2. Gene
  3. Th - tyrosine hydroxylase Gene

Th - tyrosine hydroxylase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: The

基因 ID: 25085 | 基因类型: protein coding

关于 Th

功能概要

Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; hypoglycemia; polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (Tyrosine Hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Th 基因产物(1)

mRNA Protein Name
NM_012740.4 NP_036872.1 tyrosine 3-monooxygenase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amino acid binding IDA
IDA: 通过直接分析推断
19489646 RGD
enables amino acid binding IPI
IPI: 通过物理相互作用推断
15639226 RGD
enables dopamine binding IPI
IPI: 通过物理相互作用推断
15639226 RGD
enables ferric iron binding IDA
IDA: 通过直接分析推断
16475826 RGD
enables ferrous iron binding IDA
IDA: 通过直接分析推断
16475826 RGD
enables monooxygenase activity IDA
IDA: 通过直接分析推断
33381 RGD
enables oxygen binding IDA
IDA: 通过直接分析推断
19489646 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11943812 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
19903816 RGD
enables small molecule binding EXP
EXP: 通过实验结果推断
19371093 RGD
enables small molecule binding IDA
IDA: 通过直接分析推断
10375411 RGD
enables tetrahydrobiopterin binding IDA
IDA: 通过直接分析推断
19489646 RGD
enables tyrosine 3-monooxygenase activity IDA
IDA: 通过直接分析推断
19489646 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aminergic neurotransmitter loading into synaptic vesicle IDA
IDA: 通过直接分析推断
19903816 RGD
involved in catecholamine biosynthetic process IDA
IDA: 通过直接分析推断
20025246 RGD
involved in cellular response to alkaloid IEP
IEP: 通过表达模式推断
18696327 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
21217063 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
17306206 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
19781568 RGD
involved in cellular response to nicotine IEP
IEP: 通过表达模式推断
20827341 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18602388 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
21295554 RGD
involved in circadian sleep/wake cycle IEP
IEP: 通过表达模式推断
20980612 RGD
involved in cognition IEP
IEP: 通过表达模式推断
20096955 RGD
involved in dopamine biosynthetic process from tyrosine IDA
IDA: 通过直接分析推断
2427363 RGD
involved in dopamine biosynthetic process from tyrosine IMP
IMP: 通过突变表型推断
11943812 RGD
involved in fatty acid metabolic process IEP
IEP: 通过表达模式推断
21071351 RGD
involved in glycoside metabolic process IEP
IEP: 通过表达模式推断
20183248 RGD
involved in heart development IDA
IDA: 通过直接分析推断
21280046 RGD
involved in isoquinoline alkaloid metabolic process IEP
IEP: 通过表达模式推断
18305432 RGD
involved in phthalate metabolic process IEP
IEP: 通过表达模式推断
21145954 RGD
involved in phytoalexin metabolic process IEP
IEP: 通过表达模式推断
19185027 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
21276429 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
21078367 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
19494803 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
21296669 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
11914591 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
16713504 RGD
involved in response to ether IEP
IEP: 通过表达模式推断
15896472 RGD
involved in response to growth factor IEP
IEP: 通过表达模式推断
21236244 RGD
involved in response to herbicide IEP
IEP: 通过表达模式推断
20553223 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
12692140 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
21075155 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
11858766 RGD
involved in response to insecticide IEP
IEP: 通过表达模式推断
21277943 RGD
involved in response to isolation stress IEP
IEP: 通过表达模式推断
19893991 RGD
involved in response to light stimulus IEP
IEP: 通过表达模式推断
21185915 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
21239462 RGD
involved in response to metal ion IEP
IEP: 通过表达模式推断
20224926 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
17437548 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
21364997 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
20951685 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
21129429 RGD
involved in response to pyrethroid IEP
IEP: 通过表达模式推断
16229977 RGD
involved in response to salt stress IEP
IEP: 通过表达模式推断
21113619 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
11883789 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
21396352 RGD
involved in response to zinc ion IEP
IEP: 通过表达模式推断
20553223 RGD
involved in social behavior IEP
IEP: 通过表达模式推断
15345906 RGD
involved in sphingolipid metabolic process IEP
IEP: 通过表达模式推断
21076868 RGD
involved in terpene metabolic process IEP
IEP: 通过表达模式推断
20934257 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
14681933 RGD
located in cytoplasmic vesicle membrane IDA
IDA: 通过直接分析推断
11943812 RGD
located in dendrite IDA
IDA: 通过直接分析推断
21362438 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
11943812 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
21325515 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
20434498 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
15496595 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
14681933 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine 3-monooxygenase

