1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Cell Cycle/DNA Damage
  2. EGFR
    CDK
  3. AG-494

AG-494 (Synonyms: Tyrphostin AG 494)

目录号: HY-101042
产品使用指南

AG-494 (Tyrphostin AG 494) 是一种高效、选择性的 EGFR 酪氨酸激酶抑制剂 (IC50=0.7 μM)。AG-494 抑制EGFR、ErbB2、HER1-2 和 PDGF-R 的自磷酸化,IC50 为 1.1,39,45 和 6 μM。AG-494 阻断 Cdk2 的激活并抑制 EGF 依赖的 DNA 合成。

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AG-494 Chemical Structure

AG-494 Chemical Structure

CAS No. : 133550-35-3

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Description

AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].

IC50 & Target[1][2]

EGFR

0.7 μM (IC50)

In Vitro

In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis[2].
AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells[4].
AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner[5].

Molecular Weight

280.28

Formula

C₁₆H₁₂N₂O₃

CAS No.

133550-35-3

SMILES

O=C(NC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

AG-494Tyrphostin AG 494AG494AG 494Tyrphostin AG494Tyrphostin AG-494EGFRCDKEpidermal growth factor receptorErbB-1HER1Cyclin dependent kinaseautophosphorylationCdk2activationDNAsynthesisosteogenicdifferentiationInhibitorinhibitorinhibit

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产品名称:
AG-494
目录号:
HY-101042
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