=C1C(C)=C/C(C=C1C)=N\OS(=O)(C2=CC=C(OC)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
L002
目录号:
HY-100671
需求量:

L002

Cat. No.: HY-100671