2. GPCR/G Protein MAPK/ERK Pathway PI3K/Akt/mTOR Apoptosis NF-κB Metabolic Enzyme/Protease
  3. Ras PI3K Akt Caspase Apoptosis Bcl-2 Family NF-κB MMP
  4. Salvianolic acid F

Salvianolic acid F  (Synonyms: 丹酚酸 F)

目录号: HY-125847 纯度: 99.72%
COA 产品使用指南 技术支持

Salvianolic acid F 是 KRAS 抑制剂，尤其针对 KRAS G12D。Salvianolic acid F 可同时抑制 NF-κB、MMP-9 和NO。Salvianolic acid F 在体外通过 EP300/PI3K/AKT 通路抑制癌细胞生长、侵袭和迁移，并诱导细胞凋亡 (apoptosis)。Salvianolic acid F 在体内通过 PI3K/AKT 信号通路抑制 KRAS 依赖性肺癌细胞的生长。Salvianolic acid F 可用于多种癌症的研究，包括 KRAS G12D 驱动的非小细胞肺癌 (NSCLC) 和卵巢癌。

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Salvianolic acid F

Salvianolic acid F Chemical Structure

CAS No. : 158732-59-3

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Salvianolic acid F 相关抗体

Top Publications Citing Use of Products

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K-Ras H-Ras N-Ras Ras

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Salvianolic acid F is a KRAS inhibitor, especially for KRAS G12D. Salvianolic acid F inhibits NF-kB, MMP-9, and NO simultaneously. Salvianolic acid F inhibits cancer cell growth, invasion, and migration and induces apoptosis via the EP300/PI3K/AKT pathway in vitro. Salvianolic acid F inhibits the growth of KRAS-dependent lung cancer cells via the PI3K/AKT signaling pathway in vivo. Salvianolic acid F can be used in the research of various cancers, including KRAS G12D-driven non-small cell lung cancer (NSCLC) and ovarian cancer[1][2].

IC50 & Target[1][2]

K-RAS

 

Caspase 3

 

MMP-9

 

体外研究
(In Vitro)

Salvianolic acid F (0-100 μM, 24-72 h) 对 A549 和 OE-KRAS A549 细胞有细胞毒性，24 h IC50 分别为 41.18 和 36.55 μM，48 h IC50 分别为 35.17 和 29.33 μM，对 OVCAR-3 和 SK-OV-3 OC 细胞有细胞毒性，IC50 分别为 28.89 和 29.94 μM[1][2]。
Salvianolic acid F (0-40 μM, 48 h) 可抑制 OE-KRAS A549、OVCAR-3 和 SK-OV-3 OC 细胞的迁移和增殖，并促进其凋亡[1][2]。
Salvianolic acid F (0-40 μM，48小时) 可抑制 OVCAR-3、SK-OV-3 OC 细胞中的 EP300/PI3K/AKT 信号通路[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Salvianolic acid F 相关抗体:

Cell Migration Assay [1]

Cell Line: OE-Ctrl, OE-KRAS, shCtrl, and shKRAS A549 cells
Concentration: 0, 10, 20 µM
Incubation Time: 48 h
Result: Inhibited the in vitro migration of OE-KRAS A549 cells, but had a poorer inhibition on the migration of shKRAS A549 cells at 20 µM.

Apoptosis Analysis[1]

Cell Line: OE-KRAS and shKRAS A549 cells
Concentration: 0, 10, 20 µM
Incubation Time: 48 h
Result: Induced marked apoptosis in OE-KRAS A549 cells, but showed not obvious apoptosis in shKRAS A549 cells.

Immunofluorescence[2]

Cell Line: OVCAR-3, SK-OV-3 OC cells
Concentration: 0, 20, 40 µM
Incubation Time: 48 h
Result: Significant reduced EdU-positive cells.

Cell Migration Assay [2]

Cell Line: OVCAR-3, SK-OV-3 OC cells
Concentration: 0, 20, 40 µM
Incubation Time: 48 h
Result: Inhibited cell migration.

Apoptosis Analysis[2]

Cell Line: OVCAR-3, SK-OV-3 OC cells
Concentration: 0, 20, 40 µM
Incubation Time: 48 h
Result: Exhibited a significantly elevated apoptosis rate in a dose-dependent manner compared to untreated cells.
Increased caspase-3 cleavage, Bax expression, decreased Bcl-2 expression in a dose-dependent manner compared to control cells.

Western Blot Analysis[2]

Cell Line: OVCAR-3, SK-OV-3 OC cells
Concentration: 0, 20, 40 µM
Incubation Time: 48 h
Result: Decreased EP300, p-PI3K/PI3K, Bax/Bcl-2, and cleaved caspase-3/caspase-3 ratios.
体内研究
(In Vivo)

Salvianolic acid F (10-20 mg/kg，腹腔注射，每日一次，共 15 天) 可通过影响 A549 异种移植裸鼠模型中的下游 PI3K/AKT 通路有效抑制 KRAS 驱动的肺癌生长[1]。
Salvianolic acid F (10-20 mg/kg，腹腔注射，每 2 天一次，共 40 天) 可通过影响 KrasG12D 小鼠模型中的下游 PI3K/AKT 通路抑制肺癌生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 (5 × 106) xenografts nude mice (6 weeks old BALB/c) model[1]
Dosage: 10, 20 mg/kg
Administration: i.p., each day for 15 days
Result: Did not induce significant weight loss and began to inhibit tumor growth from day 7 at 20 mg/kg, with no significant inhibitory effect at 10 mg/kg.
Inhibited the expression of KRAS and reduced cell proliferation in mice at 20 mg/kg.
Inhibited AKT phosphorylation, increased the expression of Bax, cleaved-Caspase3 and cleaved-PARP, decreased the expression of Bcl2, promoted apoptosis in lung cancer cells.
Animal Model: KrasG12D mice model[1]
Dosage: 10, 20 mg/kg
Administration: i.p., every 2 days for 40 days
Result: Not changed body weight, decreased the number and size of lung tumors, reaching 48% and 64% in the 10 mg/kg and 20 mg/kg groups, compared with the control group.
Inhibited KrasG12D expression, inhibited the pathological histomorphology, reduced cell proliferation.
Inhibited AKT phosphorylation, increased the expression of Bax, cleaved-Caspase3 and cleaved-PARP, decreased the expression of Bcl2, promoted apoptosis in lung cancer cells.
分子量

314.29

Formula

C17H14O6
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

丹酚酸 F
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (318.18 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1818 mL 15.9089 mL 31.8177 mL
5 mM 0.6364 mL 3.1818 mL 6.3635 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.72%

COA (288 KB) HNMR (115 KB) CNMR (178 KB) RP-HPLC (197 KB) MS (134 KB)

产品使用指南 (1538 KB)
参考文献

Salvianolic acid F 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1818 mL 15.9089 mL 31.8177 mL 79.5444 mL
5 mM 0.6364 mL 3.1818 mL 6.3635 mL 15.9089 mL
10 mM 0.3182 mL 1.5909 mL 3.1818 mL 7.9544 mL
15 mM 0.2121 mL 1.0606 mL 2.1212 mL 5.3030 mL
20 mM 0.1591 mL 0.7954 mL 1.5909 mL 3.9772 mL
25 mM 0.1273 mL 0.6364 mL 1.2727 mL 3.1818 mL
30 mM 0.1061 mL 0.5303 mL 1.0606 mL 2.6515 mL
40 mM 0.0795 mL 0.3977 mL 0.7954 mL 1.9886 mL
50 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.5909 mL
60 mM 0.0530 mL 0.2651 mL 0.5303 mL 1.3257 mL
80 mM 0.0398 mL 0.1989 mL 0.3977 mL 0.9943 mL
100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7954 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Salvianolic acid F158732-59-3丹酚酸 FRasPI3KAktCaspaseApoptosisBcl-2 FamilyNF-κBMMPPhosphoinositide 3-kinasePKBProtein kinase BNuclear factor-κBNuclear factor-kappaBMatrix metalloproteinasesInhibitorapoptosisA549 cellsOVCAR-3 cellsSK-OV-3 OC cellsKrasG12D mice modellung cancerovarian cancerinhibitorinhibit

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