2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 8

GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物，是有效和选择性的 GSK-3β 抑制剂 (IC50=64 nM)。GSK-3β inhibitor 8 负调控 Wnt 信号通路，刺激 β 细胞增殖。

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GSK-3β inhibitor 8 Chemical Structure

GSK-3β inhibitor 8 Chemical Structure

CAS No. : 1139875-74-3

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规格 价格 是否有货 数量
1 mg ￥929
3 - 4 周
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GSK-3β inhibitor 8 相关抗体

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].

IC50 & Target[1]

GSK-3β

64 nM (IC50)

体外研究
(In Vitro)

GSK-3β inhibitor 8 (化合物 1a) (1 nM-100 μM; 7 d) 剂量依赖性地刺激 β 细胞增殖，EC50 值为 1.41 μM。GSK-3β inhibitor 8 (2 μM; 72 h) 使复制 R7T1 β 细胞增加约 2 倍[1]。
GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) 诱导 Super (8X) TOPFlash 报告晶活化，EC50 值为 1.25 μM[1]。
GSK-3β inhibitor 8 (2 μM; 72 h) 刺激 HEK293 细胞 β-catenin 转位进入细胞核[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK-3β inhibitor 8 相关抗体:
分子量

413.92

Formula

C20H20ClN5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK-3β inhibitor 8 相关分类

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Keywords:

GSK-3β inhibitor 81139875-74-3GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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