2. Gene
  3. GMPS - guanine monophosphate synthase Gene

GMPS - guanine monophosphate synthase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟嘌呤单磷酸合酶

种属: Homo sapiens

同用名: GATD7

基因 ID: 8833 | 基因类型: protein coding

关于 GMPS

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:155,869,430-155,944,020 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and is associated with 60 phenotypes. Broad expression in testis (RPKM 20.3), thyroid (RPKM 6.3) and 25 other tissues.

功能概要

在嘌呤核苷酸的从头合成中，IMP 是分支点代谢物，在该点途径分支为鸟嘌呤或腺嘌呤核苷酸的合成。在鸟嘌呤核苷酸途径中，有 2 种酶参与将 IMP 转化为 GMP，即 IMP 脱氢酶 (IMPD1) ，催化 IMP 氧化为 XMP；GMP 合成酶，催化 XMP 胺化为 GMP。[RefSeq 提供，2008 年 7 月]

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

GMPS 基因产物(1)

mRNA Protein Name
NM_003875.3 NP_003866.1 GMP synthase [glutamine-hydrolyzing]

GMPS 蛋白结构

GATase

GATase: Glutamine amidotransferase class-I (29 - 208)

NAD_synthase

NAD_synthase: NAD synthase (224 - 302)

GMP_synt_C

GMP_synt_C: GMP synthase C terminal domain (493 - 692)

  • 0
  • 200
  • 400
  • 600
  • 693 a.a.
蛋白主名 其他名称

GMP synthase [glutamine-hydrolyzing]

