Hdac1 - histone deacetylase 1 Gene

中文名称：组蛋白脱乙酰酶 1

种属: Mus musculus

同用名: HD1; RPD3; MommeD5; Hdac1-ps

关于 Hdac1

功能概要

该基因编码的蛋白可启动多项功能，包括电子邮箱绑定活动； Krueppel 相关框域绑定活动；和启动子特异性染色质结合活性。参与多个过程，包括动物器官发育；组蛋白去乙酰化；和基因表达的调控。作用于多个过程的上游或内部，包括信号转导的负调节； RNA 聚合酶 II 对转录的负调控；和神经系统发育。位于异染色质；神经细胞体；和核。 NuRD 复合体和转录抑制复合体的一部分。以多种结构表达，包括大脑；早孕;胚胎间充质；泌尿生殖系统；和感觉器官。与人类 HDAC1（组蛋白脱乙酰酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including E-box binding activity; Krueppel-associated box domain binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of signal transduction; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in heterochromatin; neuronal cell body; and nucleus. Part of NuRD complex and transcription repressor complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Apr 2022]