1. PI3K/Akt/mTOR Stem Cell/Wnt
  2. GSK-3
  3. BIP-135

BIP-135 是一个高效、选择性的,ATP 竞争性的 GSK-3 抑制剂,对 GSK-3αGSK-3β 作用的IC50 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。

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BIP-135 Chemical Structure

BIP-135 Chemical Structure

CAS No. : 941575-71-9

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10 mM * 1 mL in DMSO ¥1650
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查看 GSK-3 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].

IC50 & Target

GSK-3α

16 nM (IC50)

GSK-3β

21 nM (IC50)

体外研究
(In Vitro)

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1].
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human SMA fibroblasts
Concentration: 20 μM, 25 μM, 30 μM
Incubation Time: 72 hours
Result: Led to a 7-fold increase in SMN levels at 25 μM.
体内研究
(In Vivo)

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female SMN2+/+, SMN2Δ7+/+, Smn+/– mice[1]
Dosage: 75 mg/kg
Administration: Intraperitoneal injection; daily; from postnatal day 0 to 21
Result: Caused a modest extension in the median survival of SMA KO animals by two days.
分子量

421.24

Formula

C21H13BrN2O3

CAS 号
性状

固体

颜色

Light yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 62.5 mg/mL (148.37 mM; 超声助溶 (<70°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3739 mL 11.8697 mL 23.7394 mL
5 mM 0.4748 mL 2.3739 mL 4.7479 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.86%

参考文献

BIP-135 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3739 mL 11.8697 mL 23.7394 mL 59.3486 mL
5 mM 0.4748 mL 2.3739 mL 4.7479 mL 11.8697 mL
10 mM 0.2374 mL 1.1870 mL 2.3739 mL 5.9349 mL
15 mM 0.1583 mL 0.7913 mL 1.5826 mL 3.9566 mL
20 mM 0.1187 mL 0.5935 mL 1.1870 mL 2.9674 mL
25 mM 0.0950 mL 0.4748 mL 0.9496 mL 2.3739 mL
30 mM 0.0791 mL 0.3957 mL 0.7913 mL 1.9783 mL
40 mM 0.0593 mL 0.2967 mL 0.5935 mL 1.4837 mL
50 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1870 mL
60 mM 0.0396 mL 0.1978 mL 0.3957 mL 0.9891 mL
80 mM 0.0297 mL 0.1484 mL 0.2967 mL 0.7419 mL
100 mM 0.0237 mL 0.1187 mL 0.2374 mL 0.5935 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BIP-135
目录号:
HY-111055
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