2. Membrane Transporter/Ion Channel Neuronal Signaling Autophagy Immunology/Inflammation GPCR/G Protein
  3. TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)
  4. EIPA hydrochloride

EIPA hydrochloride  (Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride)

目录号: HY-101840A 纯度: 99.92%
COA 产品使用指南

摩尔计算器

EIPA (L593754) hydrochloride 是一种具有口服活性的 TRPP3 通道抑制剂，IC50 为 10.5 μM。EIPA hydrochloride 可通过抑制 Na+/H+-exchanger 3 (NHE3) 来促进自噬 (autophagy)。EIPA hydrochloride 也抑制巨胞饮作用 (macropinocytosis)。EIPA hydrochloride 可用于炎症和癌症的研究，如胃癌、结肠癌、胰腺癌。

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EIPA hydrochloride Chemical Structure

EIPA hydrochloride Chemical Structure

CAS No. : 1345839-28-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1089
In-stock
5 mg ￥990
In-stock
10 mg ￥1600
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of EIPA hydrochloride:

EIPA hydrochloride 相关抗体

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MCE 顾客使用本产品发表的 40 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][5].

IC50 & Target[7]

COX-2

 

体外研究
(In Vitro)

EIPA hydrochloride (100 μM, 30 min) suppresses TRPP3-mediated Ca2+ uptake in X. laevis oocytes[1].
? EIPA hydrochloride (10-100 μM) reversibly inhibits the basal Na+ current (IC50: 19.5 μM)[1].
? EIPA hydrochloride (300 μM, 6h) enhances autophagy through NHE3 (Na+/H+-exchanger 3) in IEC-18 cells[2].
? EIPA hydrochloride (20 μM, 2 h) blocks macropinocytosis-mediated uptake of CA-PZ massively entry in HT-29 cells and MIA PaCa-2 cells[3].
? EIPA hydrochloride (30 μM, 3h) attenuates Zinc/Kainate toxicity by decreasing Zn2+ entry in cerebellar granule neurons[4].
? EIPA hydrochloride (5-100 μM, 48h) suppresses proliferation of MKN28 cells through up-regulation of p21 expression[5].
? EIPA hydrochloride (3 μM, 6 h) inhibits the LPS-induced increase in the level of COX-2 protein[7].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EIPA hydrochloride 相关抗体:

Cell Proliferation Assay[5]

Cell Line: MKN28 cells
Concentration: 5, 10, 25, 50, and 100 μM
Incubation Time: 48 h
Result: Inhibited cell proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: IEC-18 cells
Concentration: 300 μM
Incubation Time: 6 h
Result: Increased total LC3-II protein levels and P62 flux.
Increased ATG5, 7, 12 and P62 expression.
体内研究
(In Vivo)

EIPA hydrochloride (Intravenous injection, 1 mg/kg) dose-dependently attenuates the I/R (Ischemia/reperfusion)-induced renal dysfunction in ddY strain mice[6].
? EIPA hydrochloride (oral administration, 10 mg/kg) inhibits LPS-induced inflammation in air pouch-type LPS-induced inflammation model[7].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY strain mice[6]
Dosage: 1 mg/kg
Administration: Intravenous injection
Result: Attenuated histologic renal damage, and imprved the I/R-induced increases in renal ET-1 contents.
Animal Model: Air pouch-type LPS-induced inflammation model[7]
Dosage: 10 mg/kg
Administration: Oral administration
Result: Inhibited the LPS-induced infiltration of leukocytes into the pouch.
Inhibited the amount of PGE2 in the pouch fluid.
分子量

336.22

Formula

C11H19Cl2N7O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 130 mg/mL (386.65 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9742 mL 14.8712 mL 29.7424 mL
5 mM 0.5948 mL 2.9742 mL 5.9485 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

EIPA hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9742 mL 14.8712 mL 29.7424 mL 74.3561 mL
5 mM 0.5948 mL 2.9742 mL 5.9485 mL 14.8712 mL
10 mM 0.2974 mL 1.4871 mL 2.9742 mL 7.4356 mL
15 mM 0.1983 mL 0.9914 mL 1.9828 mL 4.9571 mL
20 mM 0.1487 mL 0.7436 mL 1.4871 mL 3.7178 mL
25 mM 0.1190 mL 0.5948 mL 1.1897 mL 2.9742 mL
30 mM 0.0991 mL 0.4957 mL 0.9914 mL 2.4785 mL
40 mM 0.0744 mL 0.3718 mL 0.7436 mL 1.8589 mL
50 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.4871 mL
60 mM 0.0496 mL 0.2479 mL 0.4957 mL 1.2393 mL
80 mM 0.0372 mL 0.1859 mL 0.3718 mL 0.9295 mL
100 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.7436 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EIPA1345839-28-2L593754MH 12-43EthylisopropylamilorideL 593754L-593754TRP ChannelAutophagyCOXProstaglandin ReceptorNa+/H+ Exchanger (NHE)Transient receptor potential channelsCyclooxygenaseSodium/hydrogen ExchangerSodium-hydrogen ExchangerCation channelNHE3IECsIBDsIEC-18neuronzinccalciumkainiteMKN28gastric cancercolon carcinomapancreatic carcinomarenal failureddY strain miceInhibitorinhibitorinhibit

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目录号：
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