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Pathways Recommended:	MAPK/ERK Pathway

Results for "

MAPK Kinase Kinase Kinase

" in MCE Product Catalog:

By Targets:	MAP4K (2) MAPKAPK2 (MK2) (4) p38 MAPK (48) AAK1 (3) Akt (6) AMPK (2) Apoptosis (14) Aurora Kinase (1) Autophagy (9) Bcr-Abl (1) Btk (1) c-Myc (1) CaMK (1) Casein Kinase (3) CDK (6) Checkpoint Kinase (Chk) (1) COX (2) Cyclin G-associated Kinase (GAK) (2) Drug Metabolite (1) DYRK (1) EGFR (3) Endogenous Metabolite (1) Ephrin Receptor (1) ERK (15) Ferroptosis (3) FGFR (3) FLT3 (2) HSP (1) IKK (1) Interleukin Related (2) IRAK (1) Isotope-Labeled Compounds (1) Itk (2) JAK (2) JNK (3) Keap1-Nrf2 (1) LIM Kinase (LIMK) (3) MAP3K (1) MEK (2) MELK (1) MMP (1) NF-κB (12) PDGFR (1) Phosphatase (1) Phosphodiesterase (PDE) (2) PI3K (5) Pim (1) PKC (1) PROTACs (7) Raf (7) RANKL/RANK (1) Ras (1) Reference Standards (5) RET (1) Salt-inducible Kinase (SIK) (3) Ser/Thr Kinase (1) SHP2 (1) Src (6) STAT (2) TAM Receptor (2) TGF-beta/Smad (2) TNF Receptor (2) Toll-like Receptor (TLR) (1) ULK (3) VEGFR (1) Wee1 (2) Wnt (4) β-catenin (1)
By Research Areas:	Cancer (50) Cardiovascular Disease (7) Endocrinology (2) Infection (3) Inflammation/Immunology (33) Metabolic Disease (6) Neurological Disease (7)
Oligonucleotides:	磷脂 (1)

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Targets Recommended: p38 MAPK MAP4K MNK MAPKAPK2 (MK2)

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-112401

p38 MAP Kinase Inhibitor IV	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor IV 是一种高度特异的 ATP 竞争性 p38α MAPK 抑制剂，p38 MAP Kinase Inhibitor IV 对 p38α 和 p38β MAPK 的 IC₅₀ 分别为 0.13 和 0.55 μM。

HY-112389

p38 MAP Kinase Inhibitor III 2 篇文献验证	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor III (compound 7h) 是一种 p38 MAPK 抑制剂，₅₀ 为 0.9 μM。p38 MAP Kinase Inhibitor III 也抑制 IL-1β 和 TNF-α 的释放，₅₀ 值分别为 0.37 μM 和 0.044 μM。

HY-49073

p38 MAP Kinase Inhibitor Ⅵ	p38 MAPK	Cancer
p38 MAP Kinase Inhibitor Ⅵ (compound c32) 是 p38 MAPK 抑制剂，抑制率达到 24%。

HY-120595

JNJ-49095397 RV568	p38 MAPK Src	Inflammation/Immunology
JNJ-49095397 (RV568) 是一种吸入性窄谱激酶抑制剂 (NSKI)，可抑制 p38 MAPK的 α 和 γ 亚型。JNJ-49095397 还抑制 SRC kinase 家族，特别是造血激酶(HCK)，显示出强大的抗炎作用，可用于慢性阻塞性肺疾病 (COPD) 和哮喘的研究。

HY-160765

WNTinib APS-8-100-2	Wnt Apoptosis	Cancer
WNTinib (APS-8-100-2) 是一种多激酶 (multi-kinase) 抑制剂，选择性地拮抗 β-catenin (CTNNB1) 突变的肝细胞癌 (HCC)。WNTinib 通过抑制 KIT/MAPK 和下游 EZH2 激活来下调致癌 Wnt 信号传导。

HY-142452

Pan-RAF kinase inhibitor 1	Raf	Cancer
Pan-RAF kinase inhibitor 1 (compound 16B) 是一种有效的 Pan-RAF 激酶抑制剂。Pan-RAF kinase inhibitor 1 通过抑制 RAF 激酶来调节 MAPK 信号传导，从而对 RAS 突变肿瘤细胞的增殖产生影响。 Pan-RAF kinase inhibitor 1 具有研究癌症疾病的潜力 (信息提取自专利 WO2021110141A1, 化合物 16B)。

HY-U00324

p38 MAPK-IN-2	p38 MAPK Autophagy	Cancer
p38 MAPK-IN-2 是一种 p38 kinase 的抑制剂。

HY-P10367

Ziptide	MAPKAPK2 (MK2) Checkpoint Kinase (Chk) AMPK	Others
Ziptide 是多种激酶的底物，如 MAPK蛋白激酶 2 (MAPKAPK2, K_m = 5 μM)、MAPKAPK3 (K_m = 30 μM)、PARK (K_m = 40 μM)、checkpoint kinase 1 (Chk1, K_m = 5 μM), AMP激活蛋白激酶 (AMPK, K_m = 75 μM) 以及钙/钙调素依赖性蛋白激酶 II (CamKII, K_m = 300 μM)。

HY-175429

p38 MAPK-IN-7	p38 MAPK	Inflammation/Immunology
p38 MAPK-IN-7 (Compound 2) 是一种具有口服活性并有效的 p38 丝裂原活化蛋白激酶 (p38 MAP kinase) 抑制剂 (IC₅₀=170 nM)。p38 MAPK-IN-10 有望用于炎症性疾病的研究，如类风湿性关节炎和脓毒症休克。

HY-175433

p38 MAPK-IN-10	p38 MAPK	Inflammation/Immunology
p38 MAPK-IN-10 (Compound 4) 是一种具有口服活性并有效的 p38 丝裂原活化蛋白激酶 (p38 MAP kinase) 抑制剂 (IC₅₀=570 nM)。p38 MAPK-IN-10 有望用于慢性炎症性疾病的研究，如类风湿性关节炎和克罗恩病。

HY-P10072A

MK2-IN-5 acetate Hsp25 Kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate 是 Mk2 的假底物 (K_i= 8 μM)。MK2-IN-5 acetate 靶向 MAPK 通路中的蛋白相互作用域。MK2-IN-5 acetate 抑制 HSP25 和 HSP27 的磷酸化。

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Neurological Disease Inflammation/Immunology
3-脱氧苏木酮 B Deoxysappanone B (3-Deoxysappanone B) 是一种从 Caesalpinia sappan L (Lignum Sappan) 分离得到的异黄酮化合物。Deoxysappanone B 具有抗神经炎症和神经保护作用，可以通过阻断 IκB kinase (IKK)-NF-κB 和 p38/ERK MAPK 途径的信号通路，抑制神经炎症介质的产生。Deoxysappanone B 可用于神经炎和炎症相关的神经损伤的疾病研究。

HY-N0031

Plantamajoside 2 篇文献验证	NF-κB PI3K Akt Apoptosis Autophagy p38 MAPK Src	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
车前子甙 Plantamajoside 是一种具有口服活性的苯丙烷类糖苷。Plantamajoside 可从车前 Plantago asiatica L. 中分离出来。Plantamajoside 失活 NF-κB, PI3K/akt, 诱导凋亡 (Apoptosis), 改善自噬 (Autophagy)。Plantamajoside 调节 *MAPK, integrin-linked kinase/c-Src*。Plantamajoside 抑制多种癌症，改善肺、肾损伤。Plantamajoside 具有神经保护和抗炎作用。

HY-N0031R

Plantamajoside (Standard)	Reference Standards NF-κB PI3K Apoptosis Autophagy p38 MAPK Src	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
车前子甙 (Standard) Plantamajoside (Standard) 是 Plantamajoside 的分析标准品。本产品用于研究及分析应用。Plantamajoside 是一种具有口服活性的苯丙烷类糖苷。Plantamajoside 可从车前 Plantago asiatica L. 中分离出来。Plantamajoside 失活 NF-κB, PI3K/akt, 诱导凋亡 (Apoptosis), 改善自噬 (Autophagy)。Plantamajoside 调节 *MAPK, integrin-linked kinase/c-Src*。Plantamajoside 抑制多种癌症，改善肺、肾损伤。Plantamajoside 具有神经保护和抗炎作用。

HY-107620

PD 198306	MEK	Neurological Disease
PD 198306 是一种选择性 MAPK/ERK 激酶 (MEK) 抑制剂。PD 198306 显著降低 Streptozocin 诱导的 ERK1/2 水平升高。具有抗痛觉过敏作用。

HY-15496

E6201 ER-806201	MEK FLT3	Cancer
E6201 (ER-806201) 是一种 ATP 竞争性的 MEK1 和 FLT3 双重激酶抑制剂。E6201 抑制 MEK1 诱导的 ERK2 磷酸化，IC₅₀ 值为 5.2 nM，MKK4 诱导的 JNK 磷酸化，IC₅₀ 值为 91 nM，以及 MKK6 诱导的 p38 MAPK 磷酸化，IC₅₀ 值为 19 nM。具有抗肿瘤和抗银屑病功效。

HY-P10438

TAT-Braftide	Raf	Cancer
TAT-Braftide 是一种肽抑制剂，目的是阻断 BRAF 的二聚化，从而抑制其激酶活性。TAT-Braftide 破坏 BRAF 二聚体后，使 BRAF 蛋白更易受到蛋白酶体的降解，直接抑制 BRAF 激酶的活性，减少 MAPK 信号通路的激活。Tat-braftide 可用于 RAF 激酶在 MAPK 信号通路中作用以及针对 BRAF 突变癌症的研究。

HY-152087

DCZ19931	ERK p38 MAPK	Cardiovascular Disease
DCZ19931 是一种有效的多靶向激酶抑制剂。DCZ19931 对眼部新生血管有抗血管生成作用。DCZ19931 还抑制 ERK1/2-MAPK 和 p38-MAPK 信号。

HY-112181

KO-947 4 篇文献验证	ERK	Cancer
KO-947是有效和选择性的 ERK1/2 激酶抑制剂，在MAPK途径失调的肿瘤中具有潜在效用。

HY-161293

p38-α MAPK-IN-6	p38 MAPK	Cancer
p38-α MAPK-IN-6 (compound 3a) 是 p38α 丝裂原激活蛋白激酶抑制剂。

HY-120485

Raxofelast IRFI-016	p38 MAPK ERK PKC	Cardiovascular Disease
Raxofelast (IRFI-016) 是一种抗氧化剂，适用于各种缺血再灌注损伤模型。 Raxofelast 在 H₂O₂MAPK), ERK 激酶 1, 2 (MEK1,2) 和蛋白激酶 C (PKC) 的激活而不影响 Ras 表达。

HY-Z3832

N-Methylparoxetine	Apoptosis p38 MAPK Autophagy	Cancer
N-甲基帕罗西汀 N-Methylparoxetine 是 Paroxetine 的一种衍生物，通过激活丝裂原活化蛋白激酶（*MAPK）途径诱导 NSCLC 细胞凋亡 (Apoptosis*)。N-Methylparoxetine 具有抗肿瘤活性。

HY-145027

ERK1/2 inhibitor 5	ERK	Cancer
ERK1/2 inhibitor 5 是一种有效的ERK1/2抑制剂。丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中起着极其重要的作用，而细胞外信号调节激酶 (ERK) 是MAPK家族的成员。ERK1/2 inhibitor 5 具有研究或预防癌症、炎症或其他增殖性疾病的潜力 (信息提取自专利 WO2020238776A1)。

HY-145026

ERK1/2 inhibitor 4	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 5 是一种有效的ERK1/2抑制剂。丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中起着极其重要的作用，而细胞外信号调节激酶 (ERK) 是MAPK家族的成员。ERK1/2 inhibitor 5 具有研究或预防癌症、炎症或其他增殖性疾病的潜力 (信息提取自专利 WO2020238776A1)。

