2. Stem Cell/Wnt Apoptosis
  3. Wnt Apoptosis
  4. WNTinib

WNTinib  (Synonyms: APS-8-100-2)

目录号: HY-160765
产品使用指南

摩尔计算器

WNTinib (APS-8-100-2) 是一种多激酶 (multi-kinase) 抑制剂，选择性地拮抗 β-catenin (CTNNB1) 突变的肝细胞癌 (HCC)。WNTinib 通过抑制 KIT/MAPK 和下游 EZH2 激活来下调致癌 Wnt 信号传导。

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WNTinib Chemical Structure

WNTinib Chemical Structure

CAS No. : 2770091-44-4

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WNTinib 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation[1].

体外研究
(In Vitro)

WNTinib (1μM; 3 days) 在 CTNNB1 突变模型中诱导细胞凋亡[1]。
WNTinib (0-30 μM; 1 h) 抑制 HEPG2 细胞中的 pEZH2 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WNTinib 相关抗体:

Western Blot Analysis[1]

Cell Line: HEPG2 cells
Concentration: 0.5 μM
Incubation Time: 24 h
Result: inhibited the levels of pT367.
体内研究
(In Vivo)

WNTinib (20mg/kg；口服；0-24 h) 的半衰期为 9.38 小时，口服给药后24小时血浆浓度为 7 μM 并且给药后 72 小时血浆中可检测到的药物量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mice[1]
Dosage: 20mg/kg
Administration: Tail vein injection; 5 days
Result: inhibited tumors
分子量

498.38

Formula

C22H16F6N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WNTinib 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WNTinib2770091-44-4APS-8-100-2WntApoptosisHEPG2 cellsmulti-kinase inhibitormiceInhibitorinhibitorinhibit

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