tyrosine 3-hydroxylase

相关产品

Approval
生物活性分子 (10)
目录号 产品名 作用方式
纯度 是否罕见病
HY-100754 Ritlecitinib Inhibitor 99.80% 是
HY-N0394 L-Cystine 99.84% 否
HY-107916 Thyrotropin Inhibitor / 否
HY-B0976 Fenoterol Agonist 99.08% 否
HY-B0976A Fenoterol hydrobromide Agonist 99.90% 否
HY-109520 Glatiramer acetate ≥98.0% 否
HY-17002 Suplatast (Tosilate) Inhibitor 99.67% 否
HY-100754C Ritlecitinib tosylate Inhibitor 99.77% 是
HY-100754A Ritlecitinib (malonate) Inhibitor / 否
HY-B0976AR Fenoterol hydrobromide (Standard) Agonist / 否
抗体抑制剂 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99025 Lebrikizumab Inhibitor 99.90% 否
HY-P99396 Spesolimab Inhibitor 99.10% 否
HY-P99256 Tildrakizumab Antagonist 99.46% 否
Clinical Phase
生物活性分子 (16)
目录号 产品名 作用方式
纯度 Phase
HY-101092 QS-21 Activator 99.67% Phase 3
HY-B2132 Tryptamine 99.77% Phase 3
HY-10535 Evofosfamide Inducer ≥98.0% Phase 3
HY-112137 Trehalose-6,6'-dibehenate 99.92% Phase 3
HY-148074 Zelnecirnon Inhibitor 99.84% Phase 2
HY-16734A Amiselimod hydrochloride Agonist 98.71% Phase 2
HY-15342 Timapiprant Antagonist 99.48% Phase 2
HY-118250 GSK2245035 99.85% Phase 2
HY-17632 Tarloxotinib bromide Inhibitor 99.26% Phase 2
HY-15342A Timapiprant sodium Inhibitor 99.61% Phase 2
HY-114141 BI-671800 Antagonist 99.36% Phase 2
HY-103637A Vimirogant hydrochloride Inhibitor 98.39% Phase 2
HY-16734 Amiselimod Modulator / Phase 2
HY-12284 NVP-QAV680 Antagonist / Phase 2
HY-103637 Vimirogant Inhibitor / Phase 2
HY-137131 DC-Chol hydrochloride 99.91% Phase 1
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P990090 Rademikibart Inhibitor 98.69% Phase 3
HY-P991258 CNTO-5825 / Phase 1
Pre-clinical Phase
生物活性分子 (176)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153808 Complete Freund's adjuvant (CFA) / 否
HY-15826 SGC-CBP30 Inhibitor 99.83% 否
HY-126360 Oxazolone ≥98.0% 否
HY-P1240 Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 99.97% 否
HY-125801 3-Oxo-5β-cholanoic acid Inhibitor 99.37% 否
HY-116961 TH1020 99.81% 否
HY-P1240A Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA 99.96% 否
HY-P10408 Candidalysin Activator 99.38% 否
HY-125276 TH5487 Inhibitor 98.76% 否
HY-12776 GSK805 Inhibitor 98.01% 否
HY-147313 TH10785 Activator 99.93% 否
HY-134771 YM-341619 Inhibitor 98.01% 否
HY-106224B Orexin A (human, rat, mouse) acetate Agonist 99.93% 否
HY-150298 Soquelitinib Inhibitor 99.71% 否
HY-114360 Taurohyodeoxycholic acid Inhibitor 99.73% 否
HY-N2279 Kurarinone Activator 99.47% 否