HY-175431

p38 MAPK-IN-8	p38 MAPK	Inflammation/Immunology Cancer
p38 MAPK-IN-8 (Compound 8) 是一种具有口服活性、有效且选择性的 p38 丝裂原活化蛋白激酶 (p38 MAPK) 抑制剂。p38 MAPK-IN-8 有望用于炎症反应、自身免疫性疾病和癌症的研究。

HY-145025

ERK1/2 inhibitor 3	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 3 是一种有效的ERK1/2抑制剂。丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中起着极其重要的作用，而细胞外信号调节激酶 (ERK) 是MAPK家族的成员。ERK1/2 inhibitor 3 具有研究或预防癌症、炎症或其他增殖性疾病的潜力 (信息提取自专利 WO2021218912A1, 化合物 1)。

HY-N1966

(E)-Osmundacetone 2 篇文献验证	p38 MAPK JNK ERK	Neurological Disease
(E)-紫萁酮 (E)-Osmundacetone 是 Osmundacetone 的异构体。Osmundacetone 可以显着抑制 MAPK 磷酸化，包括 JNK，ERK 和 p38 激酶，具有抗氧化应激的神经保护作用。

HY-12072

Lck Inhibitor 2 篇文献验证	Src	Inflammation/Immunology
Lck Inhibitor 是一种有效的口服活性淋巴细胞特异性激酶 (Lck) 抑制剂，对 Lck，Lyn，Src 和 Syk 激酶的 IC₅₀ 分别为 7、2.1、4.2 和 200 nM。与 MAPK，CDK 和 RSK 家族代表相比，Lck Inhibitor 对 Lck 的选择性高出 1000 倍以上。Lck Inhibitor 抑制 T 细胞增殖和关节炎模型。

HY-110193

SPP-86 2 篇文献验证	RET	Cancer
SPP-86 是一种选择性的 RET 酪氨酸激酶的有效抑制剂，其 IC₅₀ 值为 8 nM。SPP-86 抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路，也能抑制 RET 诱导的 ERα 磷酸化。

HY-175432

p38 MAPK-IN-9	p38 MAPK	Inflammation/Immunology
p38 MAPK-IN-9 (Compound 15) 是一种具有口服活性，高选择性的 p38α MAP 激酶 (p38 MAPK) 的抑制剂，IC₅₀ 值为 9.6 nM。p38 MAPK-IN-9 有望用于类风湿性关节炎、脓毒症休克及慢性阻塞性肺病等炎症性疾病的研究。

HY-P10436

Braftide	Raf	Cancer
Braftide 是一种 BRAF 激酶变构抑制剂，通过靶向 BRAF 激酶二聚体表面，抑制 BRAF 二聚体的形成，发挥抑制作用。Braftide 抑制野生型 BRAF 和致癌型 BRAF^G469A，IC₅₀ 分别为 364 nM 和 172 nM。Braftide 与 TAT 序列结合使用，可以抑制 MAPK 信号通路，抑制 KRAS 突变肿瘤细胞的增殖 (对于 HCT116 和 HCT-15，EC₅₀ 分别为 7.1 和 6.6 μM)。

HY-100278

AKP-001	p38 MAPK	Inflammation/Immunology
AKP-001 是一种 p38 丝裂原活化蛋白激酶 (p38 MAPK) 抑制剂。AKP-001 可以抑制炎性细胞因子的产生，可用于风湿性关节炎和炎症性肠病的研究。

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Others
DB1113 (Example 24) 是一种靶向蛋白激酶降解的双功能化合物。DB1113 可降解 ABL1，ABL2，BLK，CDK11B，CDK4，CSK，EPHA3，FER，GAK，LIMK1，MAP3K20，MAP4K1，MAP4K2，MAP4K3，MAP4K5，MAPK14，MAPK7，MAPK8，MAPK9，MAPKAPK2，MAPKAPK3，NLK，PDIK1L，PTK2B，RIPK1，RPS6KA1，RPS6KA3，SIK2，SIK3，STK35，TNK2 和 ULK1。DB1113 可用于研究异常激酶活性介导的疾病或紊乱。

HY-172787

FGFR4-IN-23	FGFR Akt AMPK	Cancer
FGFR4-IN-23 (compound 48c) 是一种 FGFR4 抑制剂，对 FGFR4^WT激酶的 IC₅₀ 值为 2.9 nM。FGFR4-IN-23 抑制 FGFR4、AKT 和 *MAPK* 的磷酸化。

HY-160469

INY-05-040	Akt PROTACs	Cancer
INY-05-040 是一种 AKT 降解剂，能够选择性地快速降解所有三种 AKT 亚型。INY-05-040 具有抗癌活性。INY-05-040 可抑制 288 种癌细胞系中的下游信号传导和细胞增殖。INY-05-040 可以抑制 AKT 信号传导并诱导应激丝裂原活化蛋白激酶 (*MAPK) c-Jun 氨基端激酶 (JNK)。INY-05-040 对应激 MAPK* 通路低基线激活的乳腺癌细胞系有效。INY-05-040 可用于抗癌研究。

HY-136990

GLPG0259	Others	Cancer
GLPG0259 是 MAPK 活化蛋白激酶 5 (MK5) 的 ATP 竞争性抑制剂，具有口服活性。GLPG0259 可减少小鼠胶原诱导的关节炎模型中的炎症和骨破坏。GLPG0259 还抑制前列腺癌 (PCa) 细胞的转移。

HY-112345

PD-089828	FGFR PDGFR EGFR Src	Cancer
PD-089828 是 ATP 竞争性 FGFR-1、PDGFR-β 和 EGFR (IC₅₀ 分别为 0.15, 1.76, 5.47 µM) 抑制剂和 c-Src 酪氨酸激酶非竞争性抑制剂 (IC₅₀=0.18 µM)。PD-089828 也抑制 *MAPK，IC₅₀* 值为 7.1 µM。PD-089828 体外抑制 PDGF-、EGF- 和 bFGF 介导的酪氨酸激酶受体的自磷酸化。PD-089828 具有持久的细胞活性。

HY-P10414

Klotho-derived peptide 1 KP1 (human)	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) 可阻断 TGF-β/TGF-β 受体 2 的相互作用，抑制 TGF-β 诱导的 Smad2/3 和丝裂原活化蛋白激酶 (MAPK) 激活，并在小鼠模型中表现出抗纤维化和肾脏保护作用。

HY-P10414A

Klotho-derived peptide 1 hydrochloride KP1 (human) (hydrochloride)	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) hydrochloride 可阻断 TGF-β/TGF-β 受体 2 的相互作用，抑制 TGF-β 诱导的 Smad2/3 和丝裂原活化蛋白激酶 (MAPK) 激活，并在小鼠模型中表现出抗纤维化和肾脏保护作用。

HY-14974

R 1487	p38 MAPK	Inflammation/Immunology
R 1487 是一种有口服活性，高选择性的 p38α 丝裂原活化蛋白激酶抑制剂。R 1487 可用于类风湿关节炎的研究。

HY-10406A

Talmapimod hydrochloride SCIO-469 hydrochloride	p38 MAPK	Cancer
他匹莫德盐酸盐 Talmapimod (SCIO-469) hydrochloride 是 p38α 选择性的，具有口服活性的，ATP 竞争性的抑制剂，IC₅₀ 值是 9 nM，约为 p38β 的 10 倍，在 20 个其他激酶 (包括其他 MAPKs) 上显示出至少 2000 倍的选择性。

HY-10406

Talmapimod 3 篇文献验证 SCIO-469	p38 MAPK	Cancer
他匹莫德 Talmapimod (SCIO-469) 是 p38α 选择性的，具有口服活性的，ATP 竞争性的抑制剂，IC₅₀ 值是 9 nM，约为 p38β 的10倍，在 20 个其他激酶 (包括其他 MAPKs) 上显示出至少 2000 倍的选择性。

HY-135906

CK2/ERK8-IN-1 2 篇文献验证	Casein Kinase ERK Pim DYRK Apoptosis	Cancer
CK2/ERK8-IN-1 是一种酪蛋白激酶 2 (CK2) (K_i 为 0.25 µM) 和 ERK8 (MAPK15, ERK7) 的双重抑制剂，IC₅₀ 均为 0.50 μM。CK2/ERK8-IN-1 还与 PIM1，HIPK2 和 DYRK1A 结合，K_i 值分别为 8.65 µM，15.25 µM 和 11.9 µM。CK2/ERK8-IN-1 具有促凋亡 (pro-apoptotic) 作用。

HY-137092

IACS-13909 3 篇文献验证	SHP2 Phosphatase	Cancer
IACS-13909 是一种有效的选择性的，具有口服活性的 SHP2 变构抑制剂，其 IC₅₀ 为 15.7 nM，K_d 为 32 nM。与其他磷酸酶 (包括 SHP1) 相比，IACS-13909 对 SHP2 的选择性更高。IACS-13909 抑制受体酪氨酸激酶 (RTK)/MAPK 途径的信号传导，并具有抗癌作用。

HY-N6246

Asperulosidic Acid	NF-κB ERK	Inflammation/Immunology Cancer
车叶草苷酸 Asperulosidic Acid (ASPA) 车叶草苷酸是一种具有生物活性的环烯醚萜苷，从白花蛇舌草 (Hedyotis diffusa Willd) 的草药中提取的。 Asperulosidic Acid (ASPA) 具有抗肿瘤，抗氧化和抗炎作用。 Asperulosidic Acid (ASPA) 通过抑制 NF-κB 和丝裂原活化蛋白激酶 (*MAPK*) 信号通路抑制炎性细胞因子(TNF-α，IL-6) 释放发挥抗炎作用。

HY-P10954

Link N peptide	p38 MAPK	Others
Link N peptide 是一种细胞外基质中的蛋白聚糖聚集体 (proteoglycan aggregates) 激活剂。Link N peptide 能够选择性激活 p38 丝裂原活化蛋白激酶 (MAPK) 通路，促进人椎间盘细胞中 I 型和 II 型胶原蛋白的表达。Link N peptide 有望用于椎间盘退变相关疾病的研究。

HY-111820

CK1-IN-1	Casein Kinase p38 MAPK	Cardiovascular Disease
CK1-IN-1 (Compound 1c) 是一种酪蛋白激酶 1 (CK1) 抑制剂，对 CK1δ、CK1ε 的 IC₅₀ 值分别为 15 nM 和 16 nM。CK1-IN-1 抑制 p38α MAPK，IC₅₀ 为 73 nM。CK1-IN-1 可用于心肌生成研究。

HY-116035

Nimbolide 1 篇文献验证	Wnt NF-κB CDK Apoptosis	Cancer
印苦楝内酯 Nimbolide 是可以从印楝 (Azadirachta indica) 中分离得到的一种三萜化合物，具有抗癌和抗增殖活性。Nimbolide 通过抑制 NF-κB 和 CDK4/CDK6 激酶，诱导肿瘤细胞凋亡。Nimbolide 抑制 Wnt、PI3K-Akt、MAPK 和 JAK-STAT 信号通路。

HY-108645

AL 8697	p38 MAPK Autophagy	Inflammation/Immunology
AL 8697 是一种特异性的，具有口服活性的 p38α MAPK 抑制剂，IC₅₀ 为 6 nM。与 p38β (IC₅₀=82 nM) 相比，AL 8697 对 p38α 的抑制作用强 14 倍，对 p38α 的选择性比其他 91 种激酶高 300 倍。具有抗炎活性。

HY-N12726

Halociline	p38 MAPK MMP	Infection Inflammation/Immunology Cancer
Halociline 是一种可从海洋真菌 Penicillium griseofulvum (灰绿青霉) 中分离出的生物碱衍生物。Halociline 针对胃癌细胞中的MAPK1、MMP-9 和 PIK3CA，其作用可能通过包括癌症、脂质代谢、动脉粥样硬化和EGFR酪氨酸激酶抑制剂抗性等多种途径介导。Halociline 具有抗菌、抗氧化和抑制生物膜活性的特性。

