2. Anti-infection NF-κB MAPK/ERK Pathway Apoptosis Immunology/Inflammation
  3. Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related
  4. Ceftiofur hydrochloride

Ceftiofur hydrochloride  (Synonyms: 头孢噻呋盐酸盐)

目录号: HY-B0026 纯度: 98.43%
COA 产品使用指南 技术支持

Ceftiofur hydrochloride 是一种靶向细菌青霉素结合蛋白 (PBPs) 的细胞壁合成抑制剂，在内毒素血症中具有抗炎作用。Ceftiofur hydrochloride 通过抑制细菌细胞壁肽聚糖的合成发挥杀菌作用，导致细菌细胞裂解。Ceftiofur hydrochloride 还抑制 NF-κB 和 MAPKs 的激活，从而减少 TNF-α、IL-1β 和 IL-6 等促炎细胞因子的分泌。

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Ceftiofur hydrochloride

Ceftiofur hydrochloride Chemical Structure

CAS No. : 103980-44-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥242
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100 mg ￥220
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500 mg   询价  

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Customer Review

Other Forms of Ceftiofur hydrochloride:

Ceftiofur hydrochloride 相关抗体

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ceftiofur hydrochloride is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur hydrochloride exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur hydrochloride also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3].

IC50 & Target

bacterial[1]
体外研究
(In Vitro)

Ceftiofur (1、5、10 mg/L；预处理 1 h+LPS 刺激 12 h) hydrochloride 可显著抑制 RAW 264.7 细胞 TNF-α、IL-1β、IL-6 分泌，但对 IL-10 分泌无显著影响[2]。
Ceftiofur hydrochloride (1、5、10 mg/L；预处理 1 h+LPS 刺激 30 min) 可显著抑制 RAW 264.7 细胞 ERK、JNK、p38 的磷酸化及 NF-κB p65 的核转位[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ceftiofur hydrochloride 相关抗体:

Western Blot Analysis[2]

Cell Line: RAW 264.7 cells
Concentration: 1, 5, 10 mg/L
Incubation Time: 1 h pretreatment with Ceftiofur followed by 30 min LPS stimulation
Result: Dramatically decreased the phosphorylation levels of ERK, JNK, and p38 in Ceftiofur-treated cells compared to the LPS-treated control cells, while the total protein levels of MAPKs showed no change.

Immunofluorescence[2]

Cell Line: RAW 264.7 cells
Concentration: 1, 5, 10 mg/L
Incubation Time: 1 h pretreatment with Ceftiofur followed by 30 min LPS stimulation
Result: Nuclear translocation of NF-κB p65 induced by LPS was strongly inhibited in a dose-dependent manner in Ceftiofur-pretreated cells.
体内研究
(In Vivo)

Ceftiofur (20 mg/kg；皮下注射；单次；30 mg/kg LPS 挑战前 1 h 或后 0/1 h) hydrochloride 在雌性 C57BL/6 小鼠的内毒素血症模型中可显著提高小鼠存活率，并降低血浆 TNF-α、IL-1β、IL-6 水平，升高 IL-10 水平[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (18-20 g, 6-8 weeks old), LPS-induced endotoxemia model[3]
Dosage: 20 mg/kg Ceftiofur (dissolved in saline)
Administration: Subcutaneous injection, single dose, administered 1 h before or 0, 1, 4, 12 h after intraperitoneal injection of 30 mg/kg LPS.
Result: Pretreatment with 20 mg/kg Ceftiofur 1 h before LPS challenge significantly increased the survival rate of mice (70% survival at 144 h vs. 0% in LPS control group).
When administered 0 or 1 h after LPS injection, Ceftiofur still provided significant protection, but protection decreased when delayed to 4 h and was absent at 12 h.
Plasma levels of TNF-α, IL-1β, and IL-6 in Ceftiofur-pretreated mice were significantly lower than those in the LPS control group at specific time points (1 h for TNF-α, 3 h for IL-6, 12 h for IL-1β), while IL-10 levels were significantly higher at 1 h after LPS challenge.
分子量

560.02

Formula

C19H18ClN5O7S3
CAS 号
性状

固体

颜色

White to light yellow

中文名称

头孢噻呋盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 175 mg/mL (312.49 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7857 mL 8.9283 mL 17.8565 mL
5 mM 0.3571 mL 1.7857 mL 3.5713 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ceftiofur hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7857 mL 8.9283 mL 17.8565 mL 44.6413 mL
5 mM 0.3571 mL 1.7857 mL 3.5713 mL 8.9283 mL
10 mM 0.1786 mL 0.8928 mL 1.7857 mL 4.4641 mL
15 mM 0.1190 mL 0.5952 mL 1.1904 mL 2.9761 mL
20 mM 0.0893 mL 0.4464 mL 0.8928 mL 2.2321 mL
25 mM 0.0714 mL 0.3571 mL 0.7143 mL 1.7857 mL
30 mM 0.0595 mL 0.2976 mL 0.5952 mL 1.4880 mL
40 mM 0.0446 mL 0.2232 mL 0.4464 mL 1.1160 mL
50 mM 0.0357 mL 0.1786 mL 0.3571 mL 0.8928 mL
60 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7440 mL
80 mM 0.0223 mL 0.1116 mL 0.2232 mL 0.5580 mL
100 mM 0.0179 mL 0.0893 mL 0.1786 mL 0.4464 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceftiofur103980-44-5头孢噻呋盐酸盐AntibioticBacterialNF-κBp38 MAPKTNF ReceptorInterleukin RelatedNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRILInhibitorinhibitorinhibit

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