2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Telenzepine dihydrochloride

Telenzepine dihydrochloride  (Synonyms: 替仑西平二盐酸盐)

目录号: HY-B1789A 纯度: 99.08%
COA 产品使用指南

摩尔计算器

Telenzepine dihydrochloride 是一种选择性和具有口服活性的毒蕈碱 M1 受体拮抗剂，Ki 为 0.94 nM。Telenzepine dihydrochloride 抑制胃酸分泌并具有抗溃疡作用。

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Telenzepine dihydrochloride Chemical Structure

Telenzepine dihydrochloride Chemical Structure

CAS No. : 147416-96-4

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Customer Review

Other Forms of Telenzepine dihydrochloride:

Telenzepine dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telenzepine dihydrochloride is a selective and orally active muscarinic M1 receptor antagonist with a Ki of 0.94 nM. Telenzepine dihydrochloride inhibits gastric acid secretion and has antiulcer effects[1][2][3].

IC50 & Target

mAChR1

 

体外研究
(In Vitro)

At submicromolar concentrations (100 nM), Telenzepine abolishes responses to either muscarine or the muscarinic component of the acetylcholine response. The excitatory effect of muscarine at postsynaptic M1 receptors is dose dependently inhibited by Telenzepine (0.1-1000 nM) at concentrations[2].
The threshold dose of Telenzepine as an antagonist of the muscarinic depolarization in AH/type 2 neurons is in the range of 0.1-1 nM. The IC50 of Telenzepine needed to abolish the response is 8.5 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telenzepine dihydrochloride 相关抗体:
体内研究
(In Vivo)

Intravenous Telenzepine potently inhibits gastric acid secretion in the Ghosh-Schild rat (carbachol-stimulated), the chronic fistula rat (basal secretion), or, both intravenously and orally, in the modified Shay rat[1].
Telenzepine (2.7 μmol/kg; orally) treatment shows significantly longer duration antiulcer effects in the modified Shay rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

443.39

Formula

C19H24Cl2N4O2S
CAS 号
性状

固体

颜色

White to off-white

中文名称

替仑西平 二盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 62.5 mg/mL (140.96 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2554 mL 11.2768 mL 22.5535 mL
5 mM 0.4511 mL 2.2554 mL 4.5107 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Telenzepine dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2554 mL 11.2768 mL 22.5535 mL 56.3838 mL
5 mM 0.4511 mL 2.2554 mL 4.5107 mL 11.2768 mL
10 mM 0.2255 mL 1.1277 mL 2.2554 mL 5.6384 mL
15 mM 0.1504 mL 0.7518 mL 1.5036 mL 3.7589 mL
20 mM 0.1128 mL 0.5638 mL 1.1277 mL 2.8192 mL
25 mM 0.0902 mL 0.4511 mL 0.9021 mL 2.2554 mL
30 mM 0.0752 mL 0.3759 mL 0.7518 mL 1.8795 mL
40 mM 0.0564 mL 0.2819 mL 0.5638 mL 1.4096 mL
50 mM 0.0451 mL 0.2255 mL 0.4511 mL 1.1277 mL
60 mM 0.0376 mL 0.1879 mL 0.3759 mL 0.9397 mL
80 mM 0.0282 mL 0.1410 mL 0.2819 mL 0.7048 mL
100 mM 0.0226 mL 0.1128 mL 0.2255 mL 0.5638 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telenzepine147416-96-4替仑西平 二盐酸盐mAChRMuscarinic acetylcholine receptorM1-receptorantimuscarinicantisecretoryantiulcergastricacidexcitatoryInhibitorinhibitorinhibit

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