Cat. No.	Product Name

HY-L164

丝氨酸/苏氨酸激酶抑制剂库

1,859 compounds

丝氨酸/苏氨酸激酶 (protein serine/threonine kinases, PSKs) 是一种以 ATP 为高能供体分子，将磷酸基团转移到底物蛋白的丝氨酸/苏氨酸残基上的蛋白激酶。丝氨酸/苏氨酸激酶作为一种重要的信号传导调控因子，通过影响靶蛋白的酶活性或干扰靶蛋白与其他蛋白的结合影响靶蛋白的功能，参与调控免疫反应以及细胞的增殖、分化、凋亡等生理过程。丝氨酸/苏氨酸激酶抑制剂是一类重要的化合物，被广泛运用于癌症、慢性炎症、自身免疫性疾病、衰老等疾病的研究。

MCE 精心收录了1,859种丝氨酸/苏氨酸激酶抑制剂，主要靶向蛋白激酶 A (PKA)、蛋白激酶 B (Akt)、蛋白激酶 C (PKC)、丝裂原活化蛋白激酶/细胞外信号调节激酶 (MAPK/ERK) 等，是癌症、慢性炎症疾病、自身免疫性疾病、衰老等相关药物研究的有效工具。

HY-L010

MAPK 化合物库

832 compounds

MAPK 家族在复杂的细胞增殖、分化、发育、转化、凋亡等过程中发挥重要作用。在哺乳动物细胞中，发现有四种类型的 MAPK 级联通路，ERK1/2 信号通路，JNK 信号通路，p38 激酶信号通路和 ERK5 信号通路，他们会对不同的信号产生反应。MAPK 通路包含一组三级磷酸化依赖的激酶，包括 MAPK 激酶激酶 (MKKK) 、MAPK 激酶 (MKK) 和 MAPK。MAPK 信号通路参与多种疾病的发生，如阿尔茨海默病 (AD)，帕金森病 (PD)，肌萎缩性脊髓侧索硬化症 (ALS) 和各种癌症。

MCE 收集的 832 种 MAP K信号相关抑制剂，是 MAPK 相关的药物筛选和疾病研究的有用工具。

Cat. No.	Product Name	Target	Research Area

HY-P10072A

MK2-IN-5 acetate Hsp25 Kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate 是 Mk2 的假底物 (K_i= 8 μM)。MK2-IN-5 acetate 靶向 MAPK 通路中的蛋白相互作用域。MK2-IN-5 acetate 抑制 HSP25 和 HSP27 的磷酸化。

HY-P10438

TAT-Braftide	Raf	Cancer
TAT-Braftide 是一种肽抑制剂，目的是阻断 BRAF 的二聚化，从而抑制其激酶活性。TAT-Braftide 破坏 BRAF 二聚体后，使 BRAF 蛋白更易受到蛋白酶体的降解，直接抑制 BRAF 激酶的活性，减少 MAPK 信号通路的激活。Tat-braftide 可用于 RAF 激酶在 MAPK 信号通路中作用以及针对 BRAF 突变癌症的研究。

HY-P10436

Braftide	Raf	Cancer
Braftide 是一种 BRAF 激酶变构抑制剂，通过靶向 BRAF 激酶二聚体表面，抑制 BRAF 二聚体的形成，发挥抑制作用。Braftide 抑制野生型 BRAF 和致癌型 BRAF^G469A，IC₅₀ 分别为 364 nM 和 172 nM。Braftide 与 TAT 序列结合使用，可以抑制 MAPK 信号通路，抑制 KRAS 突变肿瘤细胞的增殖 (对于 HCT116 和 HCT-15，EC₅₀ 分别为 7.1 和 6.6 μM)。

HY-P10414A

Klotho-derived peptide 1 hydrochloride KP1 (human) (hydrochloride)	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) hydrochloride 可阻断 TGF-β/TGF-β 受体 2 的相互作用，抑制 TGF-β 诱导的 Smad2/3 和丝裂原活化蛋白激酶 (MAPK) 激活，并在小鼠模型中表现出抗纤维化和肾脏保护作用。

HY-P10954

Link N peptide	p38 MAPK	Others
Link N peptide 是一种细胞外基质中的蛋白聚糖聚集体 (proteoglycan aggregates) 激活剂。Link N peptide 能够选择性激活 p38 丝裂原活化蛋白激酶 (MAPK) 通路，促进人椎间盘细胞中 I 型和 II 型胶原蛋白的表达。Link N peptide 有望用于椎间盘退变相关疾病的研究。

HY-P10367

Ziptide	MAPKAPK2 (MK2) Checkpoint Kinase (Chk) AMPK	Others
Ziptide 是多种激酶的底物，如 MAPK蛋白激酶 2 (MAPKAPK2, K_m = 5 μM)、MAPKAPK3 (K_m = 30 μM)、PARK (K_m = 40 μM)、checkpoint kinase 1 (Chk1, K_m = 5 μM), AMP激活蛋白激酶 (AMPK, K_m = 75 μM) 以及钙/钙调素依赖性蛋白激酶 II (CamKII, K_m = 300 μM)。

HY-P10414

Klotho-derived peptide 1 KP1 (human)	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) 可阻断 TGF-β/TGF-β 受体 2 的相互作用，抑制 TGF-β 诱导的 Smad2/3 和丝裂原活化蛋白激酶 (MAPK) 激活，并在小鼠模型中表现出抗纤维化和肾脏保护作用。

Cat. No.	Product Name	Target	Research Area

HY-P99463

Batiraxcept AVB-500; AVB-S6-500	TAM Receptor PI3K Akt p38 MAPK	Cancer
Batiraxcept (AVB-500；AVB-S6-500) 是一种选择性、可溶性 AXL 受体和 GAS6 抑制剂，靶向 GAS6-AXL 信号轴。Batiraxcept 无口服活性，无法通过血脑屏障。Batiraxcept 竞争性结合 GAS6 ((K_D <1 nM)，阻止其与 AXL 受体酪氨酸激酶相互作用，从而抑制下游 PI3K/AKT 和 *MAPK* 信号通路，减少肿瘤细胞糖酵解、血管生成和转移潜力。Batiraxcept 在子宫内膜癌、胆管癌和卵巢癌等临床前模型中通过抑制肿瘤生长、侵袭和转移展现抗肿瘤活性。

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0031

Plantamajoside 2 篇文献验证	Plantaginaceae Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plantago asiatica L. Plants Inflammation/Immunology Disease Research Fields	NF-κB PI3K Akt Apoptosis Autophagy p38 MAPK Src
车前子甙 Plantamajoside 是一种具有口服活性的苯丙烷类糖苷。Plantamajoside 可从车前 Plantago asiatica L. 中分离出来。Plantamajoside 失活 NF-κB, PI3K/akt, 诱导凋亡 (Apoptosis), 改善自噬 (Autophagy)。Plantamajoside 调节 *MAPK, integrin-linked kinase/c-Src*。Plantamajoside 抑制多种癌症，改善肺、肾损伤。Plantamajoside 具有神经保护和抗炎作用。

HY-N1966

(E)-Osmundacetone 2 篇文献验证	Microorganisms Source classification Phenols Polyphenols	p38 MAPK JNK ERK
(E)-紫萁酮 (E)-Osmundacetone 是 Osmundacetone 的异构体。Osmundacetone 可以显着抑制 MAPK 磷酸化，包括 JNK，ERK 和 p38 激酶，具有抗氧化应激的神经保护作用。

HY-N6246

Asperulosidic Acid	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields	NF-κB ERK
车叶草苷酸 Asperulosidic Acid (ASPA) 车叶草苷酸是一种具有生物活性的环烯醚萜苷，从白花蛇舌草 (Hedyotis diffusa Willd) 的草药中提取的。 Asperulosidic Acid (ASPA) 具有抗肿瘤，抗氧化和抗炎作用。 Asperulosidic Acid (ASPA) 通过抑制 NF-κB 和丝裂原活化蛋白激酶 (*MAPK*) 信号通路抑制炎性细胞因子(TNF-α，IL-6) 释放发挥抗炎作用。

HY-116035

Nimbolide 1 篇文献验证	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Azadirachta indica A. Juss. Plants Meliaceae Disease Research Fields Cancer	Wnt NF-κB CDK Apoptosis
印苦楝内酯 Nimbolide 是可以从印楝 (Azadirachta indica) 中分离得到的一种三萜化合物，具有抗癌和抗增殖活性。Nimbolide 通过抑制 NF-κB 和 CDK4/CDK6 激酶，诱导肿瘤细胞凋亡。Nimbolide 抑制 Wnt、PI3K-Akt、MAPK 和 JAK-STAT 信号通路。

HY-16558

Butein 5 篇文献验证 2’,3,4,4’-tetrahydroxy Chalcone	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
紫铆因 Butein 是一种 cAMP 特异性的 PDE 抑制剂，对 PDE4 的 IC₅₀为 10.4 μM。Butein 是蛋白酪氨酸激酶抑制剂，对 EGFR 和 p60^c-src 的 IC₅₀ 分别为 16 和 65 μM。Butein 通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。Butein 还是一种 SIRT1 激活剂 (STAC)。

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	Structural Classification Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants	p38 MAPK
3-脱氧苏木酮 B Deoxysappanone B (3-Deoxysappanone B) 是一种从 Caesalpinia sappan L (Lignum Sappan) 分离得到的异黄酮化合物。Deoxysappanone B 具有抗神经炎症和神经保护作用，可以通过阻断 IκB kinase (IKK)-NF-κB 和 p38/ERK MAPK 途径的信号通路，抑制神经炎症介质的产生。Deoxysappanone B 可用于神经炎和炎症相关的神经损伤的疾病研究。

HY-N0031R

Plantamajoside (Standard)	Plantaginaceae Structural Classification Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plantago asiatica L. Plants	Reference Standards NF-κB PI3K Apoptosis Autophagy p38 MAPK Src
车前子甙 (Standard) Plantamajoside (Standard) 是 Plantamajoside 的分析标准品。本产品用于研究及分析应用。Plantamajoside 是一种具有口服活性的苯丙烷类糖苷。Plantamajoside 可从车前 Plantago asiatica L. 中分离出来。Plantamajoside 失活 NF-κB, PI3K/akt, 诱导凋亡 (Apoptosis), 改善自噬 (Autophagy)。Plantamajoside 调节 *MAPK, integrin-linked kinase/c-Src*。Plantamajoside 抑制多种癌症，改善肺、肾损伤。Plantamajoside 具有神经保护和抗炎作用。

HY-N12726

Halociline	Structural Classification Microorganisms Marine natural products Source classification Phenols Marine microorganism	p38 MAPK MMP
Halociline 是一种可从海洋真菌 Penicillium griseofulvum (灰绿青霉) 中分离出的生物碱衍生物。Halociline 针对胃癌细胞中的MAPK1、MMP-9 和 PIK3CA，其作用可能通过包括癌症、脂质代谢、动脉粥样硬化和EGFR酪氨酸激酶抑制剂抗性等多种途径介导。Halociline 具有抗菌、抗氧化和抑制生物膜活性的特性。

HY-N6246R

Asperulosidic Acid (Standard)	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Morinda officinalis How	Reference Standards NF-κB ERK
车叶草苷酸 (Standard) Asperulosidic Acid (Standard) 是 Asperulosidic Acid 的分析标准品。本产品用于研究及分析应用。Asperulosidic Acid (ASPA) 车叶草苷酸是一种具有生物活性的环烯醚萜苷，从白花蛇舌草 (Hedyotis diffusa Willd) 的草药中提取的。 Asperulosidic Acid (ASPA) 具有抗肿瘤，抗氧化和抗炎作用。 Asperulosidic Acid (ASPA) 通过抑制 NF-κB 和丝裂原活化蛋白激酶 (*MAPK*) 信号通路抑制炎性细胞因子(TNF-α，IL-6) 释放发挥抗炎作用。

HY-116035R

Nimbolide (Standard)	Triterpenes Structural Classification Terpenoids Source classification Azadirachta indica A. Juss. Plants Meliaceae	Wnt NF-κB CDK Apoptosis
印苦楝内酯 (Standard) Nimbolide (Standard）是 Nimbolide 的分析标准品。本产品用于研究及分析应用。Nimbolide 是可以从印楝 (Azadirachta indica) 中分离得到的一种三萜化合物，具有抗癌和抗增殖活性。Nimbolide 通过抑制 NF-κB 和 CDK4/CDK6 激酶，诱导肿瘤细胞凋亡。Nimbolide 抑制 Wnt、PI3K-Akt、MAPK 和 JAK-STAT 信号通路。

HY-N0632

Esculentoside A 2 篇文献验证	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Phytolacca acinosa Roxb. Plants Inflammation/Immunology Disease Research Fields Phytolaccaceae	COX NF-κB
商陆皂苷甲 Esculentoside A (EsA)，一种从商陆 Phytolacca esculenta 根部分离出来的三萜皂苷。 Esculentoside A (EsA) 在具有抗炎活性，对环氧合酶-2 (COX-2) 具有选择性抑制活性。 Esculentoside A (EsA) 通过抑制 (NF-ΚB) 和丝裂原活化蛋白激酶 (*MAPK*) 信号通路抑制 LPS 诱导的急性肺损伤 (ALI) 中的炎症反应。

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Structural Classification Chalcones Flavonoids other families Source classification Phenols Polyphenols Plants	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
紫铆因 (Standard) Butein (Standard) 是 Butein 的分析标准品。本产品用于研究及分析应用。Butein 是一种 cAMP 特异性的 PDE 抑制剂，对 PDE4 的 IC₅₀为 10.4 μM。Butein 是蛋白酪氨酸激酶抑制剂，对 EGFR 和 p60^c-src 的 IC₅₀ 分别为 16 和 65 μM。Butein 通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。Butein 还是一种 SIRT1 激活剂 (STAC)。

HY-N0632R

Esculentoside A (Standard)	Triterpenes Structural Classification Terpenoids Source classification Phytolacca acinosa Roxb. Plants Phytolaccaceae	Reference Standards COX NF-κB
商陆皂苷甲 (Standard) Esculentoside A (Standard) 是 Esculentoside A 的分析标准品。本产品用于研究及分析应用。Esculentoside A (EsA)，一种从商陆 Phytolacca esculenta 根部分离出来的三萜皂苷。 Esculentoside A (EsA) 在具有抗炎活性，对环氧合酶-2 (COX-2) 具有选择性抑制活性。 Esculentoside A (EsA) 通过抑制 (NF-ΚB) 和丝裂原活化蛋白激酶 (*MAPK*) 信号通路抑制 LPS 诱导的急性肺损伤 (ALI) 中的炎症反应。

HY-N0818

Chikusetsusaponin Iva 2 篇文献验证 Calenduloside F	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb. Disease Research Fields	Keap1-Nrf2
竹节人参皂苷 IVA Chikusetsusaponin IVa 是一种口服活性的蛋白激酶激活剂。Chikusetsusaponin IVa 与 YAP 结合，其 K_D 值为 0.388 mM。Chikusetsusaponin IVa 可降低炎症介质 (IL-6、IL-10、COX-2) 表达和 NO 产生，促进 ROS 生成，诱导 (Apoptosis)，抑制 *MAPK、TAZ，并调节 Nrf2* 和 JAK/STAT。Chikusetsusaponin IVa 具有抗 H9N2 AIV 病毒和抗子宫内膜癌活性。Chikusetsusaponin IVa 具有抗炎、保肝和骨保护作用。

HY-W100287

Murrayafoline A	Structural Classification Alkaloids Murraya tetramera C. C. Huang Source classification Rutaceae Carbazole Alkaloids Plants	NF-κB p38 MAPK Interleukin Related IKK JNK β-catenin Wnt
Murrayafoline A 是一种可以从 Murraya tetramera 中提取的咔唑类生物碱。Murrayafoline A 直接靶向特异性蛋白 1 (Sp1)，从而抑制 NF-κB 和 *MAPK* 信号通路。Murrayafoline A 在血小板衍生生长因子 (PDGF) 刺激的血管平滑肌细胞中诱导 G0/G1 期阻滞。Murrayafoline A 通过促进细胞内 β-catenin 的降解减弱 Wnt/β-catenin 途径。Murrayafoline A 通过激活蛋白激酶 C 增强大鼠心室肌细胞的收缩和 L 型钙电流。Murrayafoline A 抑制体内 LPS (HY-D1056) 诱导的神经炎症。Murrayafoline A 可用于炎症、血管并发症和结肠癌研究。

Species:	Human (39) Mouse (2)
Tag:	His (19) Tag Free (9) Strep (2) GST (17) Flag (2)
Source:	Sf9 insect cells (2) Sf9 insect cells (20) P. pastoris (1) E. coli (18)

Cat. No.	Compare	Product Name	Species	Source

HY-P701678

	ERK1 Protein, Human (GST) MAPK3; Mitogen-activated protein Kinase 3; MAP Kinase 3; MAPK 3; ERT2; Extracellular signal-regulated Kinase 1; ERK-1; Insulin-stimulated MAP2 Kinase; MAP Kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 Kinase; p44-ERK1	Human	E. coli
	ERK1 蛋白 ERK1蛋白是MAP激酶途径中重要的丝氨酸/苏氨酸激酶，与MAPK1/ERK2配合激活MAPK/ERK级联。在 KIT 和 KITLG/SCF 的刺激下，该通路在细胞生长、粘附、存活和分化中发挥着关键作用。ERK1 Protein, Human (GST) 是重组的 ERK1 蛋白，由 E. coli 表达，带有 N-GST 标签。

HY-P701803

	MAPK4 Protein, Human (sf9, His, GST) MAPK4; Mitogen-activated protein Kinase 4; MAP Kinase 4; MAPK 4; Extracellular signal-regulated Kinase 4; ERK-4; MAP Kinase isoform p63; p63-MAPK	Human	Sf9 insect cells
	MAPK4 蛋白 MAPK4 是一种非典型 MAPK 蛋白，可磷酸化微管相关蛋白 2 (MAP2) 和 MAPKAPK5，形成具有复杂磷酸化事件的复合物。与 MAPKAPK5 的相互作用导致 ERK3/MAPK6 在 Ser-189 处磷酸化，从而激活 MAPKAPK5，从而相互磷酸化 ERK3/MAPK6。这种相互作用的具体细胞作用虽然尚不清楚，但表明 ERK3 可能参与促进进入细胞周期。MAPK4 Protein, Human (sf9, His, GST) 是重组的 MAPK4 蛋白，由 sf9 insect cells 表达，带有 N-8*His, N-GST 标签。

HY-P701679

	ERK3 Protein, Human (L290V) MAPK6; Mitogen-activated protein Kinase 6; MAP Kinase 6; MAPK 6; Extracellular signal-regulated Kinase 3; ERK-3; MAP Kinase isoform p97; p97-MAPK	Human	E. coli
	ERK3 蛋白 ERK3 蛋白是一种非典型 MAPK，磷酸化 MAP2 和 MAPKAPK5。ERK3/MAPK6 与 MAPKAPK5 相互作用，发生 Ser-189 磷酸化，促进 MAPKAPK5 激活。激活的 MAPKAPK5 会相互磷酸化 ERK3/MAPK6。该复合物的精确功能意义，特别是在细胞周期进入方面，仍然难以捉摸。ERK3 Protein, Human (L290V) 是重组的 ERK3 蛋白，由 E. coli 表达，不带标签。

HY-P701680

	ERK3 Protein, Human (L290V, His) MAPK6; Mitogen-activated protein Kinase 6; MAP Kinase 6; MAPK 6; Extracellular signal-regulated Kinase 3; ERK-3; MAP Kinase isoform p97; p97-MAPK	Human	E. coli
	ERK3 蛋白 ERK3 蛋白是一种非典型 MAPK，磷酸化 MAP2 和 MAPKAPK5。ERK3/MAPK6 与 MAPKAPK5 相互作用，发生 Ser-189 磷酸化，促进 MAPKAPK5 激活。激活的 MAPKAPK5 会相互磷酸化 ERK3/MAPK6。该复合物的精确功能意义，特别是在细胞周期进入方面，仍然难以捉摸。ERK3 Protein, Human (L290V, His) 是重组的 ERK3 蛋白，由 E. coli 表达，带有 N-6*His 标签。

HY-P702735

	MAPK1/ERK2 Protein, Human (Flag, His) MAPK1; mitogen-activated protein Kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41MAPK; ERK-2; MAPK 2; p42-MAPK; MAP Kinase 1; MAP Kinase 2; MAP Kinase isoform p42; protein tyrosine Kinase ERK2; mitogen-activated protein Kinase 2; extracellular signal-regulated Kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	MAPK1 蛋白/ERK2 蛋白 ERK2 蛋白是 MAPK/ERK 级联的关键组成部分，调节多种细胞过程，如转录、翻译、有丝分裂、细胞凋亡、内体动力学和高尔基体断裂。通过磷酸化，它调节底物，包括转录因子、细胞骨架元件、细胞凋亡调节因子、翻译调节因子、蛋白激酶和磷酸酶。MAPK1 Protein, Human (Flag, His) 是重组的 MAPK1 蛋白，由 E. coli 表达，带有 His, Flag 标签。

HY-P704008

	MAPK1/ERK2 Protein, Human (Inactive, GST) MAPK1; mitogen-activated protein Kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41MAPK; ERK-2; MAPK 2; p42-MAPK; MAP Kinase 1; MAP Kinase 2; MAP Kinase isoform p42; protein tyrosine Kinase ERK2; mitogen-activated protein Kinase 2; extracellular signal-regulated Kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	MAPK1 蛋白/ERK2 蛋白 ERK2 蛋白是 MAPK/ERK 级联的关键组成部分，调节多种细胞过程，如转录、翻译、有丝分裂、细胞凋亡、内体动力学和高尔基体断裂。通过磷酸化，它调节底物，包括转录因子、细胞骨架元件、细胞凋亡调节因子、翻译调节因子、蛋白激酶和磷酸酶。MAPK1/ERK2 Protein, Human (Inactive, GST) 是重组的 MAPK1/ERK2 蛋白，由 E. coli 表达，带有 N-GST 标签。

HY-P705421

	JNK1 Protein, Mouse (Active, sf9, GST) MAP Kinase 8; MAPK 8; Stress-activated protein Kinase JNK1; c-Jun N-terminal Kinase 1; MAPK8	Mouse	Sf9 insect cells

HY-P701791

	JNK3 Protein, Human (His) MAPK10; Mitogen-activated protein Kinase 10; MAP Kinase 10; MAPK 10; MAP Kinase p49 3F12; Stress-activated protein Kinase 1b; SAPK1b; Stress-activated protein Kinase JNK3; c-Jun N-terminal Kinase 3	Human	E. coli
	JNK3 蛋白 JNK3 是神经元过程中关键的丝氨酸/苏氨酸蛋白激酶，调节增殖、分化、迁移和凋亡。通过 MAP2K4/MKK4 和 MAP2K7/MKK7 激活会导致 JNK3 磷酸化，进而磷酸化 AP-1 成分（如 JUN 和 ATF2），从而调节 AP-1 转录活性。JNK3 Protein, Human (His) 是重组的 JNK3 蛋白，由 E. coli 表达，带有 N-6*His 标签。

HY-P703924

	p38 gamma/MAPK12 Protein, Human (Active, sf9, GST) Mitogen-activated protein Kinase 12; MAP Kinase 12; MAPK 12; Extracellular signal-regulated Kinase 6 (ERK-6); Mitogen-activated protein Kinase p38 gamma (MAP Kinase p38 gamma); Stress-activated protein Kinase 3	Human	Sf9 insect cells
	p38 gamma 蛋白/MAPK12 蛋白 p38 gamma/MAPK12 蛋白是 MAP 激酶通路中重要的丝氨酸/苏氨酸激酶，可以对促炎细胞因子或应激等细胞外刺激做出反应。p38 MAPK 激活转录因子，例如 ELK1 和 ATF2，每个转录因子可磷酸化大约 200 至 300 个底物。p38 gamma/MAPK12 Protein, Human (Active, sf9, GST) 是重组的 p38 gamma/MAPK12 蛋白，由 Sf9 insect cells 表达，带有 N-GST 标签。

HY-P701801

	MAP4K6 Protein, Human (sf9, GST) MINK1; Misshapen-like Kinase 1; GCK family Kinase MiNK; MAPK/ERK Kinase Kinase Kinase 6; MEK Kinase Kinase 6; MEKKK 6; Misshapen/NIK-related Kinase; Mitogen-activated protein Kinase Kinase Kinase Kinase 6	Human	Sf9 insect cells
	MAP4K6 蛋白 MAP4K6 蛋白是一种关键的丝氨酸/苏氨酸激酶，可负向调节 Ras 相关的 Rap2 介导的信号传导，影响神经元结构和 AMPA 受体运输。它在调节海马神经元突触密度、树突复杂性和表面 AMPA 受体表达方面的重要作用凸显了其重要性。MAP4K6 Protein, Human (sf9, GST) 是重组的 MAP4K6 蛋白，由 sf9 insect cells 表达，带有 N-GST 标签。

HY-P701814

	MKNK2 Protein, Human MKNK2; MAP Kinase-interacting serine/threonine-protein Kinase 2; MAP Kinase signal-integrating Kinase 2; MAPK signal-integrating Kinase 2; Mnk2	Human	E. coli
	MKNK2 蛋白 MKNK2 是一种丝氨酸/苏氨酸蛋白激酶，通过磷酸化 SFPQ/PSF、HNRNPA1 和 EIF4E 来集中影响细胞过程。MKNK2 位于环境应激和细胞因子信号转导的交叉点，通过增强 EIF4E 对 mRNA 帽的亲和力来调节翻译，从而影响翻译机制。MKNK2 Protein, Human 是重组的 MKNK2 蛋白，由 E. coli 表达，不带标签。

HY-P701705

	ASK1 Protein, Human (His) MAP3K5; Mitogen-activated protein Kinase Kinase Kinase 5; Apoptosis signal-regulating Kinase 1; ASK-1; MAPK/ERK Kinase Kinase 5; MEK Kinase 5; MEKK 5	Human	E. coli
	ASK1 蛋白 ASK1 蛋白是 MAP 激酶通路中的关键丝氨酸/苏氨酸激酶，协调细胞对环境变化的反应并影响细胞命运、分化和存活。ASK1 是细胞凋亡的关键参与者，可促进线粒体依赖性 caspase 激活。ASK1 Protein, Human (His) 是重组的 ASK1 蛋白，由 E. coli 表达，带有 C-6*His 标签。

HY-P702934

	MAPK15 Protein, Human (sf9, GST, StrepⅡ) Mitogen-activated protein Kinase 15 Curated; MAPK 15; Extracellular signal-regulated Kinase 7 (ERK-7); Extracellular signal-regulated Kinase 8 (ERK-8); MAPK15 Imported; ERK7 By similarity	Human	Sf9 insect cells
	MAPK15 蛋白 MAPK15 Protein, Human (sf9, GST, StrepII) 是重组的 MAPK15 蛋白，由 Sf9 insect cells 表达，带有 C-Strep, N-GST 标签。MAPK15 Protein, Human (sf9, GST, StrepII)

HY-P701815

	MKNK2 Protein, Human (His) MKNK2; MAP Kinase-interacting serine/threonine-protein Kinase 2; MAP Kinase signal-integrating Kinase 2; MAPK signal-integrating Kinase 2; Mnk2	Human	E. coli
	MKNK2 蛋白 MKNK2 是一种丝氨酸/苏氨酸蛋白激酶，通过磷酸化 SFPQ/PSF、HNRNPA1 和 EIF4E 来集中影响细胞过程。MKNK2 位于环境应激和细胞因子信号转导的交叉点，通过增强 EIF4E 对 mRNA 帽的亲和力来调节翻译，从而影响翻译机制。MKNK2 Protein, Human (His) 是重组的 MKNK2 蛋白，由 E. coli 表达，带有 N-6*His 标签。

HY-P701790

	JNK3 Protein, Human (364a.a, His) MAPK10; Mitogen-activated protein Kinase 10; MAP Kinase 10; MAPK 10; MAP Kinase p49 3F12; Stress-activated protein Kinase 1b; SAPK1b; Stress-activated protein Kinase JNK3; c-Jun N-terminal Kinase 3	Human	E. coli
	JNK3 蛋白 JNK3 是神经元过程中关键的丝氨酸/苏氨酸蛋白激酶，调节增殖、分化、迁移和凋亡。通过 MAP2K4/MKK4 和 MAP2K7/MKK7 激活会导致 JNK3 磷酸化，进而磷酸化 AP-1 成分（如 JUN 和 ATF2），从而调节 AP-1 转录活性。JNK3 Protein, Human 是重组的 JNK3 蛋白，由 E. coli 表达，不带标签。

HY-P700593

	MAP3K1 Protein, Mouse (His) MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1; MAP/ERK Kinase Kinase 1; MAPK/ERK Kinase Kinase 1; MEK Kinase 1; mitogen-activated protein Kinase Kinase Kinase 1, E3 ubiquitin protein ligase; mitogen-activated protein Kinase Kinase Kinase 1	Mouse	E. coli
	MAP3K1 蛋白 MAP3K1 是蛋白激酶信号转导级联的关键组成部分，在细胞信号传导通路中发挥着至关重要的作用。通过其激酶活性，MAP3K1 通过磷酸化 MAP2K1 和 MAP2K4 来协调 ERK 和 JNK 激酶途径的激活。MAP3K1 Protein, Mouse (His) 是重组的 MAP3K1 蛋白，由 E. coli 表达，带有 N-6*His 标签。

HY-P701813

	MKNK1 Protein, Human (sf9, GST) MKNK1; MAP Kinase-interacting serine/threonine-protein Kinase 1; MAP Kinase signal-integrating Kinase 1; MAPK signal-integrating Kinase 1; Mnk1	Human	Sf9 insect cells
	MKNK1 蛋白 MKNK1（MAP 激酶相互作用丝氨酸/苏氨酸激酶 1）在协调细胞对环境压力和细胞因子的反应中发挥着核心作用。它通过磷酸化 EIF4E 对翻译过程进行调控，增强其与 7-甲基鸟苷 mRNA 帽结构的亲和力。这凸显了 MKNK1 在微调翻译机制以响应不同的细胞刺激方面发挥着至关重要的作用。MKNK1 Protein, Human (sf9, GST) 是重组的 MKNK1 蛋白，由 sf9 insect cells 表达，带有 N-GST 标签。

HY-P703250

	MAP4K3 Protein, Human (sf9, GST, Flag) Mitogen-activated protein Kinase Kinase Kinase Kinase 3; Germinal center Kinase-related protein Kinase; GLK; MAPK/ERK Kinase Kinase Kinase 3; MEK Kinase Kinase 3; MEKKK 3; MAP4K3; RAB8IPL1; Homo sapiens; Human; GLK; Kinase; Serine/threonine-protein Kinase; Transferase; 2.7.11.1	Human	Sf9 insect cells
	MAP4K3 蛋白 MAP4K3 Protein, Human (sf9, GST, Flag) 是重组的 MAP4K3 蛋白，由 sf9 insect cells 表达，带有 GST, Flag 标签。MAP4K3 Protein, Human (sf9, GST, Flag)

HY-P702662

	MAPKAPK2 Protein, Human (323a.a) MAPKAPK2; mitogen-activated protein Kinase-activated protein Kinase 2; MAP Kinase-activated protein Kinase 2; MAPKAP Kinase 2; MAPK-activated protein Kinase 2; MK2; MK-2; MAPKAP-K2	Human	E. coli
	MAPKAPK2 蛋白 MAPKAPK2 蛋白是一种应激激活激酶，参与多种细胞过程，包括细胞因子产生、胞吞作用、细胞骨架重组、细胞迁移、细胞周期控制、染色质重塑、DNA 损伤反应和转录调节。MAPKAPK2 Protein, Human (323a.a) 是重组的 MAPKAPK2 蛋白，由 E. coli 表达，带有 tag Free 标签。

HY-P701804

	MAPKAPK2 Protein, Human MAPKAPK2; MAP Kinase-activated protein Kinase 2; MAPK-activated protein Kinase 2; MAPKAP Kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	Human	E. coli
	MAPKAPK2 蛋白 MAPKAPK2 蛋白是一种应激激活激酶，参与多种细胞过程，包括细胞因子产生、胞吞作用、细胞骨架重组、细胞迁移、细胞周期控制、染色质重塑、DNA 损伤反应和转录调节。MAPKAPK2 Protein, Human 是重组的 MAPKAPK2 蛋白，由 E. coli 表达，不带标签和 ΔH217-P237，S216G 突变。

HY-P701730

	P38β Protein, Human (sf9) MAPK11; Mitogen-activated protein Kinase 11; MAP Kinase 11; MAPK 11; Mitogen-activated protein Kinase p38 beta; MAP Kinase p38 beta; p38b; Stress-activated protein Kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	P38β 蛋白 P38β 蛋白是 MAP 激酶通路中重要的丝氨酸/苏氨酸激酶，可响应细胞外刺激，包括促炎细胞因子和身体应激。作为 p38 MAPK 家族的一部分，P38β 直接激活磷酸化许多蛋白质的转录因子，包括 RPS6KA5/MSK1 和 RPS6KA4/MSK2。P38β Protein, Human (sf9) 是重组的 P38β 蛋白，由 sf9 insect cells 表达，不带标签。

HY-P701731

	P38β Protein, Human (sf9, GST) MAPK11; Mitogen-activated protein Kinase 11; MAP Kinase 11; MAPK 11; Mitogen-activated protein Kinase p38 beta; MAP Kinase p38 beta; p38b; Stress-activated protein Kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	P38β 蛋白 P38β 蛋白是 MAP 激酶通路中重要的丝氨酸/苏氨酸激酶，可响应细胞外刺激，包括促炎细胞因子和身体应激。作为 p38 MAPK 家族的一部分，P38β 直接激活磷酸化许多蛋白质的转录因子，包括 RPS6KA5/MSK1 和 RPS6KA4/MSK2。P38β Protein, Human (sf9, GST) 是重组的 P38β 蛋白，由 sf9 insect cells 表达，带有 N-GST 标签。

HY-P704064

	MAP2K4 Protein, Human (sf9, His, StrepⅡ, GST) Dual specificity mitogen-activated protein Kinase Kinase 4; MAP Kinase Kinase 4; MAPKK 4; JNK-activating Kinase 1; MAPK/ERK Kinase 4 (MEK 4); SAPK/ERK Kinase 1 (SEK1); Stress-activated protein Kinase Kinase 1 (SAPK Kinase 1; SAPKK-1; SAPKK1); c-Jun N-terminal Kinase Kinase 1 (JNKK)	Human	Sf9 insect cells
	MAP2K4 蛋白是参与 MAP 激酶途径的双特异性激酶。MAP2K4 Protein, Human (sf9, His, StrepⅡ, GST) 是重组的 MAP2K4 蛋白，由 Sf9 insect cells 表达，带有 N-His 和 N-GST 和 N-StrepⅡ 标签。

HY-P700592

	MAP2K6 Protein, Human (sf9, His) MAP2K6; mitogen-activated protein Kinase Kinase 6; MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; protein Kinase, mitogen-activated, Kinase 6 (MAP Kinase Kinase 6); EC 2.7.12.2; Dual specificity mitogen-activated protein Kinase Kinase 6; MAP Kinase Kinase 6; MAPK/ERK Kinase 6	Human	Sf9 insect cells
	MAP2K6 蛋白 MKK6 蛋白是参与 MAP 激酶途径的双特异性激酶。MAP2K6 Protein, Human (sf9, His) 是重组的 MAP2K6 蛋白，由 sf9 insect cells 表达，带有 N-6*His 标签。

