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  3. YM-298198 hydrochloride

YM-298198 hydrochloride 

目录号: HY-103568
产品使用指南

YM-298198 hydrochloride 是高亲和力、选择性、非竞争性的 mGluR1 的拮抗剂。YM-298198 hydrochloride 可用于神经系统疾病的研究。

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YM-298198 hydrochloride Chemical Structure

YM-298198 hydrochloride Chemical Structure

CAS No. : 1216398-09-2

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Description

YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders[1].

IC50 & Target[1]

mGluR 1

 

In Vitro

YM-298198 hydrochloride shows a high affinity for mGluR1 with a Ki of 19 nM for rat mGluR1-NIH membranes[1].
YM-298198 hydrochloride inhibits glutamate-induced inositol phosphate production in mGluR1-NIH3T3 cells with an IC50 of 16 nM[1].
YM-298198 hydrochloride shows neither agonistic nor antagonistic activity on mGluR2, 3, 4a, 6, or 7b up to 10 μM[1].

In Vivo

YM-298198 hydrochloride (30 mg/kg; p.o.) shows a significant analgesic effect in streptozotocin-induced hyperalgesic mice[1].

Animal Model: Male ICR mice[1]
Dosage: 30 mg/kg
Administration: Oral administration
Result: Prolonged nociceptive response latency in streptozotocin (200 mg/kg)-induced hyperalgesic mice.
Molecular Weight

378.92

Formula

C₁₈H₂₃ClN₄OS

CAS No.

1216398-09-2

SMILES

O=C(C1=C(C)N2C3=CC(N)=CC=C3N=C2S1)N(C4CCCCC4)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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  • 稀释计算器

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Keywords:

YM-298198YM298198YM 298198mGluRMetabotropic glutamate receptorsneurologicaldisordersneurotransmissionmetabotropicglutamatereceptorInhibitorinhibitorinhibit

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产品名称:
YM-298198 hydrochloride
目录号:
HY-103568
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