2. Neuronal Signaling PI3K/Akt/mTOR NF-κB
  3. Cholinesterase (ChE) PI3K Akt NF-κB
  4. Skimmianine

Skimmianine  (Synonyms: 茵芋碱)

目录号: HY-N2081 纯度: 99.90%
COA 产品使用指南 技术支持

Skimmianine 是一种口服有效的呋喃喹啉生物碱，主要存在于芸香科。Skimmianine 具有镇痛、解痉、镇静和抗炎作用。Skimmianine 抑制乙酰胆碱酯酶 (AChE) (IC50 = 8.6 μg/mL)。Skimmianine 具有细胞毒性，并具有遗传毒性。Skimmianine 对缺血-再灌注 (IR) 损伤具有抗氧化和抗炎作用。Skimmianine 通过激活磷脂酰肌醇-3-激酶 (PI3K)-蛋白激酶 B (AKT) 通路发挥抗炎作用。Skimmianine 通过靶向 NF-κB 活化通路来预防神经炎症，从而发挥神经保护作用。Skimmianine 可抑制组胺的释放、细胞内 Ca2+ 信号传导和蛋白激酶 C 信号传导。

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Skimmianine Chemical Structure

Skimmianine Chemical Structure

CAS No. : 83-95-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1996
In-stock
1 mg ￥560
In-stock
5 mg ￥1400
In-stock
10 mg ￥2240
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Skimmianine:

Skimmianine 相关抗体

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca2+ signaling and protein kinase C signaling[1][2][3][4].

IC50 & Target[4]

AChE

8.6 μg/mL (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 8
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 18950230]
Neutrophil IC50
35.5 μM
Compound: 8
Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of luminol-induced oxidative burst by chemiluminescence assay
Immunomodulatory activity in polymorphoneutrophils assessed as inhibition of luminol-induced oxidative burst by chemiluminescence assay
[PMID: 18950230]
体外研究
(In Vitro)

Skimmianine (Compound 1) (1 μg) 在 Z. nitidum 的生物碱提取物中，具有显著的 AChE 抑制活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Skimmianine 相关抗体:
体内研究
(In Vivo)

Skimmianine (20 mg/kg，口服，单剂量) 可引起雄性 SD 大鼠代谢物中氧的加成反应[1]。
Skimmianine (40 mg/kg，口服，单剂量) 可降低雌性 Wistar 白化大鼠的 MDA 水平，并提高 SOD 和 CAT 活性[2]。
Skimmianine (1-10 mg/kg，腹腔注射，单剂量) 在 5 mg/kg 剂量下可抑制 82% 的水肿，其中 5 mg/kg 是雄性 Wistar 大鼠最大水肿抑制的最低浓度[3]。
Skimmianine (5 mg/kg，腹腔注射，单剂量) 与 Carrageenan (Carr) (HY-125474) 相比，可显著降低 PGE2 浓度，与雄性 Wistar 大鼠的 Diclofenac (Dic) (HY-15036) 组相比，下降幅度不显著[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 24 female Wistar albino rats[2]
Dosage: 40 mg/kg
Administration: Oral gavage (p.o.) single dose
Result: Significantly downregulated the expression of IBA-1 in cerebral tissues.
Downregulated the expression of IL-6 in cells in both white and gray matter.
Prevented the activation of NF-κB in neurons and glial cells, lowering NF-κB expression.
Significantly decreases NF-κB immune reactivity in cerebral tissues.
Animal Model: Adult male Wistar rats (140-160 g)[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.) single dose
Result: Showed a significant decrease when Skimmianine used as a pre-treatment.
Showed a significant decrease in the level of TBARS when combined with Carr compared to Carr alone.
Showed a significant reduction in TNF-α and IL-6 mRNA levels when combined with Carr.
分子量

259.26

同用名

茵芋碱

Formula

C14H13NO4
CAS 号
性状

固体

颜色

White to off-white

中文名称

茵芋碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 33.33 mg/mL (128.56 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8571 mL 19.2857 mL 38.5713 mL
5 mM 0.7714 mL 3.8571 mL 7.7143 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.90%

COA (290 KB) HNMR (242 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

Skimmianine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8571 mL 19.2857 mL 38.5713 mL 96.4283 mL
5 mM 0.7714 mL 3.8571 mL 7.7143 mL 19.2857 mL
10 mM 0.3857 mL 1.9286 mL 3.8571 mL 9.6428 mL
15 mM 0.2571 mL 1.2857 mL 2.5714 mL 6.4286 mL
20 mM 0.1929 mL 0.9643 mL 1.9286 mL 4.8214 mL
25 mM 0.1543 mL 0.7714 mL 1.5429 mL 3.8571 mL
30 mM 0.1286 mL 0.6429 mL 1.2857 mL 3.2143 mL
40 mM 0.0964 mL 0.4821 mL 0.9643 mL 2.4107 mL
50 mM 0.0771 mL 0.3857 mL 0.7714 mL 1.9286 mL
60 mM 0.0643 mL 0.3214 mL 0.6429 mL 1.6071 mL
80 mM 0.0482 mL 0.2411 mL 0.4821 mL 1.2054 mL
100 mM 0.0386 mL 0.1929 mL 0.3857 mL 0.9643 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Skimmianine83-95-4茵芋碱Cholinesterase (ChE)PI3KAktNF-κBPhosphoinositide 3-kinasePKBProtein kinase BNuclear factor-κBNuclear factor-kappaBanalgesicantispasticsedativeantiplateletaggregationgenotoxicityInhibitorinhibitorinhibit

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