HY-P701805

	MAPKAPK2 Protein, Human (His) MAPKAPK2; MAP Kinase-activated protein Kinase 2; MAPK-activated protein Kinase 2; MAPKAP Kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	Human	E. coli
	MAPKAPK2 蛋白 MAPKAPK2 蛋白是一种应激激活激酶，参与多种细胞过程，包括细胞因子产生、胞吞作用、细胞骨架重组、细胞迁移、细胞周期控制、染色质重塑、DNA 损伤反应和转录调节。MAPKAPK2 Protein, Human (His) 是重组的 MAPKAPK2 蛋白，由 E. coli 表达，带有 N-6*His 标签和 ΔH217-P237，S216G 突变。

HY-P700589

	MAP2K4 Protein, Human (P. pastoris, His-GST) MAP2K4; mitogen-activated protein Kinase Kinase 4; SERK1; dual specificity mitogen-activated protein Kinase Kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK Kinase 1; MAPK/ERK Kinase 4; SAPK/ERK Kinase 1; MAP Kinase Kinase 4; JNK-activated Kinase 1; JNK activating Kinase 1; JNK-activating Kinase 1; c-Jun N-terminal Kinase Kinase 1; stress-activated protein Kinase Kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1	Human	P. pastoris
	MAP2K4 蛋白 MAP2K4 蛋白是参与 MAP 激酶途径的双特异性激酶。MAP2K4 Protein, Human (P. pastoris, His-GST) 是重组的 MAP2K4 蛋白，由 P. pastoris 表达，带有 N-6*His, N-GST 标签。

HY-P702841

	MAP2K4 Protein, Human (sf9) MAP2K4; mitogen-activated protein Kinase Kinase 4; SERK1; dual specificity mitogen-activated protein Kinase Kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK Kinase 1; MAPK/ERK Kinase 4; SAPK/ERK Kinase 1; MAP Kinase Kinase 4; JNK-activated Kinase 1; JNK activating Kinase 1; JNK-activating Kinase 1; c-Jun N-terminal Kinase Kinase 1; stress-activated protein Kinase Kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1	Human	Sf9 insect cells
	MAP2K4 蛋白 MAP2K4 蛋白是参与 MAP 激酶途径的双特异性激酶。MAP2K4 Protein, Human (sf9) 是重组的 MAP2K4 蛋白，由 sf9 insect cells 表达，不带标签。

HY-P702663

	MAPKAPK3 Protein, Human (Active, sf9, GST) MAPKAPK3; mitogen-activated protein Kinase-activated protein Kinase 3; MAP Kinase-activated protein Kinase 3; 3pK; 3PK; MAPKAP3; MAPKAP Kinase 3; chromosome 3p Kinase; MAPK-activated protein Kinase 3; MK-3; MAPKAP-K3; MAPKAPK-3	Human	Sf9 insect cells
	MAPKAPK3 蛋白 MAPKAPK3 蛋白是一种应激激活激酶，参与多种细胞过程，包括细胞因子产生和内吞作用。它在应激过程中被 p38-alpha/MAPK14 磷酸化，靶向特定底物，与 MAPKAPK2 相似，但活性较低。MAPKAPK3 Protein, Human (Active, sf9, GST) 是重组的 MAPKAPK3 蛋白，由 Sf9 insect cells 表达，带有 GST 标签。

HY-P75223

	MAPK1/ERK2 Protein, Human (sf9, His) Mitogen-activated protein Kinase 1; MAPK 1; ERT1; ERK-2; p42-MAPK	Human	Sf9 insect cells
	MAPK1 蛋白/ERK2 蛋白 ERK2 蛋白是 MAPK/ERK 级联的关键组成部分，调节多种细胞过程，如转录、翻译、有丝分裂、细胞凋亡、内体动力学和高尔基体断裂。通过磷酸化，它调节底物，包括转录因子、细胞骨架元件、细胞凋亡调节因子、翻译调节因子、蛋白激酶和磷酸酶。MAPK1/ERK2 Protein, Human (sf9, His) 是重组的 ERK2 蛋白，由 Sf9 insect cells 表达，带有 C-His 标签。

HY-P76532

	p38 gamma/MAPK12 Protein, Human (sf9) Mitogen-activated protein Kinase 12; Extracellular signal-regulated Kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	p38 gamma 蛋白/MAPK12 蛋白 p38 gamma/MAPK12 蛋白是 MAP 激酶通路中重要的丝氨酸/苏氨酸激酶，可以对促炎细胞因子或应激等细胞外刺激做出反应。p38 MAPK 激活转录因子，例如 ELK1 和 ATF2，每个转录因子可磷酸化大约 200 至 300 个底物。p38 gamma/MAPK12 Protein, Human (sf9) 是重组的 p38 gamma/MAPK12 蛋白，由 Sf9 insect cells 表达，不带标签。

HY-P73334

	p38 delta/MAPK13 Protein, Human (sf9, GST) Mitogen-activated protein Kinase 13; MAPK 13; PRKM13; SAPK4	Human	Sf9 insect cells
	p38 delta 蛋白/MAPK13 蛋白 p38 delta/MAPK13 蛋白是 MAP 激酶途径中重要的丝氨酸/苏氨酸激酶。它协调细胞对细胞因子或应激等刺激的反应，并直接激活转录因子 ELK1 和 ATF2。在该级联中，p38 MAPK（包括 MAPK13）各自磷酸化大约 200 至 300 个底物。p38 delta/MAPK13 Protein, Human (sf9, GST) 是重组的 p38 delta/MAPK13 蛋白，由 Sf9 insect cells 表达，带有 N-GST 标签。

HY-P76533

	p38 gamma/MAPK12 Protein, Human (sf9, His-GST) Mitogen-activated protein Kinase 12; Extracellular signal-regulated Kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	p38 gamma 蛋白/MAPK12 蛋白 p38 gamma/MAPK12 蛋白是 MAP 激酶通路中重要的丝氨酸/苏氨酸激酶，可以对促炎细胞因子或应激等细胞外刺激做出反应。p38 MAPK 激活转录因子，例如 ELK1 和 ATF2，每个转录因子可磷酸化大约 200 至 300 个底物。p38 gamma/MAPK12 Protein, Human (sf9, His-GST) 是重组的 p38 gamma/MAPK12 蛋白，由 Sf9 insect cells 表达，带有 N-His, N-GST 标签。

HY-P73848

	JNK1 Protein, Human (sf9, GST) Mitogen-activated protein Kinase 8; MAPK 8; JNK-46; JNK1; PRKM8	Human	Sf9 insect cells
	JNK1 蛋白 JNK1 是一种多功能丝氨酸/苏氨酸蛋白激酶，复杂地调节多种细胞过程，包括细胞增殖、凋亡和分化。JNK1 由 MAP2K4/MKK4 和 MAP2K7/MKK7 激活，磷酸化 AP-1 成分，并影响转录活性。JNK1 Protein, Human (sf9, GST) 是重组的 JNK1 蛋白，由 Sf9 insect cells 表达，带有 N-GST 标签。

HY-P73335

	p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) Mitogen-activated protein Kinase 14; MAPK 14; CSBP; MXI2; SAPK2A	Human	Sf9 insect cells
	p38 alpha 蛋白/MAPK14 蛋白 p38 α/MAPK14 蛋白是 MAP 激酶途径中重要的丝氨酸/苏氨酸激酶。它可以对细胞因子或应激等刺激做出反应，并直接激活转录因子。在这个级联中，p38 MAPK 每个磷酸化大约 200 至 300 个底物，包括下游激酶 RPS6KA5/MSK1 和 RPS6KA4/MSK2，它们对于立即早期基因诱导至关重要。p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) 是重组的 p38 α/MAPK14 蛋白，由 Sf9 insect cells 表达，带有 N-His 标签。

HY-P701773

	RSK2 Protein, Human RPS6KA3; Ribosomal protein S6 Kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 Kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein Kinase 1; ISPK-1; MAP Kinase-activated protein Kinase 1b; MAPK-activated protein Kinase 1b; MAPKAP Kinase 1b; MAPKAPK-1b; Ribosomal S6 Kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 蛋白 RSK2 是 ERK 信号传导下游的激酶，在介导有丝分裂和应激反应中发挥着关键作用。它激活转录因子（CREB1、ETV1、NR4A1），影响增殖、存活和分化。RSK2 Protein, Human 是重组的 RSK2 蛋白，由 E. coli 表达，不带标签。

HY-P701774

	RSK2 Protein, Human (His) RPS6KA3; Ribosomal protein S6 Kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 Kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein Kinase 1; ISPK-1; MAP Kinase-activated protein Kinase 1b; MAPK-activated protein Kinase 1b; MAPKAP Kinase 1b; MAPKAPK-1b; Ribosomal S6 Kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 蛋白 RSK2 是 ERK 信号传导下游的激酶，在介导有丝分裂和应激反应中发挥着关键作用。它激活转录因子（CREB1、ETV1、NR4A1），影响增殖、存活和分化。RSK2 Protein, Human (His) 是重组的 RSK2 蛋白，由 E. coli 表达，带有 N-6*His 标签。

HY-P701771

	RSK1 Protein, Human (sf9) RPS6KA1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAPK-1a; Ribosomal S6 Kinase 1; RSK-1	Human	Sf9 insect cells
	RSK1 蛋白 RSK1 是 ERK 信号传导下游的激酶，对于有丝分裂和应激诱导的反应至关重要。它激活转录因子（CREB1、ETV1、NR4A1），影响增殖、存活和分化。RSK1 Protein, Human (sf9) 是重组的 RSK1 蛋白，由 sf9 insect cells 表达，不带标签。

HY-P701772

	RSK1 Protein, Human (sf9, His) RPS6KA1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAPK-1a; Ribosomal S6 Kinase 1; RSK-1	Human	Sf9 insect cells
	RSK1 蛋白 RSK1 是 ERK 信号传导下游的激酶，对于有丝分裂和应激诱导的反应至关重要。它激活转录因子（CREB1、ETV1、NR4A1），影响增殖、存活和分化。RSK1 Protein, Human (sf9, His) 是重组的 RSK1 蛋白，由 sf9 insect cells 表达，带有 N-8*His 标签。

HY-P702664

	MAPKAPK5 Protein, Human (sf9, GST) MAPKAPK5; MAPK activated protein Kinase 5; MK5; MK-5; NCFD; PRAK; MAPKAP-K5	Human	Sf9 insect cells
	MAPKAPK5 蛋白 MAPKAPK5 Protein, Human (sf9, GST) 是重组的 MAPKAPK5 蛋白，由 Sf9 insect cells 表达，带有 GST 标签。MAPKAPK5 Protein, Human (sf9, GST)

HY-P70931

	MAPKSP1 Protein, Human (His) Ragulator Complex Protein LAMTOR3; Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3; MEK-Binding Partner 1; Mp1; Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1; Mitogen-Activated Protein Kinase Scaffold Protein 1; LAMTOR3; MAP2K1IP	Human	E. coli
	MAPKSP1 蛋白 MAPKSP1 蛋白，也称为胆色素原脱氨酶 (HMBS)，在血红素生物合成途径中至关重要，可催化四个胆色素原分子顺序聚合形成羟甲基双烷。该过程始于胆色素原或前尿卟啉原的二吡咯甲烷辅助因子的组装。MAPKSP1 Protein, Human (His) 是重组的 MAPKSP1 蛋白，由 E. coli 表达，带有 N-6*His 标签。

HY-P70921

	MBIP Protein, Human (His) MAP3K12-Binding Inhibitory Protein 1; MAPK Upstream Kinase-Binding Inhibitory Protein; MUK-Binding Inhibitory Protein; MBIP	Human	E. coli
	MBIP 蛋白 MBIP 蛋白抑制 MAP3K12 活性并阻止 JNK/SAPK 通路的激活。它是 ATAC 复合体的重要组成部分，ATAC 复合体是一种针对组蛋白 H3 和 H4 的组蛋白乙酰转移酶复合体。MBIP Protein, Human (His) 是重组的 MBIP 蛋白，由 E. coli 表达，带有 N-6*His 标签。

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Cat. No.	Product Name	Chemical Structure

HY-121605S

RL71-d6

RL71-d₆ 是氘代标记的 RL71 (HY-121605)。RL71 是一种姜黄素类抗癌剂，对多种 ER 阴性乳腺癌细胞表现出强烈的细胞毒性。RL71 (1 μM) 能诱导细胞周期在 G2/M 期停滞，并诱导 SKBr3 细胞中凋亡。RL7 还降低 HER2/neu 的磷酸化并增加了 p27。RL71 还显著降低了 Akt 的磷酸化并短暂增加了应激激酶 JNK1/2 和 p38 MAPK。此外，RL71 在体外表现出抗血管生成潜力，抑制 HUVEC 细胞的迁移以及这些细胞形成管状网络的能力。

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80393

	ERK1/2 Antibody (YA453) 3 篇文献验证 MAP Kinase 3; MAPK 3; ERK-1; p44-MAPK; MAP Kinase 1; MAPK 1; ERK-2; p42-MAPK	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	ERK1/2 Antibody (YA453) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

HY-P85835

	ERK2 Antibody (YA5527) MAPK1; ERK2; PRKM1; PRKM2; Mitogen-activated protein Kinase 1; MAP Kinase 1; MAPK 1; ERT1; Extracellular signal-regulated Kinase 2; ERK-2; MAP Kinase isoform p42; p42-MAPK; Mitogen-activated protein Kinase 2; MAP Kinase 2; MAPK 2	WB, ICC/IF, ELISA	Human, Mouse, Rat
	ERK2 Antibody (YA5527) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ERK2.

