1. GPCR/G Protein MAPK/ERK Pathway Apoptosis
  2. Ras Apoptosis
  3. ZINC69391

ZINC69391 是一种特异的 Rac1 抑制剂,通过在 Rac1 表面掩蔽 Trp56 残基来干扰 Rac1-GEF 的相互作用。ZINC69391 干扰 Rac1 与 Dock180 的相互作用,降低 Rac1-GTP水平。ZINC69391 诱导细胞凋亡,具有抗增殖和抗转移作用。

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ZINC69391 Chemical Structure

ZINC69391 Chemical Structure

CAS No. : 303094-67-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2420
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1 mg ¥1040
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5 mg ¥2200
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10 mg ¥3520
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25 mg ¥6336
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50 mg ¥8800
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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Ras 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects[1][2][3].

体外研究
(In Vitro)

ZINC69391 inhibits growth of U937, HL-60, KG1A and Jurkat cells with IC50s ranging from 41 to 54 μM[1].
ZINC69391 (50-100 μM; 24 hours) augments the enzymatic activity of caspase 3 in a concentration dependent manner[1].
ZINC69391 (0-125 μM; 72h) reduces cell proliferation of human glioma cells[2].
ZINC69391 (50-100 μM; 48 hours) triggers cell cycle arrest[2].
ZINC69391 (50 μM; 24 hours) triggers apoptosis on human acute leukemic cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: U-87 MG, LN229 cells
Concentration: 0-125μM
Incubation Time: 72 hours
Result: Reduced cell proliferation in a concentration-dependent manner.

Cell Cycle Analysis[2]

Cell Line: LN229 cells
Concentration: 50, 100 μM
Incubation Time: 48 hours
Result: Resulted in a significant increased percentage of cells in the sub-G0/G1 phase in a concentration dependent manner.

Apoptosis Analysis[1]

Cell Line: HL-60, U937 and KG1A cell lines
Concentration: 50 μM
Incubation Time: 24 hours
Result: Led to a significant increase in apoptotic cells.
体内研究
(In Vivo)

ZINC69391 (25 mg/kg; i.p; daily for 21 days) impairs metastatic lung colonization in a syngeneic animal model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific pathogen-free female BALB/c inbred mice (bearing F3II cells)[3]
Dosage: 25 mg/kg body weight
Administration: I.p; daily for 21 days
Result: Significantly reduced by about 60% the formation of total metastatic lung colonies.
分子量

309.29

Formula

C14H14F3N5

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 25 mg/mL (80.83 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2332 mL 16.1661 mL 32.3321 mL
5 mM 0.6466 mL 3.2332 mL 6.4664 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2332 mL 16.1661 mL 32.3321 mL 80.8303 mL
5 mM 0.6466 mL 3.2332 mL 6.4664 mL 16.1661 mL
10 mM 0.3233 mL 1.6166 mL 3.2332 mL 8.0830 mL
15 mM 0.2155 mL 1.0777 mL 2.1555 mL 5.3887 mL
20 mM 0.1617 mL 0.8083 mL 1.6166 mL 4.0415 mL
25 mM 0.1293 mL 0.6466 mL 1.2933 mL 3.2332 mL
30 mM 0.1078 mL 0.5389 mL 1.0777 mL 2.6943 mL
40 mM 0.0808 mL 0.4042 mL 0.8083 mL 2.0208 mL
50 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.6166 mL
60 mM 0.0539 mL 0.2694 mL 0.5389 mL 1.3472 mL
80 mM 0.0404 mL 0.2021 mL 0.4042 mL 1.0104 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ZINC69391
目录号:
HY-102078
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