TNF - tumor necrosis factor Gene

中文名称：肿瘤坏死因子

种属: Rattus norvegicus

同用名: Tnfa; RATTNF; TNF-alpha

关于 TNF

功能概要

该基因编码的蛋白可启动肿瘤坏死因子受体结合活性。参与多个过程，包括细胞通讯的正向调节；大分子代谢过程的正向调控；和神经元死亡的正调节。位于多个细胞成分中，包括质膜的外侧；细胞外空间；和神经细胞体。用于研究多种疾病，包括脑血管疾病（多发性）；肝病（多发性）；消化性食管炎;围产期坏死性小肠结肠炎；和脑室周围白质软化。多种疾病的生物标志物，包括脑部疾病（多种）；充血性心力衰竭（多发性）；炎症性肠病（多发性）；肺部疾病（多发）；和非酒精性脂肪性肝病（多种）。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；自身免疫性疾病（多种）；眼病（多发）；肺部疾病（多发）；和皮肤病（多种）。与人类 TNF（肿瘤坏死因子）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor). [provided by Alliance of Genome Resources, Apr 2022]