2. Gene
  3. Kras - KRAS proto-oncogene, GTPase Gene

Kras - KRAS proto-oncogene, GTPase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：KRAS 原癌基因，GTP 酶

种属: Rattus norvegicus

同用名: p21; Kras2; c-Ki-ras

基因 ID: 24525 | 基因类型: protein coding

关于 Kras

Biased expression in Lung (RPKM 85.5), Thymus (RPKM 74.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 GDP 绑定活动； GMP结合活性；和 LRR 域绑定活动。参与多个过程，包括 NF-kappaB 转录因子活性的正调控；细胞衰老的正向调节；和对皮质类固醇的反应。位于膜筏和线粒体中。用于研究细支气管肺泡腺癌；子宫内膜腺癌；肝细胞腺瘤；肝细胞癌；和肾纤维化。该基因的人类直系同源物与多种疾病有关，包括努南综合征（多种）；脑动静脉畸形;心面皮肤综合征（多发性）；胃肠系统癌症（多发性）；和血液系统癌症（多种）。与人类 KRAS 同源（KRAS 原癌基因，GTPase）。 [由基因组资源联盟提供，2022 年 4 月]

Enables GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cellular senescence; and response to corticosteroid. Located in membrane raft and mitochondrion. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Kras 基因产物(1)

mRNA Protein Name
NM_031515.3 NP_113703.1 GTPase KRas
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
12594205 RGD
enables GMP binding IDA
IDA: 通过直接分析推断
12594205 RGD
enables LRR domain binding IDA
IDA: 通过直接分析推断
12594205 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19319189 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac muscle cell proliferation IEP
IEP: 通过表达模式推断
2447874 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
14576830 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
1570348 RGD
involved in liver development IEP
IEP: 通过表达模式推断
1526114 RGD
involved in myoblast proliferation IEP
IEP: 通过表达模式推断
2425941 RGD
involved in positive regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
10969813 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
14576830 RGD
involved in positive regulation of cellular senescence IMP
IMP: 通过突变表型推断
17706954 RGD
involved in positive regulation of nitric-oxide synthase activity IMP
IMP: 通过突变表型推断
14576830 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
1420288 RGD
involved in response to gravity IEP
IEP: 通过表达模式推断
14638460 RGD
involved in response to isolation stress IEP
IEP: 通过表达模式推断
19616040 RGD
involved in response to mineralocorticoid IEP
IEP: 通过表达模式推断
16543373 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Kras 蛋白结构

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 189 a.a.
蛋白主名 其他名称

GTPase KRas

K-Ras 2

Kirsten rat sarcoma viral oncogene homolog

Kirsten rat sarcoma viral oncogene homologue 2 (active)

