2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Autophagy Apoptosis
  3. DNA/RNA Synthesis Akt mTOR Autophagy Apoptosis
  4. 8-Aminoadenosine

8-Aminoadenosine  (Synonyms: 8-氨基腺苷; 8-NH2-Ado)

目录号: HY-125927 纯度: 99.94%
COA 产品使用指南

摩尔计算器

8-Aminoadenosine (8-NH2-Ado) 是一种 RNA 导向的核苷类似物，可降低细胞 ATP 水平并抑制 mRNA 合成。8-Aminoadenosine 阻断 Akt/mTOR 信号，并诱导 p53 非依赖性的自噬和细胞凋亡。8-Aminoadenosine 具有抗肿瘤活性。

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8-Aminoadenosine Chemical Structure

8-Aminoadenosine Chemical Structure

CAS No. : 3868-33-5

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25 mg ￥2000
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50 mg ￥3200
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Customer Review

8-Aminoadenosine 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity[1][2][3].

IC50 & Target[1][2]

mTOR

 

体外研究
(In Vitro)

8-Aminoadenosine (8-NH2-Ado; 0.1-10 μM; for 48 h) has IC50s of 1.5 μM and 8.88 μM in MM.1S and U266 cells, respectively[1].
8-Aminoadenosine (10 μM; for 24 h) induces significant apoptotic death of MCF-7 cells in p53-independent pathway. 8-Aminoadenosine causes PARP cleavage in MCF-7 cells[2].
8-Aminoadenosine (3 μM; 0.5-4 h) induces autophagy in the MM.1S cell line[1].
8-Aminoadenosine (3 μM; 2-16 h) causes a greater drop in ATP levels in the MM.1S cells[1].
8-Aminoadenosine (3 μM; 5 h) causes a 50% reduction in glucose consumption in MM.1S cells[1].
8-Aminoadenosine (3 μM; 5 h) indicates a time-dependent decrease in GLUT1 expression at 5 h, whereas at 24 h there was a down-regulation of both transporters (GLUT1 and GLUT4) in MM.1S cells[1].
8-Aminoadenosine inhibits cell proliferation, activated cell death, and does not activate transcription of the p53 target gene p21 or increase protein levels of either p53 or p21[1].
The toxic effects of 8-Aminoadenosine require adenosine kinase activity to convert 8-Aminoadenosine to 8-NH2-ATP in adenosine kinase-deficient cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-Aminoadenosine 相关抗体:

Cell Viability Assay[1]

Cell Line: MM.1S and U266 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: For 48 hours
Result: Had IC50s of 1.5 μM and 8.88 μM in MM.1S and U266 cells, respectively.

Apoptosis Analysis[2]

Cell Line: MCF-7 cells
Concentration: 10 μM
Incubation Time: For 24 hours
Result: Induced significant apoptotic death.
Apoptosis was not inhibited by knockdown of functional p53.

Apoptosis Analysis[1]

Cell Line: MM.1S cell line
Concentration: 3 μM
Incubation Time: 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours
Result: Induced the formation of LC3-II protein.
Caused the appearance of a population with a high AVO content with 1 μM for 24 hours.
分子量

282.26

Formula

C10H14N6O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

8-氨基腺苷；8-氨基腺苷酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 83.33 mg/mL (295.22 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5428 mL 17.7142 mL 35.4283 mL
5 mM 0.7086 mL 3.5428 mL 7.0857 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

8-Aminoadenosine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5428 mL 17.7142 mL 35.4283 mL 88.5708 mL
5 mM 0.7086 mL 3.5428 mL 7.0857 mL 17.7142 mL
10 mM 0.3543 mL 1.7714 mL 3.5428 mL 8.8571 mL
15 mM 0.2362 mL 1.1809 mL 2.3619 mL 5.9047 mL
20 mM 0.1771 mL 0.8857 mL 1.7714 mL 4.4285 mL
25 mM 0.1417 mL 0.7086 mL 1.4171 mL 3.5428 mL
30 mM 0.1181 mL 0.5905 mL 1.1809 mL 2.9524 mL
40 mM 0.0886 mL 0.4429 mL 0.8857 mL 2.2143 mL
50 mM 0.0709 mL 0.3543 mL 0.7086 mL 1.7714 mL
60 mM 0.0590 mL 0.2952 mL 0.5905 mL 1.4762 mL
80 mM 0.0443 mL 0.2214 mL 0.4429 mL 1.1071 mL
100 mM 0.0354 mL 0.1771 mL 0.3543 mL 0.8857 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Aminoadenosine3868-33-58-NH2-Ado8-氨基腺苷8-氨基腺苷酸DNA/RNA SynthesisAktmTORAutophagyApoptosisPKBProtein kinase BMammalian target of RapamycinRNAnucleosideATPp53MM.1SU266MCF-7Inhibitorinhibitorinhibit

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