1. PI3K/Akt/mTOR
  2. PI3K
  3. MSC2360844

MSC2360844 

目录号: HY-135827
产品使用指南

MSC2360844 是一种有效的口服活性选择性 PI3Kδ 抑制剂,IC50为 145 nM。MSC2360844 对一组 278 种其他激酶显示出高度选择性。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

MSC2360844 Chemical Structure

MSC2360844 Chemical Structure

CAS No. : 1305267-37-1

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

MSC2360844 is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. MSC2360844 shows highly selective against a panel of 278 additional kinases[1].

IC50 & Target

PI3Kδ

145 nM (IC50)

In Vitro

MSC2360844 (0-10 μM; 1 hours) completely abolished BCR-induced pAkt in Ramos B cells in a concentration-dependent manner with IC50 values of 280 nM[1].
MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48 nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells[1].

Cell Proliferation Assay[1]

Cell Line: B cells
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Inhibited B cell proliferation in a concentration-dependent manner with an IC50 of 48 nM.
In Vivo

MSC2360844 (6.6-66 mg/kg; daily from week 2 to 10) ameliorates disease manifestations in a murine SLE model[1].

Animal Model: NZB/W F1 female mice[1]
Dosage: 6.6, 22, or 66 mg/kg
Administration: Oral; starting at week 2 post ADV-IFNα delivery, once daily at 10 weeks
Result: Significantly reduced proteinuria incidence and severity in a dose-dependent manner.
Molecular Weight

526.58

Formula

C₂₆H₂₇FN₄O₅S

CAS No.

1305267-37-1

SMILES

O=C(C1=NN(C2=CC=C(CN3CCOCC3)C=C2)C(C4=CC=CC(F)=C45)=C1CS5(=O)=O)N6CCOCC6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MSC2360844MSC 2360844MSC-2360844PI3KPhosphoinositide 3-kinaseBcellsSLE-pronefunctionsproliferationprimaryInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
MSC2360844
目录号:
HY-135827
需求量: