Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.
“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates.
Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).
The Chinese National Compound Library (CNCL) composes 1.4 million compounds possessing diversified structures. Coupled with this library will be advanced sample handling, information management and quality control systems. Most compounds in the library are drug-like, conforming to “Lipinski’s Rule of Five”, such as MW < 500, logP < 5, Hydrogen Bond Donors < 5.
Diversity-based screening continues to be a vital tool for drug discovery. Efficiency and productivity can be improved by using screening libraries that offer maximum diversity whilst retaining drug-like properties. Chemspace Scaffold derived set composes 10,119 compounds, which including 3,373 scaffolds, 3 compounds per each. This library has exceptional coverage of drug-like chemical space.
A specially synthesized set of 2,470 compounds able to mimic glycosides and their interaction with proteins. The main emphasis of library design was made on drug-like compounds enriched with H-bond donors (possess at least two H-bond donors) and bearing nature-like Fsp3–rich scaffolds with diverse spatial orientation of H-bond donors and different 3D-shapes.
A unique collection of 56,320 novel small molecules with high CNS MPO (Central Nervous System Multiparameter Optimization) scores. The CNS-active molecules which are able to penetrate blood-brain barrier (BBB) were low polar surface area, low degree of possible hydrogen bond formation and low ClogP values.
CHFR; E3 ubiquitin-protein ligase CHFR; Checkpoint with forkhead and ring finger domains protein; ring finger protein 196; ring-type E3 ubiquitin transferase CHFR
E3 ubiquitin-protein ligase MARCHF2; Membrane-associated ring finger protein 2; Membrane-associated ring-CH protein II; MARCH-II; ring finger protein 172; ring-type E3 ubiquitin transferase MARCHF2
CHFR; E3 ubiquitin-protein ligase CHFR; Checkpoint with forkhead and ring finger domains protein; ring finger protein 196; ring-type E3 ubiquitin transferase CHFR
RNF4; E3 ubiquitin-protein ligase RNF4; ring finger protein 4; ring-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF
RNF4; E3 ubiquitin-protein ligase RNF4; ring finger protein 4; ring-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF
UHRF2; E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like ring finger protein; Np95-like ring finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; ring finger protein 107; ring-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and ring finger domain-containing protein 2; Ubiquitin-like-containing PHD and ring finger domains protein 2
TRIM54; Tripartite motif-containing protein 54; Muscle-specific ring finger protein; MuRF; Muscle-specific ring finger protein 3; MuRF-3; MuRF3; ring finger protein 30
TRIM54; Tripartite motif-containing protein 54; Muscle-specific ring finger protein; MuRF; Muscle-specific ring finger protein 3; MuRF-3; MuRF3; ring finger protein 30
RNF135; E3 ubiquitin-protein ligase RNF135; RIG-I E3 ubiquitin ligase; REUL; ring finger protein 135; ring finger protein leading to RIG-I activation; Riplet; ring-type E3 ubiquitin transferase RNF135
RNF135; E3 ubiquitin-protein ligase RNF135; RIG-I E3 ubiquitin ligase; REUL; ring finger protein 135; ring finger protein leading to RIG-I activation; Riplet; ring-type E3 ubiquitin transferase RNF135
TRIM69蛋白是一种E3泛素连接酶,通过泛素化登革热病毒NS3等病毒蛋白,从而限制病毒感染(如登革热病毒、印第安纳水泡性口炎病毒),从而限制感染。TRIM69 Protein, Human 是重组的 TRIM69 蛋白,由 E. coli 表达,不带标签。TRIM69 Protein, Human 全长 499 个氨基酸。
RNF141 蛋白作为精子发生中的潜在参与者而出现,表明其在男性生殖细胞发育中发挥作用。这一含义凸显了它在控制生殖生物学的复杂调控网络中的重要性。RNF141 Protein, Human 是重组的 RNF141 蛋白,由 E. coli 表达,不带标签。RNF141 Protein, Human 全长 229 个氨基酸。
RING finger (RNF) 蛋白含有 RING 结构域,并发挥 E3 泛素连接酶的作用,介导泛素与靶蛋白的共价附着。RNF 蛋白在癌症和病毒感染中发挥作用。RNF113B 属于 RNF 蛋白家族。RNF113B Protein, Human 是重组的 RNF113B 蛋白,由 E. coli 表达,不带标签。RNF113B Protein, Human 全长 321 个氨基酸。
ring finger protein 88; RNF88; TRIM5; TRIM5_HUMAN; TRIM5alpha; Tripartite motif containing 5; tripartite motif protein TRIM5; Tripartite motif-containing protein 5
MTrim63; uRF 1; MuRF-1; Muscle-specific ring finger protein 1; Muscle-specific ring finger protein 1; E3 ubiquitin-protein ligase TRIM63; FLJ32380; IRF; MURF1; MURF 1; MURF2; RNF28; SMRZ; Iris ring finger protein; Muscle specific ring finger protein 2; ring finger protein 28; RNF28; SMRZ; Striated muscle ring zinc finger protein; TRIM 63; TRIM63; Tripartite motif containing 63; Tripartite motif containing protein 63; Ubiquitin ligase TRIM63.
ELISA; IHC-P; IHC-F; Flow-Cyt; IF
Human, Mouse(predicted: Rat, Pig, Cow, Horse, Rabbit)
MuRF1 Antibody is an unconjugated, approximately 39 kDa, rabbit-derived, anti-MuRF1 polyclonal antibody. MuRF1 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, and predicted: rat, pig, cow, horse, rabbit background without labeling.
BRCA1; RNF53; Breast cancer type 1 susceptibility protein; ring finger protein 53
WB, IHC-F, IHC-P, ICC/IF, ELISA
Human, Rat
BRCA1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 208 kDa, targeting to BRCA1. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Rat.
RCHY1; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; ring finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; ring finger
TRAF4; CART1; MLN62; RNF83; TNF receptor-associated factor 4; Cysteine-rich domain associated with ring and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; ring finger protein 83
TRAF6; RNF85; TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; ring finger protein 85
WB
Human, Rat
TRAF6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to TRAF6. It can be used for WB assays with tag free, in the background of Human, Rat.
TRIM28; KAP1; RNF96; TIF1B; Transcription intermediary factor 1-beta; TIF1-beta; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; ring finger protein 96; Tripart
WB, IHC-F, IHC-P, ICC/IF
Human
KAP1 Antibody (YA719) is a non-conjugated and Mouse origined monoclonal antibody about 89 kDa, targeting to KAP1 (4E1). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.
Proteasome beta 8 Antibody (YA684) is a non-conjugated and Mouse origined monoclonal antibody about 30 kDa, targeting to Proteasome beta 8 (3G3). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Rat.