HY-123604 TH1834 99.44% 否
HY-111818 TH34 Inhibitor 99.52% 否
HY-W009203 L-Cystine dihydrochloride ≥98.0% 否
HY-138113 Pyrrothiogatain Inhibitor 98.61% 否
HY-155950 TH9619 99.33% 否
HY-12814 TH588 Inhibitor 99.20% 否
HY-101392 Harmane Inhibitor 99.91% 否
HY-P3993A (Gly14)-Humanin (human) acetate Inhibitor 99.86% 否
HY-122818 BpV(phen) trihydrate ≥98.0% 否
HY-N0440 Germacrone 99.76% 否
HY-123604A TH1834 dihydrochloride 99.68% 否
HY-153808B Complete Freund's adjuvant (CFA, 1 mg/ml) / 否
HY-N0592A Demethyleneberberine chloride 98.90% 否
HY-108522 PA452 Antagonist ≥99.0% 否
HY-124573 (R)-Odafosfamide 98.52% 否
HY-147410 Ulefnersen 94.55% 否
HY-122630 TH-257 Inhibitor 98.36% 否
HY-W011220 Ciglitazone Agonist 98.89% 否
HY-16965 TH287 Inhibitor 98.29% 否
HY-B0927 Hydrastine Inhibitor 99.57% 否
HY-P1907 Human Papillomavirus (HPV) E7 protein (49-57) 98.30% 否
HY-136065 bpV(phen) ≥98.0% 否
HY-N4084 Thonningianin A Inducer 99.73% 否
HY-125209 TH5427 Inhibitor 99.92% 否
HY-150168 TH-Z145 Inhibitor 97.05% 否
HY-135909 TH1217 Modulator 99.73% 否
HY-N6636 Valencene Inhibitor 81.81% 否
HY-W012732 Isoquinoline Inhibitor 99.58% 否
HY-W677684 Nurr1 agonist 2 Agonist 98.03% 否
HY-145848 ERRγ agonist-1 Agonist 98.70% 否
HY-161296 TH6342 Inhibitor 99.15% 否
HY-147410A Ulefnersen sodium 94.55% 否
HY-150167 TH-Z93 Inhibitor 98.41% 否
HY-125390 SM-360320 Agonist 99.41% 否
HY-139780 JNJ-61803534 Inhibitor 99.84% 否
HY-142998 Vaxfectin 98.12% 否
HY-144200 CCR8 antagonist 2 Antagonist 98.34% 否
HY-W009356 L-Cystine hydrochloride ≥98.0% 否
HY-120000 MS402 Inhibitor 98.36% 否
HY-151539 TH470 Inhibitor 99.57% 否
HY-W010520 Methylisothiazolinone 99.37% 否
HY-W002291 p-Fluoro-L-phenylalanine 99.91% 否
HY-156466 QL-1200186 Inhibitor 99.95% 否
HY-123468 HA-1004 Inhibitor 99.04% 否
HY-N3138 Ombuoside 99.68% 否
HY-P10532 Myelin basic protein, MBP (68-86) 99.28% 否
HY-P1252 Parathyroid Hormone (1-34), bovine Agonist 99.88% 否
HY-146243 TH-Z835 99.58% 否
HY-172208 PROTAC cGAS degrader-1 Degrader 99.07% 否
HY-N10534 Lewis X trisaccharide Inhibitor 99.91% 否
HY-N7501 Isoformononetin Inhibitor 99.60% 否
HY-120574 TH1338 Inhibitor 98.77% 否
HY-120785 SR1555 Antagonist 99.69% 否
HY-145809 FASN-IN-5 Inhibitor 99.98% 否
HY-159102 PVP-037.2 Agonist 99.18% 否
HY-16668 Tyrphostin A1 Inhibitor 98.96% 否
HY-126037 (±)-ML 209 Antagonist 99.87% 否
HY-W018829 10-Undecenal 97.96% 否
HY-113238F FITC-Lithocholic acid 3-sulfate 90.01% 否
HY-B0976AS Fenoterol-d6 hydrobromide Agonist 98.02% 否
