2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Diltiazem hydrochloride

Diltiazem hydrochloride  (Synonyms: 盐酸地尔硫卓; CRD-401)

目录号: HY-14656 纯度: 99.04%
COA 产品使用指南

摩尔计算器

Diltiazem hydrochloride是钙离子流入抑制剂（缓慢通道阻断剂或钙拮抗剂）。

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Diltiazem hydrochloride Chemical Structure

Diltiazem hydrochloride Chemical Structure

CAS No. : 33286-22-5

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥500
In-stock
500 mg ￥400
In-stock
1 g ￥600
In-stock
5 g ￥960
In-stock
10 g   询价  
50 g   询价  

* Please select Quantity before adding items.

Other Forms of Diltiazem hydrochloride:

Diltiazem hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).

IC50 & Target

L-type calcium channel

 

体外研究
(In Vitro)

Benzothiazepine Ca2+ antagonist diltiazem hydrochloride interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels[1]. Diltiazem causes a dose-dependent inhibiton of contractions as well as Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization. Diltiazem is roughly equally potent in inhibiting contractions induced by high-K+ and a low concentration of norepinephrine (NE)[2]. Diltiazem also inhibits the Na-dependent Ca-efflux from heart mitochondria. Both the (+)-optical isomers of the cis- and trans-forms of diltiazem inhibit Na-Ca exchange activity with comparable potency (IC50 of 10-20 μM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diltiazem hydrochloride 相关抗体:
体内研究
(In Vivo)

Diltiazem produces a noncompetitive inhibition of Ca2+-induced contractions of depolarized rabbit aorta. Furthermore, there is a lack of parallelism between the smooth muscle effects of removal of [Ca2+]ex and of addition of diltiazem[2]. Diltiazem improves the cardiac microcirculation and function in an experimental model of hyperthyroidism in rats. The treatment of hyperthyroid rats with losartan diltiazem (4.7±0.7%; P < 0.001) significantly reduces the percentage of fibrosis areas in the left ventricle [4]. In conscious spontaneously hypertensive rats (SHR), diltiazem dose-dependently decreases the blood pressure and increases the heart rate after intravenous administration (0.03--1 mg/kg). Oral administration of diltiazem (100 mg/kg) also reduces the blood pressure of SHR[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

450.98

Formula

C22H27ClN2O4S
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸地尔硫卓； 盐酸地尔硫䓬
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 33.33 mg/mL (73.91 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2174 mL 11.0870 mL 22.1739 mL
5 mM 0.4435 mL 2.2174 mL 4.4348 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (221.74 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Diltiazem hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2174 mL 11.0870 mL 22.1739 mL 55.4348 mL
5 mM 0.4435 mL 2.2174 mL 4.4348 mL 11.0870 mL
10 mM 0.2217 mL 1.1087 mL 2.2174 mL 5.5435 mL
15 mM 0.1478 mL 0.7391 mL 1.4783 mL 3.6957 mL
20 mM 0.1109 mL 0.5543 mL 1.1087 mL 2.7717 mL
25 mM 0.0887 mL 0.4435 mL 0.8870 mL 2.2174 mL
30 mM 0.0739 mL 0.3696 mL 0.7391 mL 1.8478 mL
40 mM 0.0554 mL 0.2772 mL 0.5543 mL 1.3859 mL
50 mM 0.0443 mL 0.2217 mL 0.4435 mL 1.1087 mL
60 mM 0.0370 mL 0.1848 mL 0.3696 mL 0.9239 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diltiazem33286-22-5CRD-401盐酸地尔硫卓 盐酸地尔硫䓬CRD401CRD 401Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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