H-9 Dihydrochloride 

H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines^[1][2][3].

H-9 Dihydrochloride significantly inhibits A431 cells^[1].
H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

324.23

C₁₁H₁₅Cl₂N₃O₂S

116700-36-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10(3):211-6.  [Content Brief]

  [2]. Vázquez-López A, et al. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005 May;30(5):613-8.  [Content Brief]

  [3]. Wollina U, et al. Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med. 2003 Oct;12(4):673-7.  [Content Brief]