HY-138115 7ß,27-Dihydroxycholesterol Activator ≥99.0% 否
HY-142938 RORγt agonist 3 Agonist 98.12% 否
HY-153663 TH-Z827 Inhibitor / 否
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% 否
HY-N0592 Demethyleneberberine ≥98.0% 否
HY-P1052A Myelin Basic Protein(87-99) TFA 99.23% 否
HY-P2299A Protein E7(43-62) TFA 98.85% 否
HY-P5333A Aβ1-14-εK-KKK-MvF5 Th acetate Inhibitor 99.93% 否
HY-W010243 Methylisothiazolinone hydrochloride 99.40% 否
HY-167692 JI069 Inhibitor 98.03% 否
HY-P5333 Aβ1-14-εK-KKK-MvF5 Th 98.05% 否
HY-128353 ROR agonist-1 Antagonist / 否
HY-125209A TH5427 hydrochloride Inhibitor / 否
HY-126252 A-9758 Inhibitor / 否
HY-130243 RORγt Inverse agonist 6 Antagonist 98.97% 否
HY-142806 RORγt inverse agonist 26 / 否
HY-159507 Brezivaptan Antagonist / 否
HY-160040A Cobitolimod sodium Agonist / 否
HY-110295 SPL-334 Inhibitor / 否
HY-112348 HA-1004 hydrochloride Inhibitor / 否
HY-116890 CRTh2 antagonist 4 Antagonist / 否
HY-118250A GSK2245035 maleate / 否
HY-118428 Fluenetil / 否
HY-120225 NJK14047 Inhibitor / 否
HY-120785A SR1555 hydrochloride Antagonist / 否
HY-123568 PBI-1393 Inhibitor / 否
HY-125693 L685818 Inhibitor / 否
HY-132828 Odatroltide Inhibitor / 否
HY-132851 Corixetan / 否
HY-135773 CRTh2 antagonist 3 / 否
HY-135843 TH-263 Control ≥99.0% 否
HY-137292 PTB7-Th / 否
HY-139193 TH1760 Inhibitor / 否
HY-142703 RORγt inverse agonist 28 Inhibitor / 否
HY-142937 RORγt agonist 2 Agonist / 否
HY-143885 JAK1/TYK2-IN-3 Inhibitor / 否
HY-145491 Resolvin D5 / 否
HY-145577 Lafadofensine Inhibitor / 否
HY-149029 TH-6 95.00% 否
HY-149040 Odafosfamide Inhibitor / 否
HY-153662 TH-Z816 Inhibitor / 否
HY-155219 TH9028 Inhibitor / 否
HY-155487 JTE-151 Inhibitor 99.34% 否
HY-155505 AHR agonist 4 Agonist / 否
HY-155680 BET BD2-IN-1 Inhibitor / 否
HY-157020 UniPR1449 Antagonist / 否
HY-158694 TLR7 agonist 20 Agonist / 否
HY-160040 Cobitolimod Agonist / 否
HY-161255 3,4-DAA Inhibitor / 否
HY-162490 TF-S14 Inhibitor / 否
HY-162727 GCS-12 / 否
HY-163704 KRN7000 analog 1 / 否
HY-163801 Nurr1 agonist 9 Agonist / 否
HY-168207 TH023 Inhibitor / 否
HY-168347 TH152 Ligand / 否
HY-172692 DSPE-PEG1000-TH / 否
HY-172693 DSPE-PEG2000-TH / 否
HY-172694 DSPE-PEG5000-TH / 否
HY-173025 Nurr1 agonist 12 Agonist / 否
HY-174903 ITK-IN-6 Inhibitor / 否
HY-175365 GCS-12–6 Ligand / 否
HY-176262 TH10184 Ligand / 否
HY-176263 TH10184-octanedioic acid / 否
HY-176273 RORγt inverse agonist 35 Agonist / 否
HY-176535 KB-0118 Inhibitor / 否
HY-177277 HM5023507 Inhibitor / 否
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / 否
HY-N6636R Valencene (Standard) Inhibitor / 否
HY-N7501S Isoformononetin-d3 98.64% 否
HY-N7512 Asimilobine / 否
HY-P10982 SjDX5-53 Inducer / 否
HY-P10984 FNIII14 Inhibitor / 否
HY-P1252A Parathyroid Hormone (1-34), bovine TFA Agonist / 否
HY-P2299 Protein E7(43-62) / 否
HY-P3993 (Gly14)-Humanin (human) Inhibitor / 否
HY-P4389 (Asp28)-Glucagon (1-29) (human, rat, porcine) Activator / 否
HY-P4790 Acetyl-Exenatide Inhibitor / 否
HY-RS14467 TH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W010243S Methylisothiazolinone-d3 hydrochloride / 否
HY-W010520R Methylisothiazolinone (Standard) / 否
HY-W700834 Harman-d3 / 否
HY-W777360 Harman-13C2,15N Inhibitor / 否
HY-101392A Harmane hydrochloride Inhibitor / 否
HY-11054 TH-237A 98.55% 否
HY-112863 RORγt inhibitor 3 Inhibitor / 否
HY-122349 Lotrifen / 否
HY-12814A TH588 hydrochloride Inhibitor / 否
HY-138143 N-(p-Tosyl)-GPR-pNA acetate / 否
HY-157675 1,2-Dinervonoyl-sn-glycero-3-phosphocholine / 否
HY-164454 AJI-100 Inhibitor / 否
HY-164455 AJI-214 Inhibitor / 否
HY-16965A TH287 hydrochloride Inhibitor / 否
HY-175301 TH16 / 否
HY-177300 TLR7/8 agonist 13 / 否
HY-N3548 Catalpalactone Inhibitor / 否
HY-P10463 ssK36 Inhibitor / 否
HY-RS16660 Th Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23095 Th Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W130878 4-Octylphenol Activator / 否
HY-101871 Trehalose 6-behenate / 否
抗体抑制剂 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990121 Anti-Mouse IL-4 Antibody (11B11) Inhibitor 95.00% 否
HY-P990219 Anti-Mouse IL-2 Antibody (JES6-1A12) Inhibitor 95.00% 否
HY-P990208 Anti-Mouse IL-9 Antibody (9C1) Inhibitor 95.00% 否
HY-P990124 Anti-Mouse GITR Antibody (DTA-1) 98.47% 否
HY-P990145 Anti-Mouse VISTA Antibody (13F3) Inhibitor ≥95.0% 否
HY-P990177 Anti-Mouse Notch4 Antibody (HMN4-14) Inhibitor / 否
HY-P990206 Anti-Mouse Jagged 2 Antibody (HMJ2-1) Inhibitor / 否
HY-P990796 Anti-Mouse IL-2 Antibody (S4B6-1) Inhibitor / 否
HY-P991274 BMS-986010 Inhibitor / 否
HY-P991380 TXB4 Inhibitor / 否
HY-P991467 RG-7258 Inhibitor / 否
HY-P990252 Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Th NCBI NCBI:7054
Canis familiaris Th NCBI NCBI:403444
Felis catus Th NCBI NCBI:101090720
Macaca fascicularis Th NCBI NCBI:102134074
Canis lupus familiaris Th NCBI
Mus musculus Th NCBI NCBI:21823
Susscrofa domestica Th NCBI
Leporidae Th NCBI
Macaca mulatta Th NCBI NCBI:721137
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