HY-P85152

	MAPK6/ERK3 Antibody (YA4844) MAPK6; ERK3; PRKM6; Mitogen-activated protein Kinase 6; MAP Kinase 6; MAPK 6; Extracellular signal-regulated Kinase 3; ERK-3; MAP Kinase isoform p97; p97-MAPK	WB, FC, ELISA	Human
	MAPK6/ERK3 Antibody (YA4844) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAPK6/ERK3.

HY-P86354

	ERK5 Antibody (YA6046) MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein Kinase 7; MAP Kinase 7; MAPK 7; Big MAP Kinase 1; BMK-1; Extracellular signal-regulated Kinase 5; ERK-5	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ERK5 Antibody (YA6046) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK5.

HY-P86387

	ERK1/2 Antibody (YA6079) MAPK3; ERK1; PRKM3; Mitogen-activated protein Kinase 3; MAP Kinase 3; MAPK 3; ERT2; Extracellular signal-regulated Kinase 1; ERK-1; Insulin-stimulated MAP2 Kinase; MAP Kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 Kinase; p	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ERK1/2 Antibody (YA6079) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

HY-P82888

	MEKK3 Antibody (YA2633) MAP/ERK Kinase Kinase 3; MAP3K3; MAPK/ERK Kinase Kinase 3; MAPKKK3; MEK Kinase 3; MEKK 3; MEKK3; Mitogen activated protein Kinase Kinase Kinase 3	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MEKK3 Antibody (YA2633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEKK3.

HY-P81378

	MAP4K4/NIK Antibody (YA1123) MAP4K4; HGK, KIAA0687, NIK; Mitogen-activated protein Kinase Kinase Kinase Kinase 4; HPK/GCK-like Kinase HGK; MAPK/ERK Kinase Kinase Kinase 4 (MEK Kinase Kinase 4; MEKKK 4); Nck-interacting Kinase	IHC-P	Human
	MAP4K4/NIK Antibody (YA1123) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAP4K4/NIK.

HY-P86654

	ERK1/2 Antibody (YA6346) ERK1+ERK2; ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated Kinase 1; Extracellular signal regulated Kinase 2; Extracellular signal-regulated Kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 Kinase; MAP Kinase 1; MAP Kinase 2; MAP Kinase isoform p42; MAP Kinase isoform p44; MAPK 1; MAPK 2; MAPK 3; MAPK1; MAPK2; MAPK3; MGC20180; Microtubule associated protein 2 Kinase; Mitogen activated protein Kinase 1; Mitogen activated protein Kinase 2; Mitogen activated protein Kinase 3; Mitogen-activated protein Kinase 1; Mitogen-activated protein Kinase 2; MK01_HUMAN; MK03_HUMAN; p38; p40; p41; p41MAPK; p42 MAPK; p42-MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44MAPK; PRKM 1; PRKM 2; PRKM 3; PRKM1; PRKM2; PRKM3; Protein Kinase mitogen activated 1; Protein Kinase mitogen activated 2; Protein Kinase mitogen activated 3; Protein tyrosine Kinase ERK 2.	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	ERK1/2 Antibody (YA6346) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

HY-P85200

	MAP4K4/NIK Antibody (YA4892) MAP4K4; HGK; KIAA0687; NIK; Mitogen-activated protein Kinase Kinase Kinase Kinase 4; HPK/GCK-like Kinase HGK; MAPK/ERK Kinase Kinase Kinase 4; MEK Kinase Kinase 4; MEKKK 4; Nck-interacting Kinase	WB, ELISA	Human
	MAP4K4/NIK Antibody (YA4892) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAP4K4/NIK.

HY-P80214

	MAPKAPK2 Antibody (YA304) MAP Kinase activated protein Kinase 2 antibody; MAP Kinase-activated protein Kinase 2 antibody; MAPK activated protein Kinase 2 antibody; MAPK-activated protein Kinase 2 antibody; MAPK2_HUMAN antibody; MAPKAP K2 antibody; MAPKAP Kinase 2 antibody; MAPKAPK 2 antibody; MAPKAPK-2 antibody; MAPKAPK2 antibody; Mitogen activated protein Kinase activated protein Kinase 2 antibody; MK 2 antibody; MK2 antibody	WB, IP	Human, Mouse, Rat
	MAPKAPK2 Antibody (YA304) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAPKAPK2.

HY-P83470

	MEKK2 Antibody (YA3215) MAP3K2; MAPKKK2; MEKK2; Mitogen-activated protein Kinase Kinase Kinase 2; MAPK/ERK Kinase Kinase 2; MEK Kinase 2; MEKK 2	WB, ICC/IF, IP	Human, Mouse, Rat
	MEKK2 Antibody (YA3215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEKK2.

HY-P85273

	MEKK2 Antibody (YA4965) MAP3K2; MAPKKK2; MEKK2; Mitogen-activated protein Kinase Kinase Kinase 2; MAPK/ERK Kinase Kinase 2; MEK Kinase 2; MEKK 2	WB, ICC/IF, ELISA	Human
	MEKK2 Antibody (YA4965) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEKK2.

HY-P86225

	Phospho-Erk 1/2(Thr202/Tyr204) Antibody (YA5917) MAPK3; ERK1; PRKM3; Mitogen-activated protein Kinase 3; MAP Kinase 3; MAPK 3; ERT2; Extracellular signal-regulated Kinase 1; ERK-1; Insulin-stimulated MAP2 Kinase; MAP Kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 Kinase; p	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Erk 1/2(Thr202/Tyr204) Antibody (YA5917) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Erk 1/2(Thr202/Tyr204).

HY-P83325

	MAPKAP Kinase 3 Antibody (YA3070) MAPKAPK3; MAP Kinase-activated protein Kinase 3; MAPK-activated protein Kinase 3; MAPKAP Kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3; Chromosome 3p Kinase; 3pK	WB, IP	Human
	MAPKAP Kinase 3 Antibody (YA3070) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAPKAP Kinase 3.

HY-P85717

	JNK2 Antibody (YA5409) Mitogen-activated protein Kinase 9; MAP Kinase 9; MAPK 9; JNK-55; Stress-activated protein Kinase 1a; SAPK1a; Stress-activated protein Kinase JNK2; c-Jun N-terminal Kinase 2;	IHC-P	Human, Mouse, Rat
	JNK2 Antibody (YA5409) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JNK2.

HY-P80549

	ASK1 Antibody MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein Kinase Kinase Kinase 5; Apoptosis signal-regulating Kinase 1; ASK-1; MAPK/ERK Kinase Kinase 5; MEK Kinase 5; MEKK 5	WB, IHC-P, ICC/IF, FC	Human, Mouse
	ASK1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ASK1.

HY-P86106

	JNK2 Antibody (YA5798) MAPK9; JNK2; PRKM9; SAPK1A; Mitogen-activated protein Kinase 9; MAP Kinase 9; MAPK 9; JNK-55; Stress-activated protein Kinase 1a; SAPK1a; Stress-activated protein Kinase JNK2; c-Jun N-terminal Kinase 2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	JNK2 Antibody (YA5798) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JNK2.

HY-P83469

	MEK3 Antibody (YA3214) AW212142; dual specificity mitogen activated protein Kinase Kinase 3; Dual specificity mitogen activated protein Kinase Kinase 6; Dual specificity mitogen-activated protein Kinase Kinase 3; MAP Kinase Kinase 3; MAP Kinase Kinase 6; map2k3; MAP2K6; MAPK ERK Kinase 3; MAPK/ERK Kinase 3; MAPK/ERK Kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK 3; MEK 6; MEK3; Mitogen activated protein Kinase Kinase 3; Mitogen activated protein Kinase Kinase 6; MKK 3; MKK3; MKK6; mMKK3b; MP2K3_HUMAN; PRKMK 3; PRKMK3; PRKMK6; Protein Kinase; mitogen activated; Kinase 6 (MAP Kinase Kinase 6); protein Kinase; mitogen-activated; Kinase 3; SAPK Kinase 2; SAPKK 2; SAPKK 3; SAPKK-2; SAPKK2; SAPKK3; Stress activated protein Kinase Kinase 2; Stress activated protein Kinase Kinase 3; Stress-activated protein Kinase Kinase 2.	WB, ICC/IF, IP	Human, Mouse, Rat
	MEK3 Antibody (YA3214) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3.

HY-P85783

	Kininogen 1 Antibody (YA5475) Dual specificity mitogen-activated protein Kinase Kinase 5; MAP Kinase Kinase 5; MAPKK 5; MAPK/ERK Kinase 5; MEK 5;	WB	Human, Mouse, Rat
	Kininogen 1 Antibody (YA5475) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Kininogen 1.

HY-P85237

	JNK3 Antibody (YA4929) MAPK10; JNK3; JNK3A; PRKM10; SAPK1B; Mitogen-activated protein Kinase 10; MAP Kinase 10; MAPK 10; MAP Kinase p49 3F12; Stress-activated protein Kinase 1b; SAPK1b; Stress-activated protein Kinase JNK3; c-Jun N-terminal Kinase 3	WB, ICC/IF, ELISA	Human, Mouse
	JNK3 Antibody (YA4929) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JNK3.

HY-P85046

	ASK1 Antibody (YA4738) MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein Kinase Kinase Kinase 5; Apoptosis signal-regulating Kinase 1; ASK-1; MAPK/ERK Kinase Kinase 5; MEK Kinase 5; MEKK 5	WB, IHC-P, ICC/IF, FC, ELISA	Human
	ASK1 Antibody (YA4738) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ASK1.

HY-P86322

	ASK1 Antibody (YA6014) MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein Kinase Kinase Kinase 5; Apoptosis signal-regulating Kinase 1; ASK-1; MAPK/ERK Kinase Kinase 5; MEK Kinase 5; MEKK 5	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	ASK1 Antibody (YA6014) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ASK1.

HY-P80792

	Phospho-ASK1 (Ser966) Antibody MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein Kinase Kinase Kinase 5; Apoptosis signal-regulating Kinase 1; ASK-1; MAPK/ERK Kinase Kinase 5; MEK Kinase 5; MEKK 5	WB, IHC-P	Human, Mouse, Rat
	Phospho-ASK1 (Ser966) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-ASK1 (Ser966).

HY-P86156

	MAPKAPK2 Antibody (YA5848) MAPKAPK2; MAP Kinase-activated protein Kinase 2; MAPK-activated protein Kinase 2; MAPKAP Kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MAPKAPK2 Antibody (YA5848) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAPKAPK2.

