2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. HDAC MMP HIF/HIF Prolyl-Hydroxylase
  4. HNHA

HNHA 是一种有效的组蛋白去乙酰化酶 (HDAC)抑制剂。HNHA 通过 p21 诱导在 G1/S 期阻滞细胞周期。HNHA 可抑制肿瘤生长和抑制肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌剂。

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HNHA Chemical Structure

HNHA Chemical Structure

CAS No. : 926908-04-5

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规格 价格 是否有货
2 mg ￥1311
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HNHA 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HNHA is a potent histone deacetylase (HDAC) inhibitor. HNHA arrests the cell cycle at the G1/S phase via p21 induction. HNHA inhibits tumor growth and tumor neovascularization. HNHA may be a potent anti-cancer agent against breast cancer[1].

IC50 & Target

MMP-2

 

MMP-9

 

体外研究
(In Vitro)

HNHA (0-100 μM, 96 h) shows strong inhibition at lower concentrations on cancer cell lines, especially on breast cancer cells, mouse FM3A and human MCF-7[1].
HNHA (15 μM, 24 h) arrests cancer cells at the G1/S phase of the cell cycle, activates p21and rescues strongly protein acetylation[1].
HNHA (15 μM, 12 h) inhibits angiogenic proteins in breast cancer cells, effectively inactivates MMP-2, MMP-9, VEGF and HIF-1α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HNHA 相关抗体:

Cell Proliferation Assay

Cell Line: FM3A, C1300, LA-N-1, LA-N-2, LA-N-5, NB16, NB19, NB69, SK-N-SH, MCF-7 and HT-29[1]
Concentration: 0-100 μM
Incubation Time: 96 h
Result: Showed strong inhibition at lower concentrations on all cancer cell lines (FM3A, C1300, LA-N-1, LA-N-2, LA-N-5, NB16, NB19, NB69, SK-N-SH, MCF-7 and HT-29), with IC50 values of 15.70, 55.63, 22.78, 23.18, 26.70, 19.64, 21.26, 22.31, 65.09, 14.33, and 16.98 μM, respectively.

Cell Viability Assay

Cell Line: FM3A and MCF-7[1]
Concentration: 0, 0.1, 1, 5, 10, 15, 20, 25,30 μM
Incubation Time: 48 h
Result: Showed dose-dependent inhibition of viability in mouse and human breast cancer cells.

Cell Cycle Analysis

Cell Line: FM3A and MCF-7 cells[1]
Concentration: 15 μM
Incubation Time: 24 h
Result: Arrested FM3A and MCF-7 cells in the G1/S phase.

Western Blot Analysis

Cell Line: FM3A and MCF-7 cells[1]
Concentration: 0, 0.1, 1, 10, and 20 μM (24 h)
Incubation Time: 1, 6, 24, 48, and 72 h (15 μM)
Result: Activated a cell proliferation arrestor p21, increased histone and non-histone protein acetylation and inhibited FM3A and MCF-7 proliferation in vitro, and was very effective in increasing the acetylation level of histone H3 protein in FM3A and MCF-7. The most effective dose point for acetylation of histone H3 was 10-20 μM. Histone H3 acetylation peaked after 1 h of exposure to the drugs and remained stable for 1-6 h.

Western Blot Analysis

Cell Line: FM3A and MCF-7 cells[1]
Concentration: 15 μM
Incubation Time: 12 h
Result: Showed a strong induction of TIMP-1 and TIMP-2, and effectively inactivated MMP-2, MMP-9, VEGF and HIF-1α.
体内研究
(In Vivo)

HNHA (20 μM/mouse, IP, once every 2 days for a total of six injections) reduces tumor burden and extends the survival rate, activates TIMP-1, TIMP-2 and p21 and inhibits MMP-2, MMP-9, HIF-1α and VEGF protein expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeJ-FasL mice (FM3A breast cancer cell tumor xenograft, 6 weeks, n = 25/group)[1]
Dosage: 20 μM/mouse
Administration: IP, once every 2 days for a total of six injections
Result: Reduced tumor burden and extended the survival rate. Effectively inhibited cancer development and angiogenesis in vivo. Increased TIMP-1, TIMP-2 and p21, decreased MMP-2, MMP-9, HIF-1α and VEGF protein expression, and reduced the distribution of CD34, HIF-1α and VEGF.
分子量

303.42

Formula

C17H21NO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HNHA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HNHA926908-04-5HDACMMPHIF/HIF Prolyl-HydroxylaseHistone deacetylasesMatrix metalloproteinasesHypoxia-inducible factorsHIFsHIF-PHAnti-cancer activityBreast cancerFM3A cellsMCF-7 cellsInhibitorinhibitorinhibit

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目录号：
HY-118672
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