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  2. Kras - Kirsten rat sarcoma viral oncogene homolog Gene

Kras - Kirsten rat sarcoma viral oncogene homolog Gene

中文名称:Kirsten 大鼠肉瘤病毒癌基因同系物

种属: Mus musculus

同用名: ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras

基因 ID: 16653 | 基因类型: protein coding

关于 Kras

Chromosome 6: 145,162,425-145,195,965 reverse strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 201 orthologues, 35 paralogues and is associated with 90 phenotypes. Ubiquitous expression in CNS E18 (RPKM 17.), whole brain E14.5 (RPKM 16.2) and 26 other tissues.


该基因编码的蛋白可启动 GTPase 活动。参与内分泌信号。作用于几个过程的上游或内部,包括前脑星形胶质细胞发育;化学突触传递的调节;和 Rac 蛋白信号转导的正调控。位于膜内。以多种结构表达,包括大脑;早期胚胎;眼睛;泌尿生殖系统;和直觉。用于研究多种疾病,包括努南综合征 3;癌(多发性);幼年型粒单核细胞白血病;肺癌;和前列腺癌。该基因的人类直系同源物与多种疾病有关,包括努南综合征(多种);脑动静脉畸形;心面皮肤综合征(多发性);胃肠系统癌症(多发性);和血液系统癌症(多种)。与人类 KRAS 同源(KRAS 原癌基因,GTPase)。 [由基因组资源联盟提供,2022 年 4 月]

Enables GTPase activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate Cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Kras 基因产物(8)

mRNA Protein Name
NM_001403242.1 NP_001390171.1 GTPase KRas isoform 1
NM_001403245.1 NP_001390174.1 GTPase KRas isoform 3
NM_001403241.1 NP_001390170.1 GTPase KRas isoform 1
NM_001403246.1 NP_001390175.1 GTPase KRas isoform 4
NM_021284.7 NP_067259.4 GTPase KRas isoform 1
NM_001403243.1 NP_001390172.1 GTPase KRas isoform 2
NM_001403240.1 NP_001390169.1 GTPase KRas isoform 1
NM_001403244.1 NP_001390173.1 GTPase KRas isoform 3

Kras 蛋白结构


H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 188 a.a.
蛋白主名 其他名称

GTPase KRas

Kirsten rat sarcoma oncogene 2, expressed

p21 protein

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog


种属 基因名 来源 基因 ID
Homo sapiens Kras NCBI NCBI:3845