1. MAPK/ERK Pathway
    NF-κB
  2. p38 MAPK
    NF-κB
  3. Cornuside

Cornuside 

目录号: HY-N0631
产品使用指南

Cornuside 是一种从山茱萸 (Cornus officinalis Sieb. et Zucc.) 的果实中分离出的环烯醚萜苷,山茱萸是一种传统的东方医药,用于治疗炎症性疾病和促进血液循环。 Cornuside 通过下调 MAPKNF-κB 信号通路抑制肥大细胞介导的过敏反应。Cornuside 的体内和体外抗过敏作用表明该药物在炎性过敏性疾病中的治疗应用。

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Cornuside Chemical Structure

Cornuside Chemical Structure

CAS No. : 131189-57-6

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Description

Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1].

IC50 & Target[1]

p38 MAP kinase

 

NF-κB

 

Molecular Weight

542.49

Formula

C₂₄H₃₀O₁₄

CAS No.

131189-57-6

SMILES

O=C(C1=CC(O)=C(O)C(O)=C1)OCCC(C(C(OC)=O)=COC2OC(C(C(O)C3O)O)OC3CO)C2C=C

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Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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× = ×
C1   V1   C2   V2

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产品名称:
Cornuside
目录号:
HY-N0631
需求量:

Cornuside

Cat. No.: HY-N0631