HY-P83405

	JNK3 Antibody (YA3150) Mitogen-activated protein Kinase 10; MAP Kinase 10; MAPK 10; MAP Kinase p49 3F12; Stress-activated protein Kinase 1b; SAPK1b; MAPK10; JNK3; JNK3A; PRKM10; SAPK1B	WB, ICC/IF, FC	Human, Mouse, Rat
	JNK3 Antibody (YA3150) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JNK3.

HY-P87386

	p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069) ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated Kinase 6 antibody; MAP Kinase 12 antibody; MAP Kinase p38 gamma antibody; MAPK 12 antibody; MAPK12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein Kinase p38 gamma antibody	WB	Human, Mouse, Rat, Monkey
	p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13.

HY-P85516

	MEK1 Antibody (YA5208) AA589381; Dual specificity mitogen-activated protein Kinase Kinase 1; Dual specificity mitogen-activated protein Kinase Kinase 2; ERK activator Kinase 1; ERK activator Kinase 2; FLJ26075; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP2K1; MAP2K2; MAPK/ERK Kinase 1; MAPK/ERK Kinase 2; MAPKK 1; MAPKK1; MAPKK2; MEK 1; MEKK1; Mitogen activated protein Kinase Kinase 1; Mitogen activated protein Kinase Kinase 2; Mitogen-activated protein Kinase Kinase 2, p45; MK2; MKK 1; MKK 2; MKK1; MKK2; MP2K1_HUMAN; PRKMK 1; PRKMK 2; Prkmk1; Prkmk2; protein Kinase, mitogen-activated, Kinase 1; MAP Kinase Kinase 1; Protein Kinase, mitogen-activated, Kinase 1; Protein Kinase, mitogen-activated, Kinase 2.	WB	Human
	MEK1 Antibody (YA5208) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK1.

HY-P83774

	Phospho-MAPKAPK2 (Thr334) Antibody MAPKAPK2; MAP Kinase-activated protein Kinase 2; MAPK-activated protein Kinase 2; MAPKAP Kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-MAPKAPK2 (Thr334) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-MAPKAPK2 (Thr334).

HY-P87165

	p38 gamma/MAPK12 Antibody (YA6858) ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated Kinase 6 antibody; MAP Kinase 12 antibody; MAP Kinase p38 gamma antibody; MAPK 12 antibody; MAPK12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein Kinase p38 gamma antibody; ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated Kinase 6 antibody; MAP Kinase 12 antibody; MAP Kinase p38 gamma antibody; MAPK 12 antibody; MAPK12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein Kinase p38 gamma antibody; Mitogen-activated protein Kinase 12 antibody; Mitogen-activated protein Kinase p38 gamma antibody; MK12_HUMAN antibody; P38 GAMMA antibody; P38GAMMA antibody; PRKM12 antibody; SAPK 3 antibody; SAPK-3 antibody; SAPK3 antibody; Stress Activated Protein Kinase 3 antibody; Stress-activated protein Kinase 3 antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	p38 gamma/MAPK12 Antibody (YA6858) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 gamma/MAPK12.

HY-P82902

	MEK7 Antibody (YA2647) MAP2K7; JNKK2; MEK7; MKK7; PRKMK7; SKK4; Dual specificity mitogen-activated protein Kinase Kinase 7; MAP Kinase Kinase 7; MAPKK 7; JNK-activating Kinase 2; MAPK/ERK Kinase 7; MEK 7; Stress-activated protein Kinase Kinase 4; SAPK Kinase 4; S	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MEK7 Antibody (YA2647) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK7.

HY-P83314

	MEK2 Antibody (YA3059) MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein Kinase Kinase 2; MAP Kinase Kinase 2; MAPKK 2; ERK activator Kinase 2; MAPK/ERK Kinase 2; MEK 2	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	MEK2 Antibody (YA3059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK2.

HY-P85274

	MEK2 Antibody (YA4966) MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein Kinase Kinase 2; MAP Kinase Kinase 2; MAPKK 2; ERK activator Kinase 2; MAPK/ERK Kinase 2; MEK 2	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat
	MEK2 Antibody (YA4966) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK2.

HY-P85739

	MEK2 Antibody (YA5431) MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein Kinase Kinase 2; MAP Kinase Kinase 2; MAPKK 2; ERK activator Kinase 2; MAPK/ERK Kinase 2; MEK 2	WB	Human, Rat, Mouse
	MEK2 Antibody (YA5431) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK2.

HY-P86470

	MEK1 Antibody (YA6162) MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein Kinase Kinase 1; MAP Kinase Kinase 1; MAPKK 1; MKK1; ERK activator Kinase 1; MAPK/ERK Kinase 1; MEK 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK1 Antibody (YA6162) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK1.

HY-P86251

	JNK1/2/3 Antibody (YA5943) MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein Kinase 8; MAP Kinase 8; MAPK 8; JNK-46; Stress-activated protein Kinase 1c; SAPK1c; Stress-activated protein Kinase JNK1; c-Jun N-terminal Kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	JNK1/2/3 Antibody (YA5943) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JNK1/2/3.

HY-P85311

	p38β Antibody (YA5003) MAPK11; PRKM11; SAPK2; SAPK2B; Mitogen-activated protein Kinase 11; MAP Kinase 11; MAPK 11; Mitogen-activated protein Kinase p38 beta; MAP Kinase p38 beta; p38b; Stress-activated protein Kinase 2b; SAPK2b; p38-2	WB, ELISA	Human
	p38β Antibody (YA5003) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to p38β.

HY-P81343

	MAP2K6 Antibody (YA1088) MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein Kinase Kinase 6; MAP Kinase Kinase 6; MAPKK 6; MAPK/ERK Kinase 6; MEK 6; Stress-activated protein Kinase Kinase 3; SAPK Kinase 3; SAPKK-3; SAPKK3	WB, IP	Human, Rat
	MAP2K6 Antibody (YA1088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP2K6.

HY-P85276

	MAP2K6 Antibody (YA4968) MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein Kinase Kinase 6; MAP Kinase Kinase 6; MAPKK 6; MAPK/ERK Kinase 6; MEK 6; Stress-activated protein Kinase Kinase 3; SAPK Kinase 3; SAPKK-3; SAPKK3	WB, ICC/IF, FC, ELISA	Human, Mouse
	MAP2K6 Antibody (YA4968) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAP2K6.

HY-P86356

	MEK3 Antibody (YA6048) MAP2K3; MEK3; MKK3; PRKMK3; SKK2; Dual specificity mitogen-activated protein Kinase Kinase 3; MAP Kinase Kinase 3; MAPKK 3; MAPK/ERK Kinase 3; MEK 3; Stress-activated protein Kinase Kinase 2; SAPK Kinase 2; SAPKK-2; SAPKK2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK3 Antibody (YA6048) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3.

HY-P83395

	MEK5 Antibody (YA3140) MAP2K5; MEK5; MKK5; PRKMK5; Dual specificity mitogen-activated protein Kinase Kinase 5; MAP Kinase Kinase 5; MAPKK 5; MAPK/ERK Kinase 5; MEK 5	WB, ICC/IF	Human
	MEK5 Antibody (YA3140) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK5.

HY-P85333

	MAPKAPK5 Antibody (YA5025) MAPKAPK5; PRAK; MAP Kinase-activated protein Kinase 5; MAPK-activated protein Kinase 5; MAPKAP Kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein Kinase; PRAK	WB, IHC-P, ICC/IF, ELISA	Human
	MAPKAPK5 Antibody (YA5025) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAPKAPK5.

HY-P85712

	p38 alpha/MAPK14 Antibody (YA5404) Mitogen-activated protein Kinase 14; MAP Kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP Kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein Kinase p38 alpha; MAP Kinase p38 alpha; Stress-activated protein Kinase 2a; SAPK2a;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	p38 alpha/MAPK14 Antibody (YA5404) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P86460

	p38 alpha/MAPK14 Antibody (YA6152) Mitogen-activated protein Kinase 14; MAP Kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP Kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein Kinase p38 alpha; MAP Kinase p38 alpha; Stress-activated protein Kinase 2a; SAPK2a;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	p38 alpha/MAPK14 Antibody (YA6152) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P80832

	Phospho-MEK1 (Ser298) Antibody (YA178) 1 篇文献验证 MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein Kinase Kinase 1; MAP Kinase Kinase 1; MAPKK 1; MKK1; ERK activator Kinase 1; MAPK/ERK Kinase 1; MEK 1	WB, ICC/IF	Human, Mouse, Rat
	Phospho-MEK1 (Ser298) Antibody (YA178) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MEK1 (Ser298).

HY-P80833

	Phospho-MEK1 (Thr292) Antibody (YA177) MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein Kinase Kinase 1; MAP Kinase Kinase 1; MAPKK 1; MKK1; ERK activator Kinase 1; MAPK/ERK Kinase 1; MEK 1	WB	Mouse, Rat
	Phospho-MEK1 (Thr292) Antibody (YA177) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MEK1 (Thr292).

HY-P86863

	ERK8 Antibody (YA6556) ERK 7 antibody; ERK 8 antibody; ERK-7 antibody; ERK-8 antibody; ERK7 antibody; ERK8 antibody; Extracellular regulated Kinase 8 delta antibody; Extracellular signal regulated Kinase 8 antibody; Extracellular signal-regulated Kinase 7 antibody; Extracellular signal-regulated Kinase 8 antibody; ERK 7 antibody; ERK 8 antibody; ERK-7 antibody; ERK-8 antibody; ERK7 antibody; ERK8 antibody; Extracellular regulated Kinase 8 delta antibody; Extracellular signal regulated Kinase 8 antibody; Extracellular signal-regulated Kinase 7 antibody; Extracellular signal-regulated Kinase 8 antibody; MAP Kinase 15 antibody; MAPK 15 antibody; MAPK15 antibody; Mitogen activated protein Kinase 15 antibody; Mitogen-activated protein Kinase 15 antibody; MK15_HUMAN antibody;	WB, IHC-P	Human, Mouse, Rat
	ERK8 Antibody (YA6556) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK8.

HY-P85275

	MEK4 Antibody (YA4967) MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein Kinase Kinase 4; MAP Kinase Kinase 4; MAPKK 4; JNK-activating Kinase 1; MAPK/ERK Kinase 4; MEK 4; SAPK/ERK Kinase 1; SEK1; Stress-activated pro	WB, IHC-P, ICC/IF, FC, ELISA	Human
	MEK4 Antibody (YA4967) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK4.

HY-P86344

	MEK4 Antibody (YA6036) MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein Kinase Kinase 4; MAP Kinase Kinase 4; MAPKK 4; JNK-activating Kinase 1; MAPK/ERK Kinase 4; MEK 4; SAPK/ERK Kinase 1; SEK1; Stress-activated pro	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK4 Antibody (YA6036) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK4.

HY-P80776

	p38 alpha/MAPK14 Antibody (YA696) 2 篇文献验证 MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein Kinase 14; MAP Kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP Kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat, Monkey
	p38 alpha/MAPK14 Antibody (YA696) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P80777

	p38 alpha/MAPK14 Antibody (YA252) MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein Kinase 14; MAP Kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP Kinase MXI2; MAX-interacting protein	WB, IP	Human
	p38 alpha/MAPK14 Antibody (YA252) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 alpha/MAPK14.

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Cat. No.	Product Name		Classification

HY-W355700

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine		磷脂
1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) 是一种参与磷脂代谢的溶血磷脂酰乙醇胺分子，靶向细胞膜受体 (如 G 蛋白偶联受体) 而调节细胞信号通路。1-oleoyl-sn-glycero-3-phosphoethanolamine 可能激活丝裂原活化蛋白激酶 (MAPK) 信号，促进细胞迁移、调节炎症反应及脂质代谢，兼具促炎与抗炎双重活性。1-oleoyl-sn-glycero-3-phosphoethanolamine 主要应用于代谢性疾病 (如非酒精性脂肪性肝病、肥胖) 的生物标志物筛选，以及溶血磷脂在细胞膜稳态和信号传导中的机制研究。

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