2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Thioperamide

Thioperamide  (Synonyms: MR-12842)

目录号: HY-12206
产品使用指南

摩尔计算器

Thioperamide (MR-12842) 是一种有效的，具有口服活性的，可透过血脑屏障的选择性 H3 受体拮抗剂，抑制 [3H] 组胺释放的 Ki 为 4.3 nM。Thioperamide 抑制 [3H] 组胺合成的 Ki 为 31 nM 。

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Thioperamide Chemical Structure

Thioperamide Chemical Structure

CAS No. : 106243-16-7

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规格 价格 是否有货
5 mg ￥2077
3 - 4 周
10 mg ￥3326
3 - 4 周

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Thioperamide 相关抗体

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Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thioperamide (MR-12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4.3 nM for inhibition of [3H]histamine release. Thioperamide inhibits [3H]histamine synthesis with a Ki of 31 nM[1].

IC50 & Target[1]

H3 Receptor

 

体外研究
(In Vitro)

Thioperamide inhibits [3H]-(R)α-MeHA binding rat brain and guinea-pig lung with Kis of 2.1 nM and 2.0 nM, respectively. Thioperamide competitively blocks H3-autoreceptors regulating [3H]histamine release with a mean apparent Ki of 4 nM[1].
Thioperamide (0.01-100 μM; 24 hours) promotes the viability of NE-4C stem cells in a concentration-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thioperamide 相关抗体:

Cell Viability Assay[2]

Cell Line: NE-4C stem cells
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 24 hours
Result: The viability of NE-4C stem cells increased significantly to 150.83±6.91% when (1 μM) was administrated, and increased to 145.11±14.52% and 132.02%±25.65% when 10 μM and 100 μM were administrated respectively.
体内研究
(In Vivo)

Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naive female C57BL/6J mice[3]
Dosage: 5, 10 or 20 mg/kg
Administration: Injections (i.p.)
Result: Facilitated reconsolidation of a contextually-conditioned fear memory.
分子量

292.44

Formula

C15H24N4S
CAS 号
中文名称

硫丙咪胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thioperamide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thioperamide106243-16-7MR-12842硫丙咪胺MR12842MR 12842Histamine ReceptorH3receptorreleasehistaminesynthesisParkinsonInhibitorinhibitorinhibit

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