1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. mAChR
    Calcium Channel
  3. Propiverine hydrochloride

Propiverine hydrochloride 

目录号: HY-116408A
产品使用指南

Propiverine hydrochloride 是具有钙拮抗和抗胆碱能特性的膀胱痉挛剂。Propiverine hydrochloride 可用于研究膀胱过度活动和尿失禁。

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Propiverine hydrochloride Chemical Structure

Propiverine hydrochloride Chemical Structure

CAS No. : 54556-98-8

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Description

Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2].

In Vitro

Propiverine (10-3000 nM) inhibits the specific binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively[2].

In Vivo

Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats[1].
Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo[1].

Animal Model: Female adult Sprague-Dawley rats (250-270 g)[1]
Dosage: 5 mg dissolved in distilled water (0.5 mL)
Administration: P.o. once daily for 2 weeks
Result: Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly.
Increased plasma epinephrine and norepinephrine levels.
No significant changes were observed in body weight.
Molecular Weight

403.94

Formula

C₂₃H₃₀ClNO₃

CAS No.

54556-98-8

中文名称

盐酸丙哌维林

SMILES

O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)OCCC)OC3CCN(CC3)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

PropiverinemAChRCalcium ChannelMuscarinic acetylcholine receptorCa2+ channelsCa channelsbladderspasmolyticcalciumanticholinergicantimuscarinicoveractiveblaqdderurinaryincontinenceInhibitorinhibitorinhibit

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产品名称:
Propiverine hydrochloride
目录号:
HY-116408A
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