2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. ADT-007

ADT-007 是一种有效的口服活性泛 RAS 抑制剂，具有很强的抗癌作用。ADT-007 以无核苷酸构象结合 RAS，阻断 GTP 激活。ADT-007 可有效、选择性地抑制野生型 RAS 同工酶突变或过度激活的癌细胞的生长。

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ADT-007 Chemical Structure

ADT-007 Chemical Structure

CAS No. : 1945941-09-2

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规格 价格 是否有货
5 mg ￥2700
询问价格 & 货期
10 mg ￥4350
询问价格 & 货期
25 mg ￥8700
询问价格 & 货期

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Customer Review

ADT-007 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADT-007 is a potent and orally active pan-RAS inhibitor with strong anticancer effects. ADT-007 binds RAS in a nucleotide-free conformation to block GTP activation. ADT-007 potently and selectively inhibits the growth of cancer cells with mutated or hyper-activated wild-type RAS isozymes[1].

体外研究
(In Vitro)

ADT-007 显示出抑制 KRASG13D HCT-116 细胞生长的最高效力和选择性，IC50 为 5 nM，而 RAS 110 野生型 HT-29 细胞的敏感性要低约 100 倍，IC50 为 493 nM。ADT-007 在 KRAS G12C MIA PaCa-2 PDA 细胞中显示出更强的效力，导致 IC50 值低至 2 nM。ADT-007 还可有效抑制其他三种具有 G12V 或 G12D 突变的 KRAS PDA 突变细胞系的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ADT-007 相关抗体:
体内研究
(In Vivo)

ADT-007（10 mg/kg；肿瘤内注射；每天一次；持续 17-21 天）强烈抑制同基因免疫活性小鼠结直肠癌模型中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8-week-old BALB/C mice injected with colorectal cancer cells[1]
Dosage: 10 mg/kg
Administration: intra-tumoral injection; once a day; for 17-21 days
Result: Strongly inhibited tumor growth.
分子量

449.47

Formula

C26H24FNO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ADT-007 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADT-0071945941-09-2ADT007ADT 007Raspan-RAS inhibitorGTP activationInhibitorinhibitorinhibit

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产品名称：
ADT-007
目录号：
HY-157887
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