GMP synthase

关联疾病

疾病名称 别名
Thiopurines, Poor Metabolism Of, 1

Thiopurine S-Methyltransferase Deficiency

Tpmt Deficiency

Thiopurine Methyltransferase Deficiency

Thiopurine S Methyltranferase Deficiency

THPM1

Tpmtd

Poor Metabolism Of Thiopurines-1

6-Mercaptopurine Sensitivity

Thiopurines, Poor Metabolism Of

Poor Metabolism Of Thiopurines
Orotic Aciduria

Hereditary Orotic Aciduria

Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency

Uridine Monophosphate Synthase Deficiency

Umps Deficiency

Uridine Monophosphate Synthetase Deficiency

Orotic Aciduria I

Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency

Oprt And Odc Deficiency

Ump Synthase Deficiency

Orotic Aciduria Ii

Oroticaciduria 1

Orotic Aciduria Hereditary

Orotic Aciduria Type 1

Hereditary Orotic Aciduria Without Megaloblastic Anemia

Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency

Ump Synthtase Deficiency

Umps

Orotidylic Decarboxylase Deficiency

Orotic Aciduria 1

ORAC1

Aciduria, Orotic

Hereditary Orotic Aciduria, Type 1

Orotic Aciduria Nos

Orotaciduric Anaemia

Orotic Aciduria Anaemia

Orotic Aciduria Megaloblastic Anaemia
Pyrimidine Metabolic Disorder

Disorder Of Pyrimidine Metabolism

Pyrimidine Metabolism Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1730 Phensuximide 99.35% 否
Clinical Phase
生物活性分子 (11)
目录号 产品名 作用方式
纯度 Phase
HY-101952G Prostaglandin E2 (GMP) / Phase 4
HY-10219G Rapamycin (GMP) Inhibitor / Phase 4
HY-50895G Gefitinib (GMP) / Phase 4
HY-18085G Quercetin (GMP) / Phase 4
HY-13631AG Exatecan mesylate (GMP) Inhibitor / Phase 3
HY-14649G Retinoic acid (GMP) Agonist / Phase 3
HY-50751G Linifanib (GMP) Inhibitor / Phase 3
HY-17500 Ataciguat Activator 99.81% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-B0166G L-Ascorbic acid (GMP) Inhibitor / Phase 2
HY-10254G Mirdametinib (GMP) Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (119)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10182 Laduviglusib 99.76% 否
HY-114180 RU.521 Inhibitor 99.89% 否
HY-100564A 2',3'-cGAMP sodium Activator 99.89% 否
HY-100564 2',3'-cGAMP Activator 99.71% 否
HY-110385 cGAMP disodium Activator 99.34% 否
HY-128583 G150 Inhibitor 98.61% 否
HY-133916 G140 Inhibitor 98.11% 否
HY-12512 cGAMP Activator 99.22% 否
HY-110382 Cyclic-di-GMP disodium Activator 99.23% 否
HY-107780B Cyclic-di-GMP diammonium Activator 99.72% 否
HY-114182 PF-06928215 Inhibitor 99.69% 否
HY-101835 Decoyinine Inhibitor 99.96% 否
HY-N5134 5'-Guanylic acid 99.61% 否
HY-10583G Y-27632 dihydrochloride (GMP) Inhibitor / 否
HY-10182G Laduviglusib (GMP) / 否
HY-W010970 5'-Guanylic acid disodium salt ≥98.0% 否
HY-111673 8-CPT-Cyclic AMP sodium 99.92% 否
HY-10431G SB-431542 (GMP) Inhibitor / 否
HY-137662 5'-Phosphoguanylyl-(3',5')-guanosine 90.37% 否
HY-12379 NS-2028 Inhibitor 99.65% 否
HY-N1469 Kaurenoic acid 99.56% 否
HY-113469A Cyclic GMP sodium 99.86% 否
HY-13012G RepSox (GMP) Inhibitor / 否
HY-114181 IRAK4-IN-4 Inhibitor 99.85% 否
HY-110385A cGAMP diammonium Activator 95.19% 否
HY-119611A Thioquinapiperifil dihydrochloride Inhibitor 99.22% 否
HY-50723 3-Methylxanthine 99.62% 否
HY-P0229 Ribonulease T1, Aspergillus oryzae / 否
HY-13257G Thiazovivin (GMP) Inhibitor / 否
HY-100933 MY-5445 Inhibitor 99.86% 否
HY-107780 Cyclic-di-GMP Activator 98.18% 否
HY-15147G XAV-939 (GMP) Inhibitor / 否
HY-15575G VcMMAE (GMP) / 否
HY-114548 Ebselen oxide Inhibitor ≥98.0% 否
HY-119819 Psicofuranine Inhibitor ≥98.0% 否
HY-B0166GL L-Ascorbic acid (GMP Like) 99.88% 否
HY-123468 HA-1004 Inhibitor 99.03% 否
HY-10432G A 83-01 (GMP) Inhibitor / 否
HY-10475G AM580 (GMP) Agonist / 否
HY-113469B Cyclic GMP (TBAOH) 99.07% 否