c-K-ras

c-K-ras2 protein

c-Kirsten-ras proto-oncogene

ki-Ras

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-114277 Sotorasib Inhibitor 99.75% 是
HY-130149 Adagrasib Inhibitor 99.79% 否
HY-15136 Lonafarnib 99.85% 是
HY-114277A Sotorasib racemate 98.99% 否
HY-B0984 Fendiline hydrochloride 99.78% 否
HY-B0984A Fendiline 99.41% 否
Clinical Phase
生物活性分子 (18)
目录号 产品名 作用方式
纯度 Phase
HY-176785S MCB-294 / Phase 4
HY-148439 Daraxonrasib Inhibitor 99.88% Phase 3
HY-145928 Divarasib Inhibitor 99.31% Phase 3
HY-139612 Opnurasib Inhibitor 98.16% Phase 3
HY-132844 Tunlametinib Inhibitor 99.53% Phase 3
HY-156819 Zoldonrasib 99.73% Phase 2
HY-160699 DCC-3116 Inhibitor 99.25% Phase 2
HY-143589 Glecirasib Inhibitor 99.20% Phase 2
HY-114491 Rineterkib Inhibitor 99.83% Phase 2
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Phase 2
HY-N6674 Diazepinomicin 98.04% Phase 2
HY-134813 MRTX1133 Inhibitor 99.97% Phase 1
HY-15610 GDC-0623 98.74% Phase 1
HY-16111 BMS-214662 Inhibitor 99.86% Phase 1
HY-147245 Basroparib Inhibitor 98.64% Phase 1
HY-152848 Fulzerasib Inhibitor 99.60% Phase 1
HY-173629 RMC-5127 99.19% Phase 1
HY-16373 CP-609754 Inhibitor 99.21% Phase 1
Pre-clinical Phase
生物活性分子 (433)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153724 BI-2865 99.65% 否
HY-156498 RMC-7977 Inhibitor 99.48% 否
HY-147214 GNE-7883 Inhibitor 99.54% 否
HY-16909 Leptomycin B Inhibitor 99.94% 否
HY-125817 BI-3406 Inhibitor 99.95% 否
HY-153346 Elironrasib 99.65% 否
HY-126247 BI-2852 Inhibitor 99.57% 否
HY-158115 NST-628 Inhibitor 98.61% 否
HY-112929 DT-061 Activator 99.95% 否
HY-156002 LUNA18 Inhibitor 99.76% 否
HY-137516 LC-2 Inhibitor 98.48% 否
HY-114398 BAY-293 Inhibitor 98.97% 否
HY-157228 ACBI3 Degrader 99.47% 否
HY-135985 DCLK1-IN-1 99.35% 否
HY-148273 Setidegrasib Inhibitor 99.65% 否
HY-153723 BI-2493 Inhibitor 99.79% 否
HY-173632 AMG410 Inhibitor 98.50% 否
HY-15872A FTI-277 hydrochloride 98.29% 否
HY-158107 BBO-8520 Inhibitor 99.90% 否
HY-138188 KRA-533 Agonist 98.73% 否
HY-148098 Pan KRas-IN-1 Inhibitor 99.31% 否
HY-W095672A (2R,7aS)-2-Fluorotetrahydro-1H-pyrrolizine-7a(5H)-methanol 99.82% 否
HY-132980 Olomorasib Inhibitor 98.48% 否
HY-U00418 ARS-1620 Inhibitor 99.59% 否
HY-18303 AMG-47a Inhibitor 99.19% 否
HY-159127 HRS-4642 Inhibitor 98.06% 否
HY-19713 LJI308 Inhibitor 99.07% 否
HY-128350 FGTI-2734 Inhibitor 99.85% 否
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.57% 否
HY-114436 MRTX-1257 Inhibitor 99.71% 否
HY-161176 PROTAC KRAS G12D degrader 1 98.32% 否
HY-148409 MMRi62 99.59% 否
HY-129523 PROTAC K-Ras Degrader-1 Inhibitor 99.90% 否
HY-136265 BC-LI-0186 Inhibitor 99.20% 否
HY-15747 Deltarasin Inhibitor 99.12% 否
HY-159788 PROTAC K-Ras Degrader-4 Degrader 99.01% 否
HY-128574 D927 Activator 99.46% 否
HY-18707 K-Ras(G12C) inhibitor 12 99.57% 否
HY-156671 RMC-4998 99.31% 否
