2. PI3K/Akt/mTOR Stem Cell/Wnt NF-κB Neuronal Signaling
  3. GSK-3 NF-κB Amyloid-β
  4. Cromolyn

Cromolyn  (Synonyms: 色甘酸; Cromoglycate; Cromoglicic acid; FPL-670 free acid)

目录号: HY-B1619 纯度: 99.91%
COA 产品使用指南 技术支持

Cromolyn (Cromoglycate) 是一种口服有效的 GSK-3β 抑制剂，IC50 为 2.0 μM。Cromolyn 也是一种肥大细胞稳定剂，能抑制肥大细胞释放介质、调节反射性支气管收缩和降低非特异性支气管高反应性，可用支气管哮喘的研究。此外，Cromolyn 还具有抗炎、抗过敏、抗组胺、抗肿瘤和神经保护等多种活性。

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Cromolyn

Cromolyn Chemical Structure

CAS No. : 16110-51-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥430
In-stock
100 mg ￥391
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500 mg   询价  

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Customer Review

Other Forms of Cromolyn:

Cromolyn 相关抗体

Top Publications Citing Use of Products

    Cromolyn purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.  [Abstract]

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

    查看 GSK-3 亚型特异性产品:

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    GSK-3 GSK-3α GSK-3β

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3][4][5].

    体外研究
    (In Vitro)

    Cromolyn (0-100 μM; 3-10 min) 在大鼠腹腔肥大细胞中，能抑制 IgE 和抗原诱导的脱颗粒及 PGD2 合成[1]。
    Cromolyn (0-100 μM; 0-72 h) 在 Panc-1 细胞中，可阻断 S100P 促进的细胞增殖、侵袭和 NF-κB 活性增加[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cromolyn 相关抗体:
    体内研究
    (In Vivo)

    Cromolyn (10 mg/kg; 静脉注射; 单剂量) 在大鼠中，可通过减少伊文思蓝外渗显著抑制 IgE 依赖性 PCA 中的肥大细胞激活，并完全抑制 PSA 中抗原诱导的血浆组胺增加[1]。
    Cromolyn (5 mg/kg; 腹腔注射; 5 周) 在胰腺癌小鼠模型具有抗肿瘤的活性[2]。
    Cromolyn (6.3 mg/kg; 腹腔注射; 每周 5 次; 从出生后第 60 天直至安乐死) 在肌萎缩侧索硬化症模型中具有改善作用[3]。
    Cromolyn (1-3.15 mg/kg; 腹腔注射; 每周 3 次; 12 周) 在阿尔兹海默症小鼠模型中具有神经保护的作用[4]。
    Cromolyn (1.43-5.72 mg/kg; 腹腔注射; 1 个月) 在小鼠中具有降血糖的作用[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male CB17 scid mice aged 4 weeks old treated BxPC-3 and MPanc-96 cells[2]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection; 5 weeks
    Result: Significantly reduced tumor burden.
    Reduced lung metastasis in the BxPC-3 model and both liver and lung metastases in the MPanc-96 model.
    Had no effect on body weight.
    Animal Model: SOD1G93A mice[3]
    Dosage: 6.3 mg/kg
    Administration: Intraperitoneal injection; 5 times a week; from postnatal day 60 until euthanasia
    Result: Delays disease onset.
    Improved motor deficits in the PaGE task.
    Increased survival of lumbar spinal cord motor neurons, decreased denervation at the neuromuscular junction.
    Reduced pro-inflammatory cytokine and chemokine levels in the spinal cord and plasma.
    Decreased mast cell degranulation in the tibialis anterior muscle.
    Animal Model: APPSwedish expressing Tg2576 mice[4]
    Dosage: 1 and 3.15 mg/kg
    Administration: Intraperitoneal injection; 3 times a week; 12 weeks
    Result: Reduced the levels of Aβ40 and Aβ42 in brain TBS-insoluble fractions.
    Increased the level of Aβ38.
    Promoted the phagocytosis of β-amyloid by microglia.
    Animal Model: Normal Balb/c mice, chronic type II diabetic Balb/c mice, and chronic obese Balb/c mice[5]
    Dosage: 1.43, 2.86 and 5.72 mg/kg
    Administration: Intraperitoneal injection; 1 month
    Result: Dose-dependently reducted blood glucose, body weight, and resistin levels.
    Increased liver glycogen, insulin, C-peptide, and adiponectin levels in mice.
    Clinical Trial
    分子量

    468.37

    Formula

    C23H16O11
    CAS 号
    性状

    固体

    颜色

    Off-white to light yellow

    中文名称

    色甘酸
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 175 mg/mL (373.64 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.1351 mL 10.6753 mL 21.3506 mL
    5 mM 0.4270 mL 2.1351 mL 4.2701 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Cromolyn 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1351 mL 10.6753 mL 21.3506 mL 53.3766 mL
    5 mM 0.4270 mL 2.1351 mL 4.2701 mL 10.6753 mL
    10 mM 0.2135 mL 1.0675 mL 2.1351 mL 5.3377 mL
    15 mM 0.1423 mL 0.7117 mL 1.4234 mL 3.5584 mL
    20 mM 0.1068 mL 0.5338 mL 1.0675 mL 2.6688 mL
    25 mM 0.0854 mL 0.4270 mL 0.8540 mL 2.1351 mL
    30 mM 0.0712 mL 0.3558 mL 0.7117 mL 1.7792 mL
    40 mM 0.0534 mL 0.2669 mL 0.5338 mL 1.3344 mL
    50 mM 0.0427 mL 0.2135 mL 0.4270 mL 1.0675 mL
    60 mM 0.0356 mL 0.1779 mL 0.3558 mL 0.8896 mL
    80 mM 0.0267 mL 0.1334 mL 0.2669 mL 0.6672 mL
    100 mM 0.0214 mL 0.1068 mL 0.2135 mL 0.5338 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cromolyn16110-51-3Cromoglycate Cromoglicic acidFPL-670色甘酸FPL670FPL 670GSK-3NF-κBAmyloid-βGlycogen synthase kinase-3Glycogen synthase kinase 3Nuclear factor-κBNuclear factor-kappaBβ-amyloid peptideAβAbetapancreatic cancer modelamyotrophic lateral sclerosis modelAlzheimer's disease modelrat peritoneal mast cellsPanc-1 cellsInhibitorinhibitorinhibit

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