HY-100164 SDZ-MKS 492 Inhibitor 98.07% 否
HY-115745 Calmodulin antagonist-1 Antagonist ≥98.0% 否
HY-160546 cGAS-IN-2 Inhibitor / 否
HY-50723S 3-Methylxanthine-13C4,15N3 / 否
HY-B0185G Lidocaine (GMP) / 否
HY-P1179 Guanylin(human) Activator / 否
HY-P1179A Guanylin(human) TFA Activator 95.31% 否
HY-15764G A 419259 (GMP) / 否
HY-10182C Laduviglusib dihydrochloride / 否
HY-10219GL Rapamycin (GMP Like) Inhibitor / 否
HY-12071G LDN193189 (GMP) Inhibitor / 否
HY-12318G IBMX (GMP) Inhibitor / 否
HY-13027G DAPT (GMP) Inhibitor / 否
HY-13418G Dorsomorphin dihydrochloride (GMP) Inhibitor / 否
HY-15141G Staurosporine (GMP) Inhibitor / 否
HY-15162G Monomethyl auristatin E (GMP) / 否
HY-15582G Auristatin E (GMP) Inhibitor / 否
HY-78931G Boc-Dap-NE (GMP) / 否
HY-10407G SU 5402 (GMP) Inhibitor / 否
HY-12186G 3-Deazaneplanocin A hydrochloride (GMP) Inhibitor / 否
HY-12323G ISX-9 (GMP) Activator / 否
HY-13319G JNK-IN-8 (GMP) Inhibitor / 否
HY-13526G YO-01027 (GMP) Inhibitor / 否
HY-13912G IWP-2 (GMP) Inhibitor / 否
HY-14398GL Celecoxib (GMP Like) Inhibitor / 否
HY-15108G Purmorphamine (GMP) Agonist / 否
HY-15578G McMMAF (GMP) / 否
HY-15579BG MMAF sodium (GMP) Inhibitor / 否
HY-15579G MMAF (GMP) Inhibitor / 否
HY-15659G Wnt-C59 (GMP) Inhibitor / 否
HY-16700G PNU-159682 (GMP) Inhibitor / 否
HY-U00449G AGN 193109 (GMP) Antagonist / 否
HY-100374G Val-Cit-PAB-MMAE (GMP) / 否
HY-106235 LB80317 Inhibitor / 否
HY-107780A Cyclic-di-GMP sodium Activator / 否
HY-119611 Thioquinapiperifil Inhibitor / 否
HY-119808 Terrein / 否
HY-12362G Val-cit-PAB-OH (GMP) / 否
HY-128790S1 4-Methoxyestrone-13C6 / 否
HY-131833G Fmoc-Gly-Gly-Phe-OH (GMP) / 否
HY-131990G MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) / 否
HY-135110 Rp-8-Br-cGMPS sodium salt Activator / 否
HY-14397G Indomethacin (GMP) Inhibitor / 否
HY-14398G Celecoxib (GMP) Inhibitor / 否
HY-149526 cGAS-IN-1 Inhibitor / 否
HY-15150G Bemcentinib (GMP) Inhibitor / 否
HY-155337 eIF4E-IN-6 / 否
HY-156087G Cholicamideβ (GMP) Inducer / 否
HY-15682G TTNPB (GMP) Agonist / 否
HY-15794G Nemorubicin (GMP) / 否
HY-162459 cGAS-IN-3 Inhibitor / 否
HY-16910G WIKI4 (GMP) / 否
HY-17356G Fenofibrate (GMP) / 否
HY-17447AG Tranylcypromine hydrochloride (GMP) Inhibitor / 否
HY-19318G Fmoc-Val-Cit-PAB (GMP) / 否
HY-20336G Mc-Val-Cit-PABC-PNP (GMP) / 否
HY-42972G DBCO-acid (GMP) / 否
HY-44980G Fmoc-Gly-NH-CH2-acetyloxy (GMP) / 否
HY-45672G Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) / 否
HY-50723R 3-Methylxanthine (Standard) / 否
HY-78736G Val-Cit-PAB-OSBT (GMP) / 否
HY-78738G MC-Val-Cit-PAB (GMP) / 否
HY-78921AG Fmoc-3VVD-OH (GMP) / 否
HY-B0434G Ribavirin (GMP) Inhibitor / 否
HY-B0450AG Ciclopirox olamine (GMP) Inhibitor / 否
HY-B0497G Niclosamide (GMP) Inhibitor / 否
HY-D1185 2'-Fluo-AHC-c-di-GMP / 否
HY-D1185A 2'-Fluo-AHC-c-di-GMP sodium / 否
HY-N5134S1 5'-Guanylic acid-13C10 dilithium / 否
HY-P5072 GRP (14-27) (human, porcine, canine) Agonist / 否
HY-RS05528 GMPS Human Pre-designed siRNA Set A / 否
HY-W000423G DBCO-amine (GMP) / 否
HY-111582G BBIQ (GMP) Agonist / 否
HY-160197G Aluminum phosphate adjuvant (GMP) Activator / 否
HY-50723S1 3-Methylxanthine-d3 / 否
HY-N5134S2 5'-Guanylic acid-15N5 dilithium ≥95.0% 否
HY-N5134S3 5'-Guanylic acid-d12 dilithium / 否
HY-N5134S4 5'-Guanylic acid-15N5,d12 dilithium / 否
HY-N5134S5 5'-Guanylic acid-13C10,15N5 dilithium / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GMPS VGNC VGNC:29443
Canis familiaris GMPS VGNC VGNC:41296
Macaca mulatta GMPS VGNC VGNC:73084
Mus musculus GMPS MGD MGI:2448526
Felis catus GMPS VGNC VGNC:62614
Rattus norvegicus GMPS RGD RGD:1310063
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