HY-159190 HRX-0233 Inhibitor 98.92% 否
HY-162809 XMU-MP-9 99.12% 否
HY-N0735 Phellodendrine chloride 99.79% 否
HY-19706 ARS-853 98.39% 否
HY-162431 Calderasib Inhibitor 99.82% 否
HY-173637 AZD0022 Inhibitor 98.36% 否
HY-122914 KRAS inhibitor-3 Inhibitor 99.87% 否
HY-128522 ARS-1323-alkyne Inhibitor 99.59% 否
HY-128350A FGTI-2734 mesylate Inhibitor 99.65% 否
HY-18674 K-Ras-IN-1 Inhibitor 98.00% 否
HY-137497 KRAS inhibitor-9 99.85% 否
HY-139186 PROTAC KRAS G12C degrader-1 Degrader 99.15% 否
HY-151523 KRas G12R inhibitor 1 Inhibitor 98.19% 否
HY-15879 LB42708 ≥99.0% 否
HY-40040 (S)-1-Boc-3-methylpiperazine 99.97% 否
HY-49385 E3 ligase Ligand 64 ≥98.0% 否
HY-138295 KRAS inhibitor-10 Inhibitor 99.92% 否
HY-U00416 ARS-1323 Inhibitor 99.67% 否
HY-141477 RM-018 Inhibitor 95.50% 否
HY-154959 AZD4747 Inhibitor 99.81% 否
HY-151881 SOS1-IN-15 Inhibitor 98.04% 否
HY-126247B (R)-BI-2852 Control 97.32% 否
HY-134654 MRTX849 analog 24 98.70% 否
HY-P2265A SAH-SOS1A TFA Inhibitor 96.79% 否
HY-160023 Elisrasib Inhibitor 98.50% 否
HY-132966 ASP2453 Inhibitor 98.28% 否
HY-144661 KRAS G12D inhibitor 14 99.39% 否
HY-147008 XP-524 Inhibitor 99.66% 否
HY-114277B Sotorasib isomer Control 99.09% 否
HY-139047 SW157765 Inhibitor 98.08% 否
HY-145737A PROTAC SOS1 degrader-1 TFA Agonist 99.38% 否
HY-W016889 CFL-137 Inhibitor 99.92% 否
HY-125872 KRAS G12C inhibitor 14 Inhibitor 99.00% 否
HY-114277S Sotorasib-d7 Inhibitor 98.90% 否
HY-136726 CGP-82996 Inhibitor 98.12% 否
HY-146243 TH-Z835 99.58% 否
HY-148278 BI-0474 Inhibitor 99.83% 否
HY-176134 RP03707 Degrader / 否
HY-P3277 KRpep-2d Inhibitor 95.09% 否
HY-16662 Oncrasin-1 98.16% 否
HY-145962A MRTX-EX185 formic Inhibitor 97.23% 否
HY-16967 MM41 98.89% 否
HY-125847 Salvianolic acid F 99.30% 否
HY-153821 PROTAC KRAS G12C degrader-2 Degrader 98.45% 否
HY-156529 pan-KRAS-IN-2 Inhibitor 98.01% 否
HY-161906 SD-066-4 Inhibitor 99.96% 否
HY-176523 KRAS G12D-IN-29 Inhibitor 97.02% 否
HY-164315 KRAS G12C inhibitor 67 Inhibitor 98.80% 否
HY-157029S KRASG12D-IN-1 Inhibitor 98.07% 否
HY-128590 PHT-7.3 Inhibitor 99.29% 否
HY-128771 K-Ras G12C-IN-4 Inhibitor 99.19% 否
HY-142160 GNE-9815 Inhibitor 98.94% 否
HY-151517 SOS1-IN-14 Inhibitor 99.60% 否
HY-115880A KRAS G12D inhibitor 3 TFA Inhibitor 98.18% 否
HY-159652 KRAS inhibitor-31 Inhibitor 99.36% 否
HY-161235 BTX-7312 98.35% 否
HY-162960 pan-KRAS degrader 1 Degrader 99.93% 否
HY-163299 pan-KRAS-IN-5 / 否
HY-163595 KRAS G12D-IN-31 Inhibitor 98.53% 否
HY-168054 PROTAC K-Ras Degrader-3 Degrader 98.08% 否
HY-41832 4,6-Dichloro-2-(methylthio)pyrimidine 98.51% 否
HY-P10436 Braftide Inhibitor 99.68% 否
HY-W998345 SMART1 Inhibitor 99.87% 否
HY-115489A GGTI-286 TFA Inhibitor / 否
HY-161233 BTX-6654 Inhibitor / 否
HY-170428 IPS-06061 Degrader / 否
HY-125873 KRAS G12C inhibitor 15 Inhibitor 98.47% 否
HY-130991 K-Ras ligand-Linker Conjugate 6 / 否
