2. Immunology/Inflammation Apoptosis MAPK/ERK Pathway Stem Cell/Wnt Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor PI3K/Akt/mTOR Epigenetics NF-κB JAK/STAT Signaling
  3. COX Apoptosis MEK ERK PPAR AMPK NF-κB Interleukin Related TNF Receptor STAT Wnt
  4. Flurbiprofen axetil

Flurbiprofen axetil  (Synonyms: 氟比洛芬酯)

目录号: HY-101481 纯度: 99.34%
COA 产品使用指南 技术支持

Flurbiprofen axetil 是一种非选择性 COX 抑制剂和非甾体抗炎剂，具有抗炎和镇痛作用。Flurbiprofen axetil 通过抑制 MEK/ERK 信号通路抑制基底样乳腺癌转移。Flurbiprofen axetil 可以通过或部分激活 PPAR-γ 在大鼠局灶性脑缺血后促进神经保护作用。Flurbiprofen axetil 通过减少短暂性整体脑缺血/再灌注大鼠模型中的炎症来减轻脑缺血/再灌注损伤。Flurbiprofen axetil 可通过 AMPKα/NF-κB 信号通路减轻轻度认知障碍 (MCI) SD 大鼠模型中的炎症反应和认知功能。

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Flurbiprofen axetil

Flurbiprofen axetil Chemical Structure

CAS No. : 91503-79-6

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规格 价格 是否有货 数量
5 mg ￥260
In-stock
10 mg ￥420
In-stock
25 mg ￥715
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50 mg ￥1100
In-stock
100 mg ￥1800
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Customer Review

Other Forms of Flurbiprofen axetil:

Flurbiprofen axetil 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

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ERK ERK1 ERK2 ERK5 ERK8

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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STAT3 STAT5 STAT6 STAT1

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Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flurbiprofen axetil is a non-selective COX inhibitor and a nonsteroidal anti-inflammatory agent with anti-inflammatory and analgesic effects. Flurbiprofen axetil inhibits basal-like breast cancer metastasis by inhibiting the MEK/ERK signaling pathway. Flurbiprofen axetil can promote neuroprotection after focal cerebral ischemia in rats by partially activating PPAR-γ. Flurbiprofen axetil alleviates cerebral ischemia/reperfusion injury by reducing inflammation in a transient global cerebral ischemia/reperfusion rat model. Flurbiprofen axetil can alleviate inflammatory responses and cognitive function in a mild cognitive impairment (MCI) SD rat model through the AMPKα/NF-κB signaling pathway[1][2][3][4][5].

IC50 & Target[1]

COX

 

体外研究
(In Vitro)

Flurbiprofen axetil (0-160 nM，1-6 天) 在 BT-549 和 MDA-MB-231 细胞中不影响增殖和活性，但抑制的迁移和侵袭[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flurbiprofen axetil 相关抗体:

Cell Migration Assay [2]

Cell Line: BT-549 and MDA-MB-231 cells
Concentration: 0 nM, 40 nM, 80 nM, 160 nM
Incubation Time: 24 h
Result: Inhibited the migration and invasion, and 80 nM was the most appropriate concentration to use.
体内研究
(In Vivo)

Flurbiprofen axetil (0.1 g/100 mL，滴眼，每日 2 次，24 小时) 在内毒素诱发的葡萄膜炎 (EIU) 兔模型中具有抗炎作用[1]。
Flurbiprofen axetil (10 mg/kg，腹腔注射，每两天一次，28 天) 通过抑制裸鼠模型中的 MEK/ERK 信号通路抑制乳腺癌转移[2]。
Flurbiprofen axetil (10 mg/kg，静脉注射，一次) 可通过激活 PPAR-γ (或部分激活 PPAR-γ) 在大鼠局灶性脑缺血后发挥神经保护作用[3]。
Flurbiprofen axetil (5-10 mg/kg，静脉注射，一次) 通过减轻全脑缺血雄性 SD 大鼠的炎症和脑水肿，保护大脑免受脑缺血再灌注损伤[4]。
Flurbiprofen axetil (10 mg/kg，静脉注射，一次) 可通过 AMPKα/NF-κB 信号通路减轻福尔马林诱发的 MCI SD 大鼠模型中的炎症反应和认知功能[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: EIU rabbit model [1]
Dosage: 0.1 g/100 mL
Administration: drops into the eyes, 2 times/day, 24 h
Result: Reduce inflammatory response and leukocyte counts and PGE2 levels, reduce iris and retinal disorder and inflammatory cell infiltration.
Animal Model: Breast cancer metastasis (1 × 106 MDA-MB-231-luc cells/100 µL, i.v.) nude mice (Female Balb/c, 6 weeks) model[2]
Dosage: 10  mg/kg
Administration: i.p., once every two days, 28 days
Result: Inhibited the expression of CD44 and VCAM-1, inhibited the metastasis. Inhibited the expression levels of key EMT markers (particularly N-cadherin and vimentin) without affecting proteins involved in the PI3K/AKT signaling pathway, Wnt/β-catenin signaling pathway, Janus kinase/STAT3 signaling pathway, and transforming growth factor-β/Smad signaling pathway. Inhibited the phosphorylation of MEK/ERK signaling pathway proteins and ERK phosphorylation.
Animal Model: tMCAO male SD rat (8-12 weeks old, 280-320 g)[3]
Dosage: 10 mg/kg
Administration: i.v., once
Result: Reduced neurological deficit score, reduced infarct volume percentage.
Animal Model: Global cerebral ischemia male SD rat (300-350 g) model[3]
Dosage: 5 mg/kg, 10 mg/kg
Administration: i.v., once
Result: Reduced neurological deficit score. Reduced cerebral I/R-induced neuronal damage, reduced cell apoptosis, TUNEL positive cells, cleaved caspase-3 protein expression. Reduces AQP4 and AQP9 mRNA expressions, reduces TXB2 and TXB2/6-keto-PGF1α in discrete cortex. Decreases cerebral I/R-induced inflammation in hippocampus, reduced serum TNF-α, IL-1β and ICAM-1 and NF-κB mRNA expressions.
Animal Model: Formalin-induced MCI SD rat (male, 250-300 g, 16-17 weeks old) model[3]
Dosage: 10 mg/kg
Administration: i.v., once
Result: Relieved inflammatory pain induced by formalin injection, alleviated the effect on the cognitive function, reduced the effect on neuronal damage, decreased levels of TNF-α and IL-6 in the hippocampus. Inhibited NF-κB p65 by activating AMPKα.
分子量

330.35

Formula

C19H19FO4
CAS 号
性状

油状物

颜色

Colorless to off-white

中文名称

氟比洛芬酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (756.77 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0271 mL 15.1355 mL 30.2709 mL
5 mM 0.6054 mL 3.0271 mL 6.0542 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Flurbiprofen axetil 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0271 mL 15.1355 mL 30.2709 mL 75.6773 mL
5 mM 0.6054 mL 3.0271 mL 6.0542 mL 15.1355 mL
10 mM 0.3027 mL 1.5135 mL 3.0271 mL 7.5677 mL
15 mM 0.2018 mL 1.0090 mL 2.0181 mL 5.0452 mL
20 mM 0.1514 mL 0.7568 mL 1.5135 mL 3.7839 mL
25 mM 0.1211 mL 0.6054 mL 1.2108 mL 3.0271 mL
30 mM 0.1009 mL 0.5045 mL 1.0090 mL 2.5226 mL
40 mM 0.0757 mL 0.3784 mL 0.7568 mL 1.8919 mL
50 mM 0.0605 mL 0.3027 mL 0.6054 mL 1.5135 mL
60 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.2613 mL
80 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9460 mL
100 mM 0.0303 mL 0.1514 mL 0.3027 mL 0.7568 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flurbiprofen axetil91503-79-6氟比洛芬酯COXApoptosisMEKERKPPARAMPKNF-κBInterleukin RelatedTNF ReceptorSTATWntCyclooxygenaseMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesPeroxisome proliferator-activated receptorsAMP-activated protein kinaseNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRInhibitorMEK/ERKAMPKα/NF-κBMCI SD rat modelBT-549 cellsMDA-MB-231 cellstMCAOEIU rabbit modelinhibitorinhibit

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