1. Epigenetics
    PI3K/Akt/mTOR
    Cell Cycle/DNA Damage
  2. AMPK
    HDAC
  3. Marein

Marein 

目录号: HY-N7676 纯度: 98.65%
产品使用指南

Marein 通过减少对线粒体功能的损害和 AMPK 信号通路的激活而具有神经保护作用。Marein 通过 CaMKK/AMPK/GLUT1 促进葡萄糖摄取,通过 IRS/Akt/GSK-3β 增加糖原合成,并通过 Akt/FoxO1 减少糖异生,从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。Marein 是一种 HDAC 抑制剂,IC50 为 100 µM。Marein 具有有益的抗氧化,降压,降血脂和抗糖尿病作用。

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Marein Chemical Structure

Marein Chemical Structure

CAS No. : 535-96-6

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Description

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].

IC50 & Target

IC50: 100 µM (HDAC)[3]

Molecular Weight

450.39

Formula

C₂₁H₂₂O₁₁

CAS No.

535-96-6

中文名称

马里甙

SMILES

O=C(C1=CC=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C(O)=C1O)/C=C/C3=CC=C(O)C(O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
  • 摩尔计算器

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Keywords:

MareinAMPKHDACAMP-activated protein kinaseHistone deacetylasesCaMKKGLUT1IRSAktGSK-3βFoxO1antioxidativeantihypertensiveantihyperlipidemicantidiabeticneuroprotectiveglycosideInhibitorinhibitorinhibit

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产品名称:
Marein
目录号:
HY-N7676
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