HY-107720 ARL 17477 Inhibitor 99.02% 否
HY-122641 Deltasonamide 1 Inhibitor 99.15% 否
HY-143599 KRAS G12D inhibitor 8 Inhibitor / 否
HY-145615 Pomalidomide-C12-NH2 hydrochloride 97.09% 否
HY-153663 TH-Z827 Inhibitor / 否
HY-156671A RMC-4998 formic 99.02% 否
HY-161066 KRAS G13D-IN-1 Inhibitor / 否
HY-161177 PROTAC KRAS G12D degrader 2 Inhibitor / 否
HY-173637A (S)-AZD0022 Inhibitor / 否
HY-N0427 Phellodendrine 99.60% 否
HY-15747A Deltarasin hydrochloride Inhibitor 98.07% 否
HY-16111A BMS-214662 hydrochloride Inhibitor / 否
HY-48187 KRAS inhibitor-39 / 否
HY-18604 K-Ras G12C-IN-1 Inhibitor 98.19% 否
HY-115489 GGTI-286 Inhibitor / 否
HY-134813A MRTX1133 formic Inhibitor 98.23% 否
HY-157031S KRASG12D-IN-2 Inhibitor 98.11% 否
HY-U00417 ARS-1630 Inhibitor 98.10% 否
HY-139894 KRAS G12D inhibitor 5 Inhibitor / 否
HY-142460 KRAS G12C inhibitor 28 Inhibitor 99.94% 否
HY-145962 MRTX-EX185 Inhibitor / 否
HY-163939 RGT-018 Inhibitor 99.77% 否
HY-18606 K-Ras G12C-IN-3 Inhibitor 99.94% 否
HY-130707 K-Ras ligand-Linker Conjugate 3 / 否
HY-130823 K-Ras ligand-Linker Conjugate 5 99.79% 否
HY-153262 (7R)-Elisrasib Inhibitor 99.52% 否
HY-104067 Naphthol AS-MX phosphate Inhibitor 99.50% 否
HY-112491 KRas G12C inhibitor 1 Inhibitor / 否
HY-112929B (1S,2S,3R)-DT-061 99.77% 否
HY-114398A (S)-BAY-293 / 否
HY-117935 GGTI-286 hydrochloride Inhibitor / 否
HY-123929 PAWI-2 99.29% 否
HY-130819 Tos-PEG4-THP 95.0% 否
HY-130820 THP-PEG4-Pyrrolidine(N-Boc)-CH2OH 95.0% 否
HY-130821 THP-PEG4-Pyrrolidine(N-Me)-CH2OH 95.0% 否
HY-134811 KRAS G12D inhibitor 1 Inhibitor / 否
HY-134977 Atrovastatin-PEG3-FITC Inhibitor 98.17% 否
HY-139402 MRTX849 acid Inhibitor 99.84% 否
HY-139612A (S)-JDQ-443 Inhibitor 99.32% 否
HY-143603 KRAS G12D inhibitor 10 Inhibitor / 否
HY-144657A (4S)-PROTAC SOS1 degrader-1 diTFA Inhibitor 98.09% 否
HY-153413 Kras4B G12D-IN-1 Inhibitor 98.01% 否
HY-154313 Spiclomazine Inhibitor 99.95% 否
HY-154959A (9R,12aR)-AZD4747 Control 98.90% 否
HY-159474 KRAS inhibitor-24 Inhibitor / 否
HY-164350 KRAS inhibitor-27 Inhibitor / 否
HY-164493 KRASG12C IN-13 Inhibitor 99.01% 否
HY-164749 K-Ras-IN-4 Inhibitor / 否
HY-168669 PROTAC K-Ras Degrader-5 Inhibitor / 否
HY-171255 KRAS G12D inhibitor 26 Inhibitor 98.39% 否
HY-176792 ACBI-4 Degrader / 否
HY-P3277A KRpep-2d TFA Inhibitor 98.11% 否
HY-12446 K-Ras(G12C) inhibitor 9 Inhibitor ≥98.0% 否
HY-145928B Divarasib adipate Inhibitor / 否
HY-15872 FTI-277 / 否
HY-18605 K-Ras G12C-IN-2 Inhibitor 99.21% 否
HY-RS07425 KRAS Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-135864 KRAS inhibitor-6 Inhibitor / 否
HY-135865 KRAS inhibitor-7 Inhibitor / 否
HY-135866 KRAS inhibitor-8 Inhibitor / 否
HY-115880 KRAS G12D inhibitor 3 Inhibitor / 否
HY-129775 K-Ras ligand-Linker Conjugate 1 / 否
HY-129776 K-Ras ligand-Linker Conjugate 2 / 否
HY-132920 KRAS mutant protein inhibitor 1 Inhibitor / 否
