1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. E3330

E3330 (Synonyms: APX-3330)

目录号: HY-19357
产品使用指南

E3330 (APX-3330) 是一种直接,口服有效的 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂,可抑制 NF-κB DNA 结合活性。E3330 (APX-3330) 阻断 TNF-α 诱导的肝癌细胞系中 IL-8 产生的激活。E3330 (APX-3330) 显示出多功能水平的抗癌特性,例如抑制癌细胞的生长和迁移。

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E3330 Chemical Structure

E3330 Chemical Structure

CAS No. : 136164-66-4

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Description

E3330 (APX-3330) is a direct, orally active AP endonuclease 1 (APE1; also known as REF-1) inhibitor, which suppresses NF-κB DNA-binding activity. E3330 (APX-3330) blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines. E3330 (APX-3330) shows anticancer properties, such as inhibition of cancer cell growth and migration[1-4].

IC50 & Target

DNA Synthesis, APE1[1-4]

Molecular Weight

378.46

Formula

C₂₁H₃₀O₆

CAS No.

136164-66-4

SMILES

CCCCCCCCC/C(C(O)=O)=C\C1=C(C)C(C(OC)=C(OC)C1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
E3330
目录号:
HY-19357
需求量:

E3330

Cat. No.: HY-19357