Il6 - interleukin 6 Gene

中文名称：白细胞介素 6

种属: Mus musculus

同用名: Il-6

关于 Il6

功能概要

该基因编码白介素细胞因子家族的一个成员，该家族在免疫反应、造血、炎症和急性期反应中具有重要功能。小鼠体内编码蛋白的异位过度表达导致循环中浆细胞过多，从而导致死亡。缺乏编码蛋白的小鼠在肝脏急性期反应、一些免疫机制、响应雌激素的骨吸收、肝再生和伤口愈合方面表现出异常。可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2015 年 9 月]

This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]