HY-142458 KRAS G12C inhibitor 27 Inhibitor / 否
HY-142487 KRAS G12C inhibitor 32 Inhibitor / 否
HY-108887 Anticancer agent 124 Inhibitor / 否
HY-125874 KRAS G12C inhibitor 16 Inhibitor / 否
HY-125875 KRAS G12C inhibitor 17 Inhibitor / 否
HY-126292 KRAS G12C inhibitor 13 Inhibitor / 否
HY-130260 KRAS inhibitor-4 Inhibitor / 否
HY-130822 K-Ras ligand-Linker Conjugate 4 98.76% 否
HY-132979 KRAS G12C inhibitor 18 Inhibitor / 否
HY-146544 KRAS inhibitor-14 Inhibitor / 否
HY-146546 KRAS inhibitor-16 Inhibitor / 否
HY-150926 G12Si-1 Inhibitor / 否
HY-150927 G12Si-2 Inhibitor / 否
HY-151287 KRAS inhibitor-20 Inhibitor / 否
HY-162249 ASP6918 Inhibitor / 否
HY-107841 K-Ras(G12C) inhibitor 6 Inhibitor 99.08% 否
HY-108436 Deltazinone 1 Inhibitor / 否
HY-114436S MRTX-1257-d6 / 否
HY-115907 K20 Inhibitor / 否
HY-115907A (rac)-K20 / 否
HY-117807 A-176120 Inhibitor / 否
HY-120763 LB42908 Inhibitor / 否
HY-122152 Spiclomazine hydrochloride Inhibitor / 否
HY-122641D Deltasonamide 1 TFA Inhibitor 99.70% 否
HY-124761 Poloppin Inhibitor / 否
HY-125335 Oligomycin D / 否
HY-126180 BAY-866 Inhibitor / 否
HY-130991A K-Ras ligand-Linker Conjugate 6 formate 98.93% 否
HY-13497 STK33-IN-1 Inhibitor / 否
HY-137516A LC-2 epimer / 否
HY-137971 (±)-Spiro-oxanthromicin A Inhibitor / 否
HY-139403 MRTX849 ethoxypropanoic acid Antagonist / 否
HY-139910 KRAS G12D inhibitor 6 Inhibitor / 否
HY-139911 KRAS G12D inhibitor 7 Inhibitor / 否
HY-142457 KRAS G12C inhibitor 26 Inhibitor / 否
HY-142478 KRAS G12C inhibitor 29 Inhibitor / 否
HY-142481 KRAS G12C inhibitor 30 Inhibitor / 否
HY-142485 KRAS G12C inhibitor 31 Inhibitor / 否
HY-142490 KRAS G12C inhibitor 33 Inhibitor / 否
HY-142511 KRAS G12C inhibitor 34 Inhibitor / 否
HY-142945 KRAS G12C inhibitor 43 Inhibitor / 否
HY-142946 KRAS G12C inhibitor 44 Inhibitor / 否
HY-142947 KRAS G12C inhibitor 45 Inhibitor / 否
HY-142948 KRAS G12C inhibitor 46 Inhibitor / 否
HY-143359 COTI-219 Inhibitor / 否
HY-143588 KRAS G12C inhibitor 35 Inhibitor / 否
HY-143590 KRAS G12C inhibitor 37 Inhibitor / 否
HY-143591 KRAS G12C inhibitor 38 Inhibitor / 否
HY-143592 KRAS G12C inhibitor 39 Inhibitor / 否
HY-143594 KRAS G12C inhibitor 40 Inhibitor / 否
HY-143596 KRAS G12C inhibitor 41 Inhibitor / 否
HY-143598 KRAS G12C inhibitor 42 Inhibitor / 否
HY-143602 KRAS G12D inhibitor 9 Inhibitor / 否
HY-143604 KRAS G12D inhibitor 11 Inhibitor / 否
HY-143606 KRAS G12D inhibitor 12 Inhibitor / 否
HY-143607 KRAS G12D inhibitor 13 Inhibitor / 否
HY-144207 SOS1-IN-9 Inhibitor / 否
HY-144210 SOS1-IN-6 Inhibitor / 否
HY-144211 SOS1-IN-7 Inhibitor / 否
HY-144213 SOS1-IN-10 Inhibitor / 否
HY-144323 YF135 Inhibitor / 否
HY-144657 (4S)-PROTAC SOS1 degrader-1 Inhibitor / 否
HY-145017 KRAS G12C inhibitor 20 Inhibitor / 否
HY-145018 KRAS G12C inhibitor 21 Inhibitor / 否
HY-145019 KRAS G12C inhibitor 22 Inhibitor / 否
