1. Gene
  2. Tyr - tyrosinase Gene

Tyr - tyrosinase Gene

种属: Mus musculus

同用名: c; Oca1; skc35; albino

基因 ID: 22173 | 基因类型: protein coding

关于 Tyr

功能概要

Enables protein homodimerization activity. Acts upstream of or within several processes, including melanin biosynthetic process; pigmentation; and thymus development. Located in melanosome. Is expressed in central nervous system; eye; head mesenchyme; mesenchyme derived from neural crest; and skin. Used to study buphthalmos and oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (Tyrosinase). [provided by Alliance of Genome Resources, Apr 2022]

Tyr 基因产物(2)

mRNA Protein Name
NM_001317397.1 NP_001304326.1 tyrosinase isoform 2 precursor
NM_011661.5 NP_035791.1 tyrosinase isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9918801 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9918801 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9918801 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell population proliferation IMP
IMP: 通过突变表型推断
9548375 MGI
acts upstream of or within melanin biosynthetic process IMP
IMP: 通过突变表型推断
7665913 MGI
acts upstream of or within pigmentation IMP
IMP: 通过突变表型推断
9548375 MGI
acts upstream of or within thymus development IMP
IMP: 通过突变表型推断
10890980 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in melanosome IDA
IDA: 通过直接分析推断
9918801 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

tyrosinase

albino locus protein

monophenol monooxygenase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tyr NCBI NCBI:7299
Canis familiaris Tyr NCBI NCBI:403405
Macaca fascicularis Tyr NCBI NCBI:102141480
Susscrofa domestica Tyr NCBI
Leporidae Tyr NCBI
Rattus norvegicus Tyr NCBI NCBI:308800
Macaca mulatta Tyr NCBI NCBI:705792