1. PI3K/Akt/mTOR
  2. mTOR
  3. mTOR inhibitor-7

mTOR inhibitor-7 

目录号: HY-136660
产品使用指南

mTOR inhibitor-7 是一种有口服活性的,可渗透大脑的 mTOR 抑制剂,其 IC50 为 5 nM。详细信息请参考专利文献 WO2017198346A1 中的化合物 44。mTOR inhibitor-7 可用于神经疾病的研究。

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mTOR inhibitor-7 Chemical Structure

mTOR inhibitor-7 Chemical Structure

CAS No. : 1927857-98-4

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Description

mTOR inhibitor-7 is an orally available, and brain-penetrant mTOR inhibitor extracted from patent WO2017198346A1, compound example 44, has an IC50 of 5 nM for mTOR. mTOR inhibitor-7 can be used for the research of neurological disorder[1].

IC50 & Target

IC50: 5 nM (mTOR)[1]

In Vitro

mTOR inhibitor-7 (0.04-5 μΜ; 1 hour) has IC50s of 197 nM and 87 nM for pPKB S473 and pS6 S235/S236, respectively, in-cell western blot. S6 kinase (S6K), S6 ribosomal protein (S6rP) and 4E-binding protein (4E-BP) are prominent downstream effectors of mTOR[1].

Western Blot Analysis[1]

Cell Line: A2058 cells
Concentration: 0.04 μΜ, 0.08 μΜ, 0.155 μΜ, 0.3125 μΜ, 0.625 μΜ, 1.25 μΜ, 5 μΜ
Incubation Time: 1 hour
Result: Inhibited mTOR in cell.
Molecular Weight

435.47

Formula

C₂₀H₂₇F₂N₇O₂

CAS No.

1927857-98-4

SMILES

NC1=NC=C(C2=NC(N3[C@H](C)COC[C@@H]3C)=NC(N4[C@H](C)COCC4)=N2)C(C(F)F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

mTOR inhibitor-7mTOR inhibitor7mTOR inhibitor 7mTORMammalian target of Rapamycinneurologicaldisorderbrain-penetrantInhibitorinhibitorinhibit

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产品名称:
mTOR inhibitor-7
目录号:
HY-136660
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