1. Membrane Transporter/Ion Channel Neuronal Signaling MAPK/ERK Pathway Stem Cell/Wnt GPCR/G Protein NF-κB
  2. Calcium Channel ERK Potassium Channel Guanylate Cyclase NF-κB
  3. N-Salicyloyltryptamine

N-Salicyloyltryptamine 

目录号: HY-147377 纯度: 96.37%
COA 产品使用指南

N-Salicyloyltryptamine 是一种电压依赖性离子通道抑制剂,包括 Na+、Ca2+、K+ 通道。N-Salicyloyltryptamine 抑制 K+ 电流的 IC50 为 34.6 μM (Ito)。N-Salicyloyltryptamine 还具有抗惊厥、抗炎、镇痛,和血管舒张的作用。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

N-Salicyloyltryptamine Chemical Structure

N-Salicyloyltryptamine Chemical Structure

CAS No. : 31384-98-2

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Salicyloyltryptamine acts on voltage-dependent Na+, Ca2+, and K+ ion channels inhibitor. N-Salicyloyltryptamine inhibits K+ currents with an IC50 value of 34.6 μM (Ito). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect[1]-[5].

IC50 & Target

L-type calcium channel

 

potassium channel

34.6 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: E1
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 31057737]
BV-2 IC50
> 100 μM
Compound: 23
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 32182488]
BV-2 IC50
26.4 μM
Compound: 23
Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
[PMID: 32182488]
BV-2 IC50
26.84 μM
Compound: Cpd H
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 34923430]
C6 IC50
> 100 μM
Compound: 23
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 32182488]
C6 IC50
> 40 μM
Compound: 23
Inhibition of LPS-induced NO production in rat C6 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in rat C6 cells incubated for 24 hrs by Griess reagent based assay
[PMID: 32182488]
HeLa IC50
> 100 μM
Compound: E1
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 31057737]
HepG2 IC50
> 100 μM
Compound: E1
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 31057737]
HepG2 EC50
0.21 μM
Compound: CD6
Induction of ABCA1 transcriptional activity in ABCA1p-LUC human HepG2 cells assessed as luciferase activity after 18 hrs
Induction of ABCA1 transcriptional activity in ABCA1p-LUC human HepG2 cells assessed as luciferase activity after 18 hrs
[PMID: 25147608]
HT-22 IC50
101.48 μM
Compound: Cpd H
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 34923430]
MCF7 IC50
> 100 μM
Compound: E1
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 31057737]
MGC-803 IC50
> 100 μM
Compound: E1
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
[PMID: 31057737]
体外研究
(In Vitro)

N-Salicyloyltryptamine (1 ng/mL-1 μg/mL; 24 h) presents no cytotoxicity and causes no oxidative stress in RAW 264.7 cells at low concentration, but (50 and 100 μg/mL) inhibits cell viability with an IC50 value of 22.75 μg/mL[1].
N-Salicyloyltryptamine (1 μg/mL; 24 h) reverses some redox and inflammatory parameters induced by LPS without interfering in cell viability[1].
N-Salicyloyltryptamine (1 μg/mL; 24 h) inhibits LPS-induced TNF-α and IL-1β release, as well as CD40 and TNF-α protein up-regulation[1].
N-Salicyloyltryptamine (1 μg/mL; 24 h) inhibits phosphorylation of ERK 1/2 and IκBα and p65 nuclear translocation (NF-kB activation)[1].
N-Salicyloyltryptamine (17 μM) inhibits K+ current by 59.27% (Ito) and 73.18% (IKD), inhibits L-type Ca2+ currents by 54.9%, and shows few inhibition with high concentration (170 μM) on TTX-sensitive Na+ current by 22.1% in GH3 cells[2].
N-Salicyloyltryptamine (0.01 nM-100 µM) produces vasorelaxation through activation of the NO/sGC/cGMP pathway and reduction of calcium influx[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: RAW 264.7 cell
Concentration: 0.001, 0.05, 1, 50, 100 μg/mL
Incubation Time: 24 hours
Result: Resulted no effect on RAW 264.7 cell viability at 1 μg/mL; however, concentrations of 50 and 100 μg/mL significantly decreased both MTT reduction and SRB incorporation.

RT-PCR[1]

Cell Line: RAW 264.7 cell
Concentration: 1 μg/mL
Incubation Time: 24 hours
Result: Reduced CD40, TNF-α, and RAGE immunocontent.
Inhibited ERK1/2 and IκBα phosphorylation and nuclear translocation of p65.
体内研究
(In Vivo)

N-Salicyloyltryptamine (100 mg/kg; i.p.; 60 min before stimulation challenge) significantly inhibits pentylenetetrazol (PTZ)-induced seizures and partially eliminates the extensor reflex of maximal electric-induced seizures test[4].
N-Salicyloyltryptamine (100 mg/kg, 200 mg/kg; i.p.; single dose) shows antinociceptive and nerve excitability effects[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice (25-35 g)[4]
Dosage: 50, 100, 200 mg/kg
Administration: Intraperitoneal injection; single dose; 60 min before stimulation challenge
Result: Reduced the incidence of clonic pentylenetetrazol (PTZ) seizures and mortality at 50 mg/kg, and decreased the incidence of tonic hindlimb extension (THE) produced by MES at 100, 200 mg/kg.
Animal Model: Male Swiss mice (25-35 g)[5]
Dosage: 100 mg/kg; 200 mg/kg
Administration: Intraperitoneal injection; single dose
Result: Reduced the acetic acid-induced licking response of the injected paw.
分子量

280.32

Formula

C17H16N2O2

CAS 号
性状

固体

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 125 mg/mL (445.92 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5674 mL 17.8368 mL 35.6735 mL
5 mM 0.7135 mL 3.5674 mL 7.1347 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5674 mL 17.8368 mL 35.6735 mL 89.1838 mL
5 mM 0.7135 mL 3.5674 mL 7.1347 mL 17.8368 mL
10 mM 0.3567 mL 1.7837 mL 3.5674 mL 8.9184 mL
15 mM 0.2378 mL 1.1891 mL 2.3782 mL 5.9456 mL
20 mM 0.1784 mL 0.8918 mL 1.7837 mL 4.4592 mL
25 mM 0.1427 mL 0.7135 mL 1.4269 mL 3.5674 mL
30 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
40 mM 0.0892 mL 0.4459 mL 0.8918 mL 2.2296 mL
50 mM 0.0713 mL 0.3567 mL 0.7135 mL 1.7837 mL
60 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
80 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
100 mM 0.0357 mL 0.1784 mL 0.3567 mL 0.8918 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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N-Salicyloyltryptamine
目录号:
HY-147377
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