1. NF-κB
    Autophagy
    Apoptosis
  2. Keap1-Nrf2
    Autophagy
    Apoptosis
  3. Danshensu

Danshensu (Synonyms: Dan shen suan A; Salvianic acid A)

目录号: HY-N1913 纯度: >98.0%
产品使用指南

Danshensu 是丹参的有效成分,能够激活 Nrf2 信号通路,保护心血管。

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Danshensu Chemical Structure

Danshensu Chemical Structure

CAS No. : 76822-21-4

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1  mL in Water ¥605 In-stock
10 mg ¥550 In-stock
50 mg ¥1200 In-stock
100 mg ¥1800 In-stock
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Other Forms of Danshensu:

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Description

Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

In Vitro

Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also has ROS scavenging activity and boosts endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blot analysis[2]

In Vivo

Acute treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. In contrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is via increased activity of the trans-sulphuration pathway[1].

Molecular Weight

198.17

Formula

C₉H₁₀O₅

CAS No.

76822-21-4

SMILES

OC1=C(O)C=CC(C[C@@H](O)C(O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (25.23 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0462 mL 25.2309 mL 50.4617 mL
5 mM 1.0092 mL 5.0462 mL 10.0923 mL
10 mM 0.5046 mL 2.5231 mL 5.0462 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
Animal Administration
[1]

All chemicals are dissolved in saline, except for tolcapone which is dissolved in saline containing 20% (v/v) PEG 200. During experiments, rats are fasted overnight and randomLy assigned into different groups. About 200 µL blood is taken from orbital sinus alternatively after ethyl ether anaesthesia, and then the eye is quickly sterilized with alcohol and pressed with cotton. Blood samples are immediately collected into a polypropylene tube containing heparin-Na and centrifuged at 5000 g at 5°C for 3 min. Prepared plasma samples are kept at −20°C and analysed within 48 h.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DanshensuDan shen suan ASalvianic acid AKeap1-Nrf2AutophagyApoptosisInhibitorinhibitorinhibit

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产品名称:
Danshensu
目录号:
HY-N1913
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