1. Protein Tyrosine Kinase/RTK
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    PPAR
  3. MSDC-0602K

MSDC-0602K (Synonyms: Azemiglitazone potassium)

目录号: HY-108022A
产品使用指南

MSDC-0602K (Azemiglitazone potassium) 是一种噻唑烷二酮类化合物,与 PPARγ 结合,IC50 为 18.25 μM。MSDC-0602K 调节线粒体丙酮酸载体 (MPC)。MSDC-0602K 可用于脂肪肝的研究,包括功能失调的脂质代谢、炎症和胰岛素抵抗。MSDC-0602K 是一种胰岛素 (insulin) 增敏剂,单独或与 Liraglutide 联合使用可改善小鼠的胰岛素血症和脂肪肝疾病。

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MSDC-0602K Chemical Structure

MSDC-0602K Chemical Structure

CAS No. : 1314533-27-1

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50 mg ¥5200
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  • 参考文献

生物活性

MSDC-0602K (Azemiglitazone potassium), a PPARγ-sparing thiazolidinedione (Ps-TZD), binds to PPARγ with the IC50 of 18.25 μM[1]. MSDC-0602K modulates the mitochondrial pyruvate carrier (MPC). MSDC-0602K can be used for the research of fatty liver including dysfunctional lipid metabolism, inflammation, and insulin resistance[2]. MSDC-0602K, an insulin sensitizer, improves insulinemia and fatty liver disease in mice, alone and in combination with Liraglutide[3].

IC50 & Target[1]

PPAR-γ

18.25 μM (IC50)

体内研究
(In Vivo)

Diabetic db/db and MS-NASH mice are treated with MSDC-0602K by oral gavage, Liraglutide by s.c. injection, or combination MSDC-0602K + Liraglutide. This combination treatment may be an effective therapeutic strategy for diabetes and non-alcoholic steatohepatitis (NASH).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old male db/db mice on C57BL/6J background and age/sex-matched db/+ control mice[1]
Dosage: 30 mg/kg MSDC-0602K; 0.2 mg/kg Liraglutide (obtained from MedChemExpress; HY-P0014)
Administration: MSDC-0602K gavage daily, Liraglutide s.c. injection every other day, or combined MSDC-0602K+ Liraglutide
Result: MSDC-0602K corrected glycemia and reduced insulinemia when given alone, or in combination with Liraglutide. However, MSDC-0602K + Liraglutide combination more significantly improved glucose tolerance and liver histology.
分子量

409.50

Formula

C19H16KNO5S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
MSDC-0602K
目录号:
HY-108022A
需求量: