1. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  2. Histamine Receptor
  3. Ebastine

Ebastine  (Synonyms: 依巴斯汀; LAS-W 090; RP64305)

目录号: HY-B0674 纯度: 99.67%
COA 产品使用指南

Ebastine (LAS-W 090) 是一种具有口服活性的第二代组胺 H1 受体 (histamine H1 receptor) 拮抗剂。Ebastine 可用于过敏性鼻炎的症状和慢性特发性荨麻疹的研究。

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Ebastine Chemical Structure

Ebastine Chemical Structure

CAS No. : 90729-43-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥605
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500 mg ¥550
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1 g ¥700
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5 g ¥2000
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Other Forms of Ebastine:

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MCE 顾客使用本产品发表的 2 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1].

IC50 & Target[1]

H1 Receptor

 

体外研究
(In Vitro)

Ebastine (10-500 ng/mL; 24-48 hours) treatment significantly increases the proliferation of HFDPC[2].
Ebastine (10-500 ng/mL; 24-48 hours) treatment shows dose-dependent increases in Cyclin D1, Cyclin E1, and Cyclin A expression levels. And the expression levels of Cdk4, Cdk2, and Cdc2 are alos increased. Ebastine treatment elevates expression levels of phospho-AKT and phospho-p44/42 extracellular signal-regulated kinase[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human follicle dermal papilla cells (HFDPC)
Concentration: 10 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL, 500 ng/mL
Incubation Time: 24 hours, 48 hours
Result: The proliferative activity in cells was significantly enhanced.

Western Blot Analysis[2]

Cell Line: Human follicle dermal papilla cells (HFDPC)
Concentration: 10 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL, 500 ng/mL
Incubation Time: 24 hours
Result: The expression levels of cell-cycle regulatory proteins and an antiapoptotic protein were increased in HFDPC.
体内研究
(In Vivo)

In rats, after intravenous administration of [14C]Ebastine at 2 mg/kg, the plasma level of radioactivity decreased biphasically with α-phase half-life (t1/2 α) of 1.6 h and β-phase half-life (t1/2 β) of 3.1 h[3].
Following oral administration of [14C]Ebastine at a dose of 2 mg/kg, the plasma level reached the maximum (Cmax) of 102 ng eq./ml at 2 h and decreased monophasically with t1/2 of 3.9 h. At 20 mg/kg, a monophasic decrease is also observed with Cmax of 1110 ng eq./ml at 4 h and with t1/2 of 4.0 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

469.66

Formula

C32H39NO2

CAS 号
性状

固体

颜色

White to off-white

中文名称

依巴斯汀;艾巴斯啶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 58.75 mg/mL (125.09 mM; 超声助溶)

DMSO 中的溶解度 : 8.33 mg/mL (17.74 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1292 mL 10.6460 mL 21.2920 mL
5 mM 0.4258 mL 2.1292 mL 4.2584 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.1292 mL 10.6460 mL 21.2920 mL 53.2300 mL
5 mM 0.4258 mL 2.1292 mL 4.2584 mL 10.6460 mL
10 mM 0.2129 mL 1.0646 mL 2.1292 mL 5.3230 mL
15 mM 0.1419 mL 0.7097 mL 1.4195 mL 3.5487 mL
Ethanol 20 mM 0.1065 mL 0.5323 mL 1.0646 mL 2.6615 mL
25 mM 0.0852 mL 0.4258 mL 0.8517 mL 2.1292 mL
30 mM 0.0710 mL 0.3549 mL 0.7097 mL 1.7743 mL
40 mM 0.0532 mL 0.2661 mL 0.5323 mL 1.3307 mL
50 mM 0.0426 mL 0.2129 mL 0.4258 mL 1.0646 mL
60 mM 0.0355 mL 0.1774 mL 0.3549 mL 0.8872 mL
80 mM 0.0266 mL 0.1331 mL 0.2661 mL 0.6654 mL
100 mM 0.0213 mL 0.1065 mL 0.2129 mL 0.5323 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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