Gomisin N  (Synonyms: 戈米辛N)

Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease^{[1][2][3][4][5][6][7][8][9][10]}.

Gomisin N (100 μM，30 min) 可增强 TRAIL 诱导的 Hela 细胞凋亡^[1]。
Gomisin N (10-100 μM；30 min-6 h) 可激活 C2C12 肌管中 AMPK 和 Akt 信号传导，并刺激葡萄糖摄取^[2]。
Gomisin N (2.5-20 μM；1 h) 在 LPS 刺激的 Raw 264.7 细胞中表现出抗炎作用，可减少一氧化氮 (NO) 的产生和促炎细胞因子 (IL-1β、IL-6、TNF-α) 的表达^[3]。
Gomisin N (25-100 μM；48 h) 可降低 HepG2 和 HCCLM3 细胞的活力^[5]。
Gomisin N (40-320 μM; 24 h) 显著诱导 HepG2 细胞的抗增殖和促凋亡作用^[6]。
Gomisin N (10-100 μM; 16 h) 显示出对 HepG2 细胞中内质网应激诱导的肝脂肪变性的保护作用^[8]。
Gomisin N (1-10 μM; 72 h) 通过激活 Melan-A 细胞中的 PI3K/Akt 和 MAPK/ERK 信号通路来抑制黑素生成^[9]。
Gomisin N (50 μM；24 h) 通过抑制 GSK3β，激活 Nrf2 信号通路在 H₂O₂ 处理的 SH-SY5Y/APP695swe 细胞中发挥抗氧化作用^[10]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gomisin N (20 mg/kg；口服；每日一次；疗程 6 周) 可降低高脂饮食 (HFD) 诱导的肥胖 C57BL/6 小鼠的高血糖症并改善葡萄糖耐量^[2]。
Gomisin N (2-10 mg/kg；口服；每周 3 次；疗程 8 周) 可预防 HFD 诱导的肥胖并改善 C57BL/6 小鼠的肝脏脂肪变性^[4]。
Gomisin N (1-30 mg/kg；口服；4 天) 可缓解 Tunicamycin (HY-A0098) 诱导的肝脏内质网应激和甘油三酯蓄积，并改善 C57BL/6 小鼠的肝损伤^[8]。
Gomisin N (10-20 mg/kg；灌胃；2 个月) 可以改善 Aβ_25-35 诱导的 AD 大鼠的学习记忆能力，减少海马和皮质区 Aβ 斑块面积，增加神经元数量,改善氧化应激状态^[10]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

400.46

C₂₃H₂₈O₆

69176-52-9

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Inoue H, et al. Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5. Int J Oncol. 2012 Apr;40(4):1058-65.  [Content Brief]

  [2]. Jung DY, et al. Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):587-593.  [Content Brief]

  [3]. Oh SY, et al. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem. 2010;74(2):285-91.  [Content Brief]

  [4]. Jang MK, et al. Gomisin N inhibits adipogenesis and prevents high-fat diet-induced obesity. Sci Rep. 2017 Jan 9;7:40345.  [Content Brief]

  [5]. Zhu PL, et al. Gomisin N Exerts Anti-liver Cancer Effects and Regulates PI3K-Akt and mTOR-ULK1 Pathways in Vitro. Biol Pharm Bull. 2020;43(8):1267-1271.  [Content Brief]

  [6]. Yim SY, et al. Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma. Mol Med Rep. 2009 Sep-Oct;2(5):725-32.  [Content Brief]

  [7]. Takimoto Y, et al. Gomisin N in the herbal drug gomishi (Schisandra chinensis) suppresses inducible nitric oxide synthase gene via C/EBPβ and NF-κB in rat hepatocytes. Nitric Oxide. 2013 Jan 15;28:47-56.  [Content Brief]

  [8]. Jang MK, et al. Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis. Biol Pharm Bull. 2016 May 1;39(5):832-8.  [Content Brief]

  [9]. Chae JK, et al. Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes. Int J Mol Sci. 2017 Feb 22;18(2):471.  [Content Brief]

  [10]. Song M, et al. Gomisin N rescues cognitive impairment of Alzheimer's disease by targeting GSK3β and activating Nrf2 signaling pathway. Phytomedicine. 2024 Sep;132:155811.  [Content Brief]