2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics Apoptosis
  3. Mitochondrial Metabolism Apoptosis AMPK
  4. Phenformin

Phenformin  (Synonyms: Phenethylbiguanide)

目录号: HY-16397
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Phenformin (1-phenethylbiguanide) 是一种具有口服活性的抗糖尿病和抗癌化合物。Phenformin 有相关乳酸性酸中毒的发生率。Phenformin 通过激活 AMPK 并阻断 mTOR 通路发挥作用。Phenformin 也是 P-糖蛋白 (P-gp) 的底物和 OXPHOS 抑制剂。Phenformin 诱导癌细胞凋亡 (apoptosis)。

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Phenformin Chemical Structure

Phenformin Chemical Structure

CAS No. : 114-86-3

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Phenformin 的其他形式现货产品:

Other Forms of Phenformin:

Phenformin 相关抗体

Top Publications Citing Use of Products

    Phenformin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Aug;128:110216.  [Abstract]

    Western blot analysis of p-AMPK, LC3B-I/II and NLRP3 after PSCs are pretreated with phenformin (Phe, AMPK activator) for 1 h followed by incubation with or without 10 μg/mL SSa for 24 h.

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    生物活性

    Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

    分子量

    205.26

    Formula

    C10H15N5
    CAS 号
    中文名称

    1-苯乙胺双胍
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Phenformin 相关分类

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    • 稀释计算器

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    Keywords:

    Phenformin114-86-3Phenethylbiguanide1-苯乙胺双胍Mitochondrial MetabolismApoptosisAMPKAMP-activated protein kinasetype 2 diabetes mellitusInhibitorinhibitorinhibit

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