HY-145020 KRAS G12C inhibitor 23 Inhibitor / 否
HY-145022 KRAS G12C inhibitor 25 Inhibitor / 否
HY-145047 SOS1-IN-4 Inhibitor / 否
HY-145048 SOS1-IN-5 Inhibitor / 否
HY-145436 KRAS inhibitor-11 Inhibitor / 否
HY-145737 PROTAC SOS1 degrader-1 Agonist / 否
HY-146061 KRAS G12C inhibitor 48 Inhibitor / 否
HY-146475 KRAS inhibitor-17 Inhibitor / 否
HY-146476 KRAS inhibitor-18 Inhibitor / 否
HY-146533 KRAS inhibitor-12 Inhibitor / 否
HY-146537 KRAS G12C inhibitor 47 Inhibitor / 否
HY-146543 KRAS inhibitor-13 Inhibitor / 否
HY-146545 KRAS inhibitor-15 Inhibitor / 否
HY-147595 KRAS G12D inhibitor 15 Inhibitor / 否
HY-147631 KRAS G12C inhibitor 50 Inhibitor / 否
HY-147632 KRAS G12C inhibitor 51 Inhibitor / 否
HY-147633 KRAS G12C inhibitor 52 Inhibitor / 否
HY-147634 KRAS G12C inhibitor 53 Inhibitor / 否
HY-147635 KRAS G12C inhibitor 54 Inhibitor / 否
HY-147636 KRAS G12C inhibitor 55 Inhibitor / 否
HY-148260 KRAS G12D inhibitor 16 Inhibitor / 否
HY-148261 KRAS G12C inhibitor 56 Inhibitor / 否
HY-149607 SHP2-IN-22 Inhibitor / 否
HY-149705 ICMT-IN-7 Inhibitor / 否
HY-149709 ICMT-IN-35 Inhibitor / 否
HY-151288 KRAS inhibitor-21 Inhibitor / 否
HY-15136B (Rac)-Lonafarnib / 否
HY-151571 ZG1077 Inhibitor / 否
HY-151968 KRAS G12C inhibitor 57 Inhibitor / 否
HY-151999 KRAS G12C inhibitor 65 Inhibitor / 否
HY-152145 PROTAC SOS1 degrader-3 / 否
HY-152248 ARS-2102 Inhibitor / 否
HY-153412 KRAS inhibitor-22 Degrader / 否
HY-153461 KRAS G12C inhibitor 58 Inhibitor / 否
HY-153555 KRAS G12D modulator-1 Modulator / 否
HY-153662 TH-Z816 Inhibitor / 否
HY-153880 KRAS degrader-1 Degrader / 否
HY-153881 KRAS G12C degrader-1 / 否
HY-153899 KRAS G12C inhibitor 59 Inhibitor / 否
HY-153940 SOS1/KRAS-IN-1 Inhibitor / 否
HY-153944 KRAS G12C inhibitor 60 Inhibitor / 否
HY-156363 K-Ras-IN-2 Inhibitor / 否
HY-156500 ICMT-IN-1 Inhibitor / 否
HY-156528 pan-KRAS-IN-4 Inhibitor / 否
HY-156549 KRAS G12C inhibitor 61 Inhibitor / 否
HY-156555 pan-KRAS-IN-3 / 否
HY-157458 PDEδ autophagic degrader 1 / 否
HY-158008 (R)-G12Di-7 Inhibitor / 否
HY-158701 KRAS G12D inhibitor 23 Inhibitor / 否
HY-158703 KRAS G12D inhibitor 24 Inhibitor / 否
HY-159163 KRASG12C IN-12 Inhibitor / 否
HY-159473 K-Ras-IN-3 Inhibitor / 否
HY-159475 KRAS inhibitor-25 Inhibitor / 否
HY-159476 KRAS inhibitor-26 Inhibitor / 否
HY-159611 KRAS G12C inhibitor 68 Inhibitor / 否
HY-160445 KRAS G12D inhibitor 19 Inhibitor / 否
HY-161173 PROTAC SOS1 degrader-5 / 否
HY-161234 KRAS ligand 3 Ligand / 否
HY-161236 KRAS ligand 4 Inhibitor / 否
HY-161450 LHF418 Inhibitor / 否
HY-161654 PROTAC SOS1 degrader-10 / 否
HY-161714 HH0043 Inhibitor / 否
HY-162281 PROTAC SOS1 degrader-6 / 否
HY-162321 ZINC57632462 Inhibitor / 否
HY-162366 KRAS G12D inhibitor 20 Inhibitor / 否
HY-162439 pan-KRAS-IN-6 Inhibitor / 否
HY-162440 pan-KRAS-IN-7 Inhibitor / 否
HY-162441 pan-KRAS-IN-8 Inhibitor / 否
HY-162442 pan-KRAS-IN-9 Inhibitor / 否
HY-162443 pan-KRAS-IN-10 Inhibitor / 否
HY-162444 KRAS G12D inhibitor 22 Inhibitor / 否
HY-162445 KRASG12D-IN-3 Inhibitor / 否
HY-162445S KRASG12D-IN-3-d3 / 否
HY-162446 pan-KRAS-IN-13 Inhibitor / 否
HY-162873 MEK/RAF-IN-1 Inhibitor / 否
HY-162971 KRAS inhibitor-33 Inhibitor / 否
HY-162974 KRAS inhibitor-34 Inhibitor / 否
HY-162976 KRAS inhibitor-35 Inhibitor / 否
HY-162983 KRAS inhibitor-36 Inhibitor / 否
HY-163488 KRASG12D-IN-4 Inhibitor / 否
HY-163489 pan-KRAS-IN-15 Inhibitor / 否
HY-163636 Deltaflexin3 Inhibitor / 否
HY-163720 KRAS G12C inhibitor 63 / 否
HY-163880 EGFR-IN-119 Inhibitor / 否
HY-164365 PROTAC K-Ras Degrader-2 Degrader / 否
HY-164492 LSN3074753 Inhibitor / 否
HY-164632 KRAS inhibitor-32 Inhibitor / 否
HY-164645 pan-KRAS-IN-16 Inhibitor / 否
HY-168012 Pan-RAS-IN-6 Inhibitor / 否
HY-168013 KRASG12C IN-14 Inhibitor / 否
HY-168055 (S)-Deoxy-thalidomide / 否
HY-168076 (S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc / 否
HY-168442 KRAS inhibitor-40 Inhibitor / 否
HY-168512 BRAFV600E-IN-1 Inhibitor / 否
HY-168514 SOS1/EGFR-IN-2 Inhibitor / 否
HY-168577 KRAS G12D inhibitor 25 / 否
HY-168637 SIAIS562055 Inhibitor / 否
HY-168672 E3 Ligase Ligand-linker Conjugate 133 / 否
HY-168678 PROTAC K-Ras Degrader-6 Inhibitor / 否
HY-168700 KRAS G12D ligand-2 / 否
HY-168847 INCB159020 Inhibitor / 否
HY-168919 KRASG12C IN-16 / 否
HY-169311 KRAS inhibitor-37 Inhibitor / 否
HY-169312 KRAS inhibitor-38 Inhibitor / 否
HY-170550 KRAS G12C inhibitor 69 Inhibitor / 否
HY-170785 pan-KRAS-IN-17 Inhibitor / 否
HY-172221 SOS1-IN-18 Inhibitor / 否
HY-172237 Sosimerasib Inhibitor / 否
HY-172626 KRAS G12D inhibitor 28 Inhibitor / 否
HY-172919 PDEδ/NAMPT IN-1 / 否
HY-173047 KRASG12C IN-15 Inhibitor / 否
HY-173250 YN14-H / 否
HY-173252 KRASG12C ligand-1 Inhibitor / 否
HY-173329 KRAS-IN-41 Inhibitor / 否
HY-173341 SOF-436 Inhibitor / 否
HY-174243 KRASG12D-IN-5 Inhibitor / 否
HY-174254 AKT-IN-28 / 否
HY-174261 KRAS-IN-5 Inhibitor / 否
HY-174379 KRAS IN-44 / 否
HY-174851 KRAS G12C-IN-70 Inhibitor / 否
HY-175025 CH091138 / 否
HY-175144 KRASG12D-IN-6 Inhibitor / 否
HY-175244 SOS1-IN-20 Inhibitor / 否
HY-175265 PQ32 / 否
HY-175326 SOS1-IN-21 Inhibitor / 否
HY-175419 TBIA Inhibitor / 否
HY-175529 KRASG12D-IN-7 / 否
HY-175560 SOS1-IN-22 Inhibitor / 否
HY-175673 LCB-2151 / 否
HY-175806 CS47 / 否
HY-175860 KRAS G12D ligand-Linker Conjugate 2 / 否
HY-175870 pan-KRAS-IN-18 Inhibitor / 否
HY-176170 SOS1-IN-19 Inhibitor / 否
HY-176250 KRAS-IN-43 Inhibitor / 否
HY-176341S KRAS 2B G13D mutant, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-176342S KRAS 2B Q61H mutant, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-176353S KRAS 2B G13C mutant, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-176354S KRAS 2B G12V mutant, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-176355S KRAS 2A, U-15N / 否
HY-176356S KRAS 2B, Arg-13C6,15N4, Lys-13C6,15N4 / 否
HY-176357S KRAS 2B G12R mutant, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-176358S KRAS 2B G12C mutant, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-176359S KRAS 2B G12D mutant, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-176419 KRAS inhibitor-42 Inhibitor / 否
HY-176489 PROTAC pan-KRAS degrader-1 / 否
HY-176490 pan-KRAS ligand 3 / 否
HY-176491 Alkyne-pyrazine-O-piperidine-(1-methylcyclopropyl)methanol Chemical / 否
HY-176492 E3 Ligase Ligand-linker Conjugate 193 Chemical / 否
HY-176786 MCB-36 / 否
HY-176787 KRAS G12C Ligand-Linker Conjugates 1 Inhibitor / 否
HY-176870 KRAS-IN-42 Inhibitor / 否
HY-177511 KRAS G12D-IN-30 Inhibitor / 否
HY-178042 SS-3091 Inhibitor / 否
HY-178044 SOS1-IN-24 Inhibitor / 否
HY-178194 SHY-855 Inhibitor / 否
HY-178211 SHY-867 Inhibitor / 否
HY-178224 Morindone / 否
HY-18652A Avutometinib potassium Inhibitor / 否
HY-N8387 Neogrifolin Inhibitor / 否
HY-P10847 KS-58 Inhibitor / 否
HY-P11294 KLVVVGADGVGKSALTI / 否
HY-P11356 KRAS G12V Peptide Activator / 否
HY-P11357 KRAS G12C Peptide Activator / 否
HY-P11357A KRAS G12C Peptide TFA Activator / 否
HY-P2265 SAH-SOS1A Inhibitor / 否
HY-P3129 KRAS G13D peptide, 25 mer / 否
HY-P3430 JM3A / 否
HY-P5192 KRAS G12D(8-16) / 否
HY-RS07426 Kras Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07427 Kras Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09558 NRAS Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W041315 CFL-120 Inhibitor ≥98.0% 否
HY-W556631 LZTR1-KRAS modulator 1 Activator / 否
HY-110038 FTI-277 TFA / 否
HY-112541 21-Hydroxyoligomycin A Inhibitor / 否
HY-114277S2 Sotorasib-d3 Inhibitor / 否
HY-120885 (+)-Oxanthromicin Modulator / 否
HY-121459 Neoantimycin Modulator / 否
HY-149710 POP-3MB Inhibitor / 否
HY-157067 KRAS G12C inhibitor 62 Inhibitor / 否
HY-160220S KRAS inhibitor-23 Inhibitor / 否
HY-161655 SOS1 Ligand intermediate-5 Inhibitor / 否
HY-161656 PIP-C-3-Azaspiro[5.5]undecane-boc / 否
HY-164389 SML-10-70-1 / 否
HY-164427 SHP2-IN-31 Inhibitor / 否
HY-164513 NHTD Inhibitor / 否
HY-164529 SJ-C1044 Inhibitor / 否
HY-168056 KRAS ligand 5 / 否
HY-168075 Boc-PIP-Me-CH2-2,7-diazaspiro[3.5]nonane / 否
HY-168671 pan-KRAS ligand 1 Inhibitor / 否
HY-168680 E3 Ligase Ligand-linker Conjugate 135 / 否
HY-42936 ARS-1620 intermediate / 否
HY-W335254 Deltarasin trihydrochloride Inhibitor / 否
HY-114168 KRAS G12C inhibitor 5 Inhibitor / 否
HY-112492 KRas G12C inhibitor 2 Inhibitor / 否
HY-112493 KRas G12C inhibitor 3 Inhibitor / 否
HY-112494 KRas G12C inhibitor 4 Inhibitor / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991571 GC1118 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kras